SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 5 SER A 301
THR A 302
GLU A  46
GLY A  45
 None
 1.33A 1icrA-1nu5A:
undetectable
1icrB-1nu5A:
undetectable		 1icrA-1nu5A:
20.75
1icrB-1nu5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 5 GLU A  46
GLY A  45
SER A 301
THR A 302
 None
 1.34A 1icrA-1nu5A:
0.0
1icrB-1nu5A:
0.0		 1icrA-1nu5A:
20.75
1icrB-1nu5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 5 SER A 301
THR A 302
GLU A  46
GLY A  45
 None
 1.31A 1icvC-1nu5A:
undetectable
1icvD-1nu5A:
undetectable		 1icvC-1nu5A:
20.75
1icvD-1nu5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 11 LEU A 270
LEU A 268
ALA A 258
ALA A 286
LEU A 280
 None
 1.24A 1iiuA-1nu5A:
undetectable		 1iiuA-1nu5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 11 LEU A 270
LEU A 268
ALA A 289
ALA A 286
LEU A 280
 None
 1.29A 1iiuA-1nu5A:
undetectable		 1iiuA-1nu5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 12 LEU A 270
LEU A 268
ALA A 258
ALA A 286
LEU A 280
 None
 1.36A 1kt5A-1nu5A:
0.0		 1kt5A-1nu5A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 12 LEU A 270
LEU A 268
ALA A 289
ALA A 286
LEU A 280
 None
 1.35A 1kt5A-1nu5A:
0.0		 1kt5A-1nu5A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 7 LEU A 315
GLY A 290
ILE A 291
PRO A 319
 None
 0.73A 2aojB-1nu5A:
undetectable		 2aojB-1nu5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 8 GLY A  45
GLY A 304
THR A 305
ALA A 306
ALA A 307
 None
 1.13A 2ej3A-1nu5A:
undetectable		 2ej3A-1nu5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 10 GLY A  45
GLY A 304
THR A 305
ALA A 306
ALA A 307
 None
 1.16A 2ej3B-1nu5A:
undetectable		 2ej3B-1nu5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 8 GLY A  45
GLY A 304
THR A 305
ALA A 306
ALA A 307
 None
 1.14A 2ej3C-1nu5A:
undetectable		 2ej3C-1nu5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 12 LEU A 315
GLY A 290
ILE A 291
PRO A 319
LEU A 318
 None
 0.93A 2o4nA-1nu5A:
undetectable		 2o4nA-1nu5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 9 ALA A  38
GLY A  77
LEU A 111
ILE A 104
ALA A  80
 None
 0.91A 2z0yB-1nu5A:
2.4		 2z0yB-1nu5A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 7 VAL A 356
HIS A 310
LEU A 348
TRP A 328
 None
 1.19A 3arrA-1nu5A:
5.6		 3arrA-1nu5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 7 LYS A 269
LEU A 248
ASP A 245
SER A 253
 MN  A 371 ( 4.2A)
None
MN  A 371 (-3.2A)
None
 1.46A 3dzgA-1nu5A:
2.6		 3dzgA-1nu5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 5 ILE A  33
THR A   9
THR A   8
SER A   7
 None
 1.12A 3snfA-1nu5A:
undetectable		 3snfA-1nu5A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 9 LEU A 315
GLY A 290
ILE A 291
PRO A 319
LEU A 318
 None
 0.95A 3u7sA-1nu5A:
undetectable		 3u7sA-1nu5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 8 THR A  62
GLY A  48
GLY A  47
VAL A  32
 None
 0.68A 4qvvK-1nu5A:
undetectable
4qvvL-1nu5A:
undetectable		 4qvvK-1nu5A:
23.48
4qvvL-1nu5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 8 THR A  62
GLY A  48
GLY A  47
VAL A  32
 None
 0.68A 4qvvY-1nu5A:
undetectable
4qvvZ-1nu5A:
undetectable		 4qvvY-1nu5A:
23.48
4qvvZ-1nu5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 8 ALA A 100
ALA A 103
ILE A 104
ALA A 277
LEU A 108
 None
 1.30A 4v1fA-1nu5A:
undetectable
4v1fB-1nu5A:
undetectable		 4v1fA-1nu5A:
14.79
4v1fB-1nu5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 7 SER A 119
GLY A 126
GLY A 125
ALA A 121
 None
 0.74A 4yjiA-1nu5A:
undetectable		 4yjiA-1nu5A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 12 LEU A 175
GLN A 173
VAL A 164
VAL A 193
VAL A 216
 None
 1.12A 5dpdA-1nu5A:
undetectable		 5dpdA-1nu5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		4 / 7 LEU A 309
THR A 305
ILE A 325
LEU A 299
 None
 0.95A 5fxtA-1nu5A:
undetectable		 5fxtA-1nu5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 12 VAL A 193
LEU A 166
ALA A 150
GLY A 215
LEU A 211
 None
 0.88A 5jw1A-1nu5A:
1.0		 5jw1A-1nu5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 12 GLU A  58
GLY A 274
ASN A 272
LEU A 248
ALA A 254
 None
 1.33A 5kbwA-1nu5A:
0.3		 5kbwA-1nu5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1nu5 CHLOROMUCONATE
CYCLOISOMERASE
(Pseudomonas
sp.
P51) 		5 / 11 VAL A 356
GLY A 355
SER A 119
ALA A 306
LEU A 339
 None
 1.20A 5x6yC-1nu5A:
undetectable		 5x6yC-1nu5A:
20.52