SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 8 GLU A 127
ALA A 163
ALA A 119
THR A 114
 None
 0.92A 1ie4B-1nvmA:
undetectable
1ie4D-1nvmA:
undetectable		 1ie4B-1nvmA:
17.57
1ie4D-1nvmA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 8 VAL B 231
VAL B 211
ASP B 209
VAL B 273
 None
 0.71A 1iwiA-1nvmB:
undetectable		 1iwiA-1nvmB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 SER A  20
SER A 226
ALA A  38
ASP A  31
ILE A 267
 None
 1.16A 1nt2A-1nvmA:
undetectable		 1nt2A-1nvmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		3 / 3 VAL B 147
ALA B 148
HIS B 151
 None
 0.73A 1q23H-1nvmB:
undetectable		 1q23H-1nvmB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 9 PHE B  76
GLU B  88
ASN B  87
ILE B  10
ALA B   8
 None
None
NAD  B3501 ( 4.3A)
NAD  B3501 (-4.9A)
None
 1.38A 2drdA-1nvmB:
2.8		 2drdA-1nvmB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.98A 2f81A-1nvmB:
undetectable		 2f81A-1nvmB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 SER B 163
ILE B 159
SER B 160
ASN B 290
VAL A 322
 NAD  B3501 (-4.8A)
None
None
NAD  B3501 (-3.6A)
None
 0.93A 2nnhA-1nvmB:
0.0		 2nnhA-1nvmB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 165
LEU B  19
GLY B  16
GLY B  13
LEU B 103
 NAD  B3501 (-3.6A)
None
None
NAD  B3501 (-3.4A)
None
 0.89A 2nxeA-1nvmB:
6.8		 2nxeA-1nvmB:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 GLY A 233
GLY A 235
ASN A 204
ALA A 237
GLY A 172
 None
 1.00A 2pkkA-1nvmA:
2.6		 2pkkA-1nvmA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.18A 2pxcA-1nvmB:
3.1		 2pxcA-1nvmB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		3 / 3 ARG A 222
SER A  46
TYR A 167
 None
 0.81A 2q2hA-1nvmA:
0.0
2q2hB-1nvmA:
0.0		 2q2hA-1nvmA:
18.01
2q2hB-1nvmA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 7 SER A 171
HIS A  21
HIS A 202
TYR A 291
 OXL  A3508 (-2.4A)
None
MN  A3504 ( 3.4A)
OXL  A3508 (-4.6A)
 1.46A 2vmyA-1nvmA:
2.3
2vmyB-1nvmA:
2.4		 2vmyA-1nvmA:
23.42
2vmyB-1nvmA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 LEU B 263
GLY A  65
GLN A  26
PHE B 266
LEU B 214
 None
None
SO4  A3513 ( 3.8A)
None
None
 1.37A 2w8yA-1nvmB:
undetectable		 2w8yA-1nvmB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 ASP A  18
PHE A 294
TYR A 291
ASP A  53
HIS A 297
 MN  A3504 ( 2.7A)
None
OXL  A3508 (-4.6A)
None
None
 1.39A 2x2iA-1nvmA:
5.3		 2x2iA-1nvmA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 ASP A  53
LEU A  90
ASN A 236
ASP A  18
PHE A 139
 None
None
MN  A3504 ( 4.2A)
MN  A3504 ( 2.7A)
OXL  A3508 (-4.7A)
 1.42A 2x2iA-1nvmA:
5.3		 2x2iA-1nvmA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 ASP A  53
LEU A  90
ASN A 236
ASP A  18
PHE A 139
 None
None
MN  A3504 ( 4.2A)
MN  A3504 ( 2.7A)
OXL  A3508 (-4.7A)
 1.36A 2x2iB-1nvmA:
6.7		 2x2iB-1nvmA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		3 / 3 MET A 199
VAL A  44
GLU A  48
 None
 0.77A 2x9gA-1nvmA:
undetectable		 2x9gA-1nvmA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		3 / 3 ARG B 169
GLY B 167
SER B  42
 None
NAD  B3501 (-3.5A)
NAD  B3501 ( 4.0A)
 0.66A 2xctB-1nvmB:
3.6		 2xctB-1nvmB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 7 VAL B 211
ILE B 155
ALA B 153
VAL B 213
THR B 137
 None
 1.24A 2xrzB-1nvmB:
1.7		 2xrzB-1nvmB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 7 THR B  79
ILE B  10
GLY B  11
ILE B  38
 NAD  B3501 (-4.1A)
NAD  B3501 (-4.9A)
NAD  B3501 (-3.2A)
NAD  B3501 (-4.2A)
 0.70A 2y7wC-1nvmB:
1.6		 2y7wC-1nvmB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 6 TYR A 128
ALA A 129
LEU A 132
ALA A 102
 None
 0.87A 3b6hB-1nvmA:
undetectable		 3b6hB-1nvmA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 ILE B  10
GLY B  11
ILE B  38
ASP B  39
GLY B  59
THR B  79
 NAD  B3501 (-4.9A)
NAD  B3501 (-3.2A)
NAD  B3501 (-4.2A)
None
NAD  B3501 ( 3.9A)
NAD  B3501 (-4.1A)
 1.14A 3bwcA-1nvmB:
4.8		 3bwcA-1nvmB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.94A 3cywA-1nvmB:
undetectable		 3cywA-1nvmB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.89A 3d1zA-1nvmB:
