SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 5 TYR A 218
PRO A  23
LEU A  24
THR A 314
 None
 1.35A 1i2wA-1nt4A:
undetectable		 1i2wA-1nt4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 8 SER A 250
THR A 156
ASP A 157
LEU A 150
 None
 1.06A 1lhvA-1nt4A:
0.0		 1lhvA-1nt4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 ASP A 301
THR A 298
GLU A 149
 None
 0.80A 1pj7A-1nt4A:
undetectable		 1pj7A-1nt4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 4 ALA A  99
VAL A 287
ALA A  89
HIS A 116
 None
 1.11A 1q23F-1nt4A:
0.0		 1q23F-1nt4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 4 ALA A  99
VAL A 287
ALA A  89
HIS A 116
 None
 1.21A 1q23K-1nt4A:
0.0		 1q23K-1nt4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 12 GLY A  61
ALA A 106
ILE A 283
VAL A 114
ILE A 103
 None
 1.13A 1sduB-1nt4A:
undetectable		 1sduB-1nt4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 8 LYS A 271
TYR A 268
TYR A  88
TYR A  86
 None
 1.46A 1xqlA-1nt4A:
undetectable
1xqlB-1nt4A:
undetectable		 1xqlA-1nt4A:
21.33
1xqlB-1nt4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 7 ILE A 293
ARG A  17
TYR A 305
GLU A 312
 None
G1P  A2000 (-4.0A)
None
None
 1.05A 2qebA-1nt4A:
undetectable		 2qebA-1nt4A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 7 ILE A 293
ARG A  17
TYR A 305
GLU A 312
 None
G1P  A2000 (-4.0A)
None
None
 1.08A 2qebB-1nt4A:
undetectable		 2qebB-1nt4A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 TYR A 268
ASP A 124
HIS A 115
 None
 0.68A 3e23A-1nt4A:
undetectable		 3e23A-1nt4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 8 ASP A 327
LEU A 334
ASP A 372
ASP A 374
 None
 1.26A 3n2oC-1nt4A:
undetectable
3n2oD-1nt4A:
undetectable		 3n2oC-1nt4A:
21.61
3n2oD-1nt4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 8 ALA A 142
GLN A 141
ASP A 133
SER A 135
 None
 1.03A 3qj7A-1nt4A:
undetectable
3qj7D-1nt4A:
undetectable		 3qj7A-1nt4A:
23.86
3qj7D-1nt4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 12 LEU A 366
ILE A 337
ILE A 371
ASP A 380
LEU A 273
 None
 1.07A 3uj7B-1nt4A:
undetectable		 3uj7B-1nt4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 PHE A 127
TYR A  86
TYR A 268
 None
 0.97A 4ffwA-1nt4A:
undetectable		 4ffwA-1nt4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 10 LEU A 265
PHE A 322
SER A 295
ILE A 320
THR A 284
 None
 1.27A 4g8zX-1nt4A:
undetectable		 4g8zX-1nt4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 5 GLU A  32
SER A  34
PRO A 172
SER A 171
 None
 1.21A 4k17B-1nt4A:
undetectable		 4k17B-1nt4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.87A 4k8cA-1nt4A:
undetectable		 4k8cA-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.86A 4kahA-1nt4A:
undetectable		 4kahA-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.87A 4kahB-1nt4A:
undetectable		 4kahB-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.85A 4kanA-1nt4A:
undetectable		 4kanA-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.86A 4kanB-1nt4A:
undetectable		 4kanB-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.87A 4kbeA-1nt4A:
undetectable		 4kbeA-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.88A 4kbeB-1nt4A:
undetectable		 4kbeB-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.87A 4lbgA-1nt4A:
undetectable		 4lbgA-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 SER A 208
TYR A 247
PRO A  23
 None
 0.86A 4lbgB-1nt4A:
undetectable		 4lbgB-1nt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 7 TYR A 247
LEU A  20
THR A  50
THR A 314
 None
 1.01A 4mbsA-1nt4A:
undetectable		 4mbsA-1nt4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 12 GLY A  61
ALA A 106
LEU A  68
PHE A 102
SER A  16
 None
 1.33A 4pb1A-1nt4A:
undetectable		 4pb1A-1nt4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 12 MET A 379
MET A 335
PHE A 322
LEU A 296
THR A 126
 None
 1.28A 4zjlA-1nt4A:
2.3		 4zjlA-1nt4A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		3 / 3 ILE A 112
PRO A 113
ILE A 103
 None
 0.39A 5hw8F-1nt4A:
undetectable		 5hw8F-1nt4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 12 ALA A 272
LEU A 386
ILE A 320
LEU A 300
LEU A 286
 None
 0.92A 5toaA-1nt4A:
undetectable		 5toaA-1nt4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		5 / 7 SER A  16
GLY A  61
ALA A 106
VAL A  74
LEU A  68
 None
 1.09A 6dwnB-1nt4A:
0.0		 6dwnB-1nt4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1nt4 GLUCOSE-1-PHOSPHATAS
E
(Escherichia
coli) 		4 / 6 ILE A 293
LEU A 296
TYR A 305
THR A 363
 None
 1.10A 6nmfN-1nt4A:
undetectable
6nmfW-1nt4A:
undetectable		 6nmfN-1nt4A:
21.40
6nmfW-1nt4A:
12.37