SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ntg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 SER A 140
GLU A 141
GLU A 142
 None
 0.62A 1eqbD-1ntgA:
undetectable		 1eqbD-1ntgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 SER A 140
GLU A 141
GLU A 142
 None
 0.62A 1eqbB-1ntgA:
undetectable		 1eqbB-1ntgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ILE A 139
GLY A 166
GLY A 167
CYH A 143
LEU A  97
 None
 1.00A 1liiA-1ntgA:
undetectable		 1liiA-1ntgA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 GLN A  50
VAL A  49
LEU A  48
SER A  46
LEU A  29
 None
 0.97A 2c12C-1ntgA:
undetectable		 2c12C-1ntgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 GLN A  50
VAL A  49
LEU A  48
SER A  46
LEU A  29
 None
 0.97A 2c12F-1ntgA:
0.0		 2c12F-1ntgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ILE A  12
PHE A 130
LEU A  97
PHE A 137
ILE A 169
 None
 1.12A 2y7kD-1ntgA:
undetectable		 2y7kD-1ntgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 GLY A 106
ASP A  35
ILE A  34
VAL A  64
 None
 0.81A 3fi0E-1ntgA:
undetectable		 3fi0E-1ntgA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 GLY A 106
ASP A  35
ILE A  34
VAL A  64
 None
 0.79A 3fi0G-1ntgA:
undetectable		 3fi0G-1ntgA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 PHE A 152
TYR A 114
LEU A 156
 None
 0.79A 3sueB-1ntgA:
undetectable		 3sueB-1ntgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 5 GLY A 166
GLY A 167
ASN A 168
GLU A 141
 None
 1.17A 4fglC-1ntgA:
undetectable		 4fglC-1ntgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 THR A  19
PRO A 105
ARG A  13
 None
 0.77A 5nd7B-1ntgA:
undetectable		 5nd7B-1ntgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ntg TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 9 VAL A  62
VAL A  20
GLY A  47
LEU A  48
VAL A  44
 None
 1.12A 6czmA-1ntgA:
undetectable
6czmB-1ntgA:
undetectable		 6czmA-1ntgA:
17.75
6czmB-1ntgA:
17.75