undetectable		 3d1zA-1nvmB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.99A 3d20A-1nvmB:
undetectable		 3d20A-1nvmB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 8 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 1.06A 3ekpA-1nvmB:
undetectable		 3ekpA-1nvmB:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 11 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.96A 3ekxA-1nvmB:
undetectable		 3ekxA-1nvmB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 9 VAL B 211
GLY B 187
ILE B 186
ALA B 136
ILE B 155
 None
 1.01A 3el0B-1nvmB:
undetectable		 3el0B-1nvmB:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.32A 3elwA-1nvmB:
3.7		 3elwA-1nvmB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 ILE B  10
GLY B  11
VAL B  36
ILE B  38
ALA B  78
 NAD  B3501 (-4.9A)
NAD  B3501 (-3.2A)
None
NAD  B3501 (-4.2A)
NAD  B3501 (-4.7A)
 0.58A 3fpjA-1nvmB:
5.3		 3fpjA-1nvmB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 7 ILE A  35
TYR A  27
THR A  28
GLY A  19
 None
None
SO4  A3512 (-4.0A)
None
 0.96A 3gssB-1nvmA:
0.0		 3gssB-1nvmA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 6 SER A 226
ARG A 274
GLU A 281
GLU A 299
 None
 0.97A 3k9fA-1nvmA:
undetectable
3k9fB-1nvmA:
undetectable
3k9fD-1nvmA:
undetectable		 3k9fA-1nvmA:
23.36
3k9fB-1nvmA:
23.36
3k9fD-1nvmA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 6 ALA B 107
ILE B 108
HIS B  84
ASN B 126
 None
 1.01A 3nneG-1nvmB:
undetectable		 3nneG-1nvmB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 7 ALA B 148
SER B 215
VAL B 213
VAL B 150
 None
 0.87A 3o14A-1nvmB:
undetectable		 3o14A-1nvmB:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 10 LEU B 275
ASP B 209
ALA B 157
ILE B 197
ILE B 183
 None
 1.22A 3ogpB-1nvmB:
undetectable		 3ogpB-1nvmB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 1.02A 3pwmA-1nvmB:
undetectable		 3pwmA-1nvmB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 8 ALA A  36
ILE A  47
LEU A  16
GLU A  79
ALA A  75
 None
 1.33A 3r9tA-1nvmA:
undetectable		 3r9tA-1nvmA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 GLY A 208
LEU A 205
ASP A  13
VAL A  14
GLY A 235
 None
 0.99A 3sglA-1nvmA:
undetectable		 3sglA-1nvmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 5 ASP A  53
GLY A 323
TYR A  62
GLU A 326
 None
 1.37A 3w9tA-1nvmA:
undetectable		 3w9tA-1nvmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 5 ASP A  53
GLY A 323
TYR A  62
GLU A 326
 None
 1.35A 3w9tC-1nvmA:
undetectable		 3w9tC-1nvmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 5 ASP A  53
GLY A 323
TYR A  62
GLU A 326
 None
 1.35A 3w9tD-1nvmA:
undetectable		 3w9tD-1nvmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 5 ASP A  53
GLY A 323
TYR A  62
GLU A 326
 None
 1.35A 3w9tG-1nvmA:
0.0		 3w9tG-1nvmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 8 HIS A  51
GLY A  57
ALA A  50
GLU A  48
 None
 0.84A 4bjcA-1nvmA:
undetectable		 4bjcA-1nvmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 11 GLY B 240
ALA B 280
GLY B 279
LYS B  22
HIS B 282
 None
 1.28A 4c5lA-1nvmB:
5.5		 4c5lA-1nvmB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 9 ASP A  18
ALA A 232
GLY A 231
VAL A  14
HIS A 202
 MN  A3504 ( 2.7A)
None
None
None
MN  A3504 ( 3.4A)
 1.49A 4c5lB-1nvmA:
undetectable		 4c5lB-1nvmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 10 ASP A  18
ALA A 232
GLY A 231
VAL A  14
HIS A 202
 MN  A3504 ( 2.7A)
None
None
None
MN  A3504 ( 3.4A)
 1.45A 4c5lD-1nvmA:
2.2		 4c5lD-1nvmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 10 ASP A  18
ALA A 232
GLY A 231
VAL A  14
HIS A 202
 MN  A3504 ( 2.7A)
None
None
None
MN  A3504 ( 3.4A)
 1.45A 4c5nD-1nvmA:
2.3		 4c5nD-1nvmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 8 GLU B 154
GLU B 177
GLY A  94
SER A  95
 None
 1.02A 4f93B-1nvmB:
2.9		 4f93B-1nvmB:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 6 GLY A 324
GLY A 323
MET A 141
ILE A  93
 None
None
OXL  A3508 (-3.6A)
None
 0.99A 4fglD-1nvmA:
undetectable		 4fglD-1nvmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 7 GLY A 172
