SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 8 ILE A 660
LEU A 636
ALA A 604
VAL A 610
 None
 0.78A 1a29A-1nugA:
undetectable		 1a29A-1nugA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 12 LEU A 185
PHE A 134
GLY A 287
GLY A 216
LEU A 219
 CL  A 701 (-4.3A)
None
None
None
None
 0.99A 1fe2A-1nugA:
0.0		 1fe2A-1nugA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		3 / 3 ARG A 247
THR A 294
VAL A 164
 None
 1.00A 1hxbA-1nugA:
0.0		 1hxbA-1nugA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 12 LEU A 185
PHE A 134
GLY A 287
GLY A 216
LEU A 219
 CL  A 701 (-4.3A)
None
None
None
None
 1.05A 1igxA-1nugA:
1.0		 1igxA-1nugA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		3 / 3 ASP A 434
LYS A 438
ARG A 375
 None
 1.15A 1ra8A-1nugA:
undetectable		 1ra8A-1nugA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 11 GLY A 277
ALA A 276
GLY A 270
PHE A 329
VAL A 331
 None
 0.83A 2fxdA-1nugA:
undetectable		 2fxdA-1nugA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 8 THR A 667
GLN A 669
ASP A 689
SER A 687
 None
 0.94A 2xz5A-1nugA:
3.4
2xz5C-1nugA:
3.4		 2xz5A-1nugA:
18.10
2xz5C-1nugA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 8 THR A 667
GLN A 669
ASP A 689
SER A 687
 None
 0.94A 2xz5C-1nugA:
3.4
2xz5D-1nugA:
3.5		 2xz5C-1nugA:
18.10
2xz5D-1nugA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 11 ILE A 660
LEU A 686
ALA A 684
VAL A 631
ILE A 643
 None
 1.15A 3b2rB-1nugA:
undetectable		 3b2rB-1nugA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 12 GLY A 270
VAL A 267
ALA A 276
THR A 278
LEU A 256
 None
 1.08A 3dh0B-1nugA:
undetectable		 3dh0B-1nugA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 LYS A 505
SER A 541
LEU A 507
SER A 481
 None
 1.19A 3ijxH-1nugA:
undetectable		 3ijxH-1nugA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 4 LYS A 505
SER A 541
LEU A 507
SER A 481
 None
 1.23A 3ik6H-1nugA:
0.0		 3ik6H-1nugA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 LYS A 505
SER A 541
LEU A 507
SER A 481
 None
 1.24A 3iluH-1nugA:
undetectable		 3iluH-1nugA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		3 / 3 LEU A 256
TRP A 259
GLY A 230
 None
None
CA  A 703 ( 4.4A)
 0.58A 3l35A-1nugA:
undetectable
3l35H-1nugA:
undetectable		 3l35A-1nugA:
4.95
3l35H-1nugA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		3 / 3 LEU A 256
TRP A 259
GLY A 230
 None
None
CA  A 703 ( 4.4A)
 0.51A 3l35B-1nugA:
undetectable
3l35K-1nugA:
undetectable		 3l35B-1nugA:
4.95
3l35K-1nugA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 11 ARG A 244
ASN A 224
VAL A 231
ILE A 223
GLY A 277
 None
CA  A 703 (-3.0A)
None
None
None
 1.03A 3lzvB-1nugA:
undetectable		 3lzvB-1nugA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		3 / 3 ASP A 245
ARG A 247
ALA A 681
 None
 0.76A 3mbgC-1nugA:
0.0		 3mbgC-1nugA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 6 LEU A 352
SER A 220
ALA A 221
ARG A 217
 None
None
CA  A 703 (-4.5A)
None
 1.03A 3ravA-1nugA:
undetectable		 3ravA-1nugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 6 LEU A 352
SER A 220
ALA A 221
LEU A 283
 None
None
CA  A 703 (-4.5A)
None
 1.00A 3ravA-1nugA:
undetectable		 3ravA-1nugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 6 LEU A 352
SER A 220
ALA A 221
ARG A 217
 None
None
CA  A 703 (-4.5A)
None
 1.05A 3rd0A-1nugA:
undetectable		 3rd0A-1nugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 12 PHE A 452
VAL A 413
ILE A 397
ILE A 418
GLU A 443
 None
None
None
None
CA  A 704 (-2.5A)
 1.45A 4a99A-1nugA:
undetectable
4a99C-1nugA:
undetectable		 4a99A-1nugA:
21.66
4a99C-1nugA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 HIS A 330
SER A 298
GLN A 357
VAL A 326
 None
 1.16A 4a99D-1nugA:
undetectable		 4a99D-1nugA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 11 PHE A  24
CYH A 188
LEU A 286
ILE A 288
ILE A 131
 None
 1.20A 4dm8A-1nugA:
undetectable		 4dm8A-1nugA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 7 SER A 195
ALA A 221
SER A 220
ARG A 217
 None
CA  A 703 (-4.5A)
None
None
 1.22A 4lv9A-1nugA:
undetectable
4lv9B-1nugA:
undetectable		 4lv9A-1nugA:
21.64
4lv9B-1nugA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 SER A 220
ARG A 217
LEU A 352
ASP A 353
 None
 1.43A 4xdtA-1nugA:
0.0		 4xdtA-1nugA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		5 / 10 TYR A 312
PRO A 318
ILE A 523
THR A 572
ILE A 571
 None
 1.28A 5mvnD-1nugA:
4.1		 5mvnD-1nugA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 8 ARG A 284
ILE A 107
LEU A 219
GLY A 216
 None
 0.86A 5nooD-1nugA:
undetectable		 5nooD-1nugA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 ARG A 653
MET A 614
THR A 597
LEU A 596
 None
 1.41A 5x1bW-1nugA:
0.0		 5x1bW-1nugA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 6 PHE A 275
GLY A 277
THR A 278
ASN A 280
 None
 0.74A 5x24A-1nugA:
0.0		 5x24A-1nugA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 GLY A 230
ASN A 229
ASP A 228
ARG A 199
 CA  A 703 ( 4.4A)
None
CA  A 703 (-2.3A)
None
 1.33A 6dwdB-1nugA:
undetectable
6dwdD-1nugA:
undetectable		 6dwdB-1nugA:
21.10
6dwdD-1nugA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 THR A 398
ARG A 396
THR A 519
ASP A 536
 None
 1.25A 6ecxA-1nugA:
undetectable		 6ecxA-1nugA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens) 		4 / 5 ARG A 653
MET A 614
THR A 597
LEU A 596
 None
 1.42A 6nknJ-1nugA:
0.0		 6nknJ-1nugA:
7.54