SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 MET C 358
LEU C 360
ARG D  82
GLY C 372
 None
 0.92A 2po5B-1nvpC:
undetectable		 2po5B-1nvpC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 1nvp TATA BOX BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 321
CYH A 262
ILE A 304
ILE A 328
 None
 0.85A 2q83A-1nvpA:
undetectable		 2q83A-1nvpA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
(Homo
sapiens) 		4 / 6 MET C 358
LYS C 369
PHE C 367
ILE C 366
 None
 1.41A 2w98B-1nvpC:
undetectable		 2w98B-1nvpC:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens) 		5 / 12 ASN C 359
ILE D  44
ALA D  43
VAL D  36
LEU D  15
 None
 1.20A 3a51E-1nvpC:
undetectable		 3a51E-1nvpC:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C 342
ARG D  66
THR D  64
LEU D  62
 None
 1.00A 3ag1N-1nvpC:
undetectable
3ag1W-1nvpC:
undetectable		 3ag1N-1nvpC:
9.31
3ag1W-1nvpC:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens) 		4 / 4 ILE D  44
GLN D   4
ILE C 357
LEU D  34
 None
 1.22A 3dzyD-1nvpD:
undetectable		 3dzyD-1nvpD:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1nvp TATA BOX BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 THR A 210
VAL A 220
THR A 222
VAL A 169
 None
 0.50A 3em0B-1nvpA:
undetectable		 3em0B-1nvpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA ALPHA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LEU B  42
TRP B  46
GLY D  12
 None
 0.78A 3l35A-1nvpB:
undetectable
3l35H-1nvpB:
undetectable		 3l35A-1nvpB:
21.31
3l35H-1nvpB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA ALPHA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LEU B  42
TRP B  46
GLY D  12
 None
 0.73A 3l35B-1nvpB:
undetectable
3l35K-1nvpB:
undetectable		 3l35B-1nvpB:
21.31
3l35K-1nvpB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1nvp TATA BOX BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 VAL A 172
ILE A 168
ALA A 211
ALA A 224
THR A 209
 None
 1.12A 3mdtB-1nvpA:
undetectable		 3mdtB-1nvpA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA ALPHA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens) 		5 / 11 ASP C 364
ALA D  47
TYR B  14
GLY C 356
VAL D  52
 None
 1.08A 4xnxA-1nvpC:
undetectable		 4xnxA-1nvpC:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1nvp TATA BOX BINDING
PROTEIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP D  78
ARG A 188
ARG A 205
 None
 0.79A 5eajB-1nvpD:
undetectable		 5eajB-1nvpD:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens) 		5 / 11 ALA D  97
GLY C 356
ILE C 357
VAL D  93
ILE D  95
 None
 1.26A 5kr2B-1nvpD:
undetectable		 5kr2B-1nvpD:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens) 		4 / 6 ILE D  44
ALA D  47
LEU D  48
ILE C 366
 None
 0.84A 5mvmB-1nvpD:
undetectable
5mvmC-1nvpD:
undetectable		 5mvmB-1nvpD:
25.23
5mvmC-1nvpD:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA D  97
GLY C 356
ILE C 357
VAL D  93
ILE D  95
 None
 1.18A 6difA-1nvpD:
undetectable		 6difA-1nvpD:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN
(Homo
sapiens) 		4 / 6 SER C 368
GLY C 356
ILE D  95
PHE D  74
 None
 0.85A 6f8cA-1nvpC:
undetectable		 6f8cA-1nvpC:
16.25