SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ARG A 141
ALA A 136
ALA A 165
GLU A 169
 None
NAP  A 288 (-4.2A)
None
None
 1.21A 1e7bB-1nvtA:
0.0		 1e7bB-1nvtA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 154
VAL A 189
ASP A 190
ALA A 242
GLY A 193
 None
 0.86A 1kiaB-1nvtA:
6.6		 1kiaB-1nvtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 154
VAL A 189
ASP A 190
ALA A 242
GLY A 193
 None
 0.86A 1kiaC-1nvtA:
6.3		 1kiaC-1nvtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 154
VAL A 189
ASP A 190
ALA A 242
GLY A 193
 None
 0.97A 1nbiB-1nvtA:
5.9		 1nbiB-1nvtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 226
THR A 249
GLU A 235
LEU A 238
 None
 1.05A 1s8fB-1nvtA:
0.9		 1s8fB-1nvtA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A  27
ILE A  17
GLY A  15
TYR A  43
 None
 1.10A 2jkjD-1nvtA:
0.0		 2jkjD-1nvtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A  27
ILE A  17
GLY A  15
TYR A  43
 None
 1.10A 2jkjF-1nvtA:
0.0		 2jkjF-1nvtA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  18
VAL A  48
LEU A  53
PRO A  50
 None
 1.10A 3bgdB-1nvtA:
5.4		 3bgdB-1nvtA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  98
LYS A  61
ILE A  65
TYR A  43
 None
 1.06A 3eteD-1nvtA:
9.2
3eteF-1nvtA:
4.7		 3eteD-1nvtA:
21.56
3eteF-1nvtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.92A 3ln1A-1nvtA:
undetectable		 3ln1A-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.92A 3ln1B-1nvtA:
undetectable		 3ln1B-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.93A 3ln1C-1nvtA:
undetectable		 3ln1C-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.93A 3ln1D-1nvtA:
undetectable		 3ln1D-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A  14
PRO A 272
GLY A 260
VAL A  95
 None
 0.88A 3n3iA-1nvtA:
undetectable		 3n3iA-1nvtA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.96A 3nt1A-1nvtA:
undetectable		 3nt1A-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.95A 3nt1B-1nvtA:
undetectable		 3nt1B-1nvtA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 229
ARG A 116
ASN A 109
 NAP  A 288 (-4.4A)
None
None
 0.75A 3qxvD-1nvtA:
undetectable		 3qxvD-1nvtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 191
VAL A 132
VAL A 215
LEU A 147
 None
 0.73A 3rgfA-1nvtA:
undetectable		 3rgfA-1nvtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.98A 3rr3A-1nvtA:
undetectable		 3rr3A-1nvtA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.99A 3rr3B-1nvtA:
undetectable		 3rr3B-1nvtA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A 111
VAL A 143
GLY A 114
ALA A 115
ALA A 118
 None
 1.15A 3ucjA-1nvtA:
undetectable		 3ucjA-1nvtA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A 111
VAL A 143
GLY A 114
ALA A 115
ALA A 118
 None
 1.16A 3ucjB-1nvtA:
undetectable		 3ucjB-1nvtA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 129
ILE A 131
ILE A 198
 None
 0.59A 4y0qA-1nvtA:
undetectable		 4y0qA-1nvtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.99A 5ikrB-1nvtA:
undetectable		 5ikrB-1nvtA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.92A 5jvzA-1nvtA:
undetectable		 5jvzA-1nvtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 226
TYR A 134
LEU A 238
VAL A 194
LEU A 220
 None
 0.90A 5jw1A-1nvtA:
undetectable		 5jw1A-1nvtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 144
VAL A 143
ILE A 196
VAL A 126
ALA A 148
 None
 1.15A 5nukA-1nvtA:
0.0		 5nukA-1nvtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  16
THR A 110
ASN A 109
 None
 0.49A 6baaE-1nvtA:
undetectable		 6baaE-1nvtA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  16
THR A 110
ASN A 109
 None
 0.49A 6baaF-1nvtA:
undetectable		 6baaF-1nvtA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  16
THR A 110
ASN A 109
 None
 0.50A 6baaG-1nvtA:
undetectable		 6baaG-1nvtA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1nvt SHIKIMATE
5'-DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  16
THR A 110
ASN A 109
 None
 0.50A 6baaH-1nvtA:
undetectable		 6baaH-1nvtA:
11.50