SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 5 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.97A 1wrkB-1ntyA:
undetectable		 1wrkB-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 7 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.95A 1wrlA-1ntyA:
undetectable
1wrlB-1ntyA:
undetectable		 1wrlA-1ntyA:
17.19
1wrlB-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 6 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.97A 1wrlB-1ntyA:
undetectable		 1wrlB-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 5 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.97A 1wrlC-1ntyA:
undetectable		 1wrlC-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 8 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.96A 1wrlC-1ntyA:
undetectable
1wrlD-1ntyA:
undetectable		 1wrlC-1ntyA:
17.19
1wrlD-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 7 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 0.98A 1wrlE-1ntyA:
undetectable		 1wrlE-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 7 PHE A1296
LEU A1241
PHE A1321
MET A1398
 None
 1.00A 1wrlE-1ntyA:
undetectable
1wrlF-1ntyA:
undetectable		 1wrlE-1ntyA:
17.19
1wrlF-1ntyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 5 LEU A1498
LEU A1450
LEU A1429
LEU A1512
 None
 1.06A 1yajD-1ntyA:
undetectable		 1yajD-1ntyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 10 PHE A1291
GLU A1245
VAL A1310
TYR A1373
PHE A1314
 None
 1.24A 3r6wA-1ntyA:
0.0
3r6wB-1ntyA:
undetectable		 3r6wA-1ntyA:
19.63
3r6wB-1ntyA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1414
 None
 1.14A 4coxC-1ntyA:
undetectable		 4coxC-1ntyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 6 LEU A1252
PRO A1366
GLU A1245
TYR A1248
 None
 1.24A 4z4gA-1ntyA:
undetectable		 4z4gA-1ntyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 6 TYR A1303
HIS A1312
GLY A1311
GLU A1390
 None
 1.27A 4zbqA-1ntyA:
undetectable		 4zbqA-1ntyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1411
 None
 1.22A 5iktB-1ntyA:
undetectable		 5iktB-1ntyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1414
 None
 1.23A 5iktB-1ntyA:
undetectable		 5iktB-1ntyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens) 		3 / 3 ILE A1527
ASN A1519
CYH A1494
 None
 0.83A 6bp4A-1ntyA:
0.0		 6bp4A-1ntyA:
20.99