ALA A 232
SER A 292
TYR A 291
 None
None
None
OXL  A3508 (-4.6A)
 0.91A 4hyfA-1nvmA:
undetectable		 4hyfA-1nvmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 8 GLY A 172
ALA A 232
SER A 292
TYR A 291
 None
None
None
OXL  A3508 (-4.6A)
 0.92A 4hyfB-1nvmA:
undetectable		 4hyfB-1nvmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 8 GLY A 172
ALA A 232
SER A 292
TYR A 291
 None
None
None
OXL  A3508 (-4.6A)
 0.90A 4hyfC-1nvmA:
undetectable		 4hyfC-1nvmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 LEU B  91
ALA B   8
PHE B  76
LEU B 103
ILE B  10
 None
None
None
None
NAD  B3501 (-4.9A)
 1.21A 4hytC-1nvmB:
undetectable		 4hytC-1nvmB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 11 GLY A 229
ALA A 228
ASP A 265
ILE A 243
VAL A 268
 None
 1.02A 4l1aA-1nvmA:
undetectable		 4l1aA-1nvmA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.98A 4njvA-1nvmB:
undetectable		 4njvA-1nvmB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 11 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 1.00A 4njvC-1nvmB:
undetectable		 4njvC-1nvmB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 5 ILE A 329
ARG A  24
GLU A 326
VAL B 156
 None
SO4  A3513 (-3.7A)
None
None
 1.27A 4nkxD-1nvmA:
0.0		 4nkxD-1nvmA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 9 ALA A 246
ALA A 244
LEU A 260
SER A 212
VAL A 209
 None
 1.29A 4or0A-1nvmA:
undetectable		 4or0A-1nvmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 10 GLY A  54
ASP A  18
ALA A 169
LEU A  88
LEU A  90
 None
MN  A3504 ( 2.7A)
OXL  A3508 ( 4.0A)
None
None
 1.15A 4xj7A-1nvmA:
undetectable
4xj7B-1nvmA:
undetectable		 4xj7A-1nvmA:
22.61
4xj7B-1nvmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		3 / 3 LEU A 140
VAL A 121
ASP A 120
 None
 0.55A 4y8wC-1nvmA:
undetectable		 4y8wC-1nvmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		3 / 3 VAL A  32
TYR A  72
ALA A  75
 None
 0.56A 4ybnA-1nvmA:
0.0		 4ybnA-1nvmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 GLY A 231
MET A 230
LEU A  90
GLY A 138
HIS A 202
 None
None
None
None
MN  A3504 ( 3.4A)
 1.11A 4ze1A-1nvmA:
0.0		 4ze1A-1nvmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 7 VAL B 147
LEU B 269
VAL B 247
THR B 271
 None
 0.99A 5e4dA-1nvmB:
undetectable
5e4dB-1nvmB:
undetectable		 5e4dA-1nvmB:
19.56
5e4dB-1nvmB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.19A 5ikmA-1nvmB:
3.3		 5ikmA-1nvmB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		4 / 7 VAL B  60
GLU B  61
ASN B 126
ILE B 108
 None
MPD  B3528 (-3.4A)
None
None
 1.03A 5jh7C-1nvmB:
2.9		 5jh7C-1nvmB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		5 / 12 GLY A 229
HIS A 203
PHE A 242
VAL A 241
ILE A  47
 None
 1.12A 5n0xA-1nvmA:
undetectable		 5n0xA-1nvmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 8 THR A  15
GLN A 272
ILE A  23
GLY A  19
 None
 0.95A 5nzxA-1nvmA:
0.0		 5nzxA-1nvmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		4 / 7 THR A  15
GLN A 272
ILE A  23
GLY A  19
 None
 0.89A 5nzyA-1nvmA:
0.0		 5nzyA-1nvmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.16A 5wz1B-1nvmB:
3.5		 5wz1B-1nvmB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.16A 5wz2A-1nvmB:
3.1		 5wz2A-1nvmB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.13A 5wz2B-1nvmB:
3.2		 5wz2B-1nvmB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		6 / 12 GLY B 167
GLY B  16
GLY B  13
GLY B 165
THR B  17
ILE B   9
 NAD  B3501 (-3.5A)
None
NAD  B3501 (-3.4A)
NAD  B3501 (-3.6A)
None
None
 1.16A 5wz2C-1nvmB:
3.0		 5wz2C-1nvmB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		3 / 3 MET A 184
ASP A 221
ARG A 111
 None
 1.20A 5z6kA-1nvmA:
0.0		 5z6kA-1nvmA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)
(Pseudomonas
sp.
CF600) 		5 / 12 GLY B 192
VAL B 211
GLY B 187
ILE B 186
ILE B 155
 None
 0.96A 6dh3B-1nvmB:
undetectable		 6dh3B-1nvmB:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE
(Pseudomonas
sp.
CF600) 		3 / 3 TRP A 251
ILE A 213
GLU A 218
 None
 0.70A 6hcxA-1nvmA:
undetectable		 6hcxA-1nvmA:
12.46