SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_1 (FTSJ)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	ASP A 271 ASP A 46 ASP A 65	SAM A 401 (-2.9A) SAM A 401 (-3.6A) SAM A 401 (-3.3A)	0.54A	1eizA-1nw5A: 2.8	1eizA-1nw5A: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_1 (FTSJ)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	ASP A 271 ASP A 46 ASP A 65	SAM A 401 (-2.9A) SAM A 401 (-3.6A) SAM A 401 (-3.3A)	0.59A	1ej0A-1nw5A: 3.1	1ej0A-1nw5A: 21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1G60_A_SAMA500_0 (ADENINE-SPECIFIC METHYLTRANSFERASE MBOIIA)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	CYH A 47 ASP A 65 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-3.8A) SAM A 401 (-3.3A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	0.26A	1g60A-1nw5A: 25.2	1g60A-1nw5A: 32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	12 / 12	ASP A 46 CYH A 47 PRO A 67 TRP A 84 THR A 225 LYS A 227 PHE A 250 GLY A 252 SER A 253 VAL A 255 ALA A 272 ALA A 273	SAM A 401 (-3.6A) SAM A 401 (-3.8A) SAM A 401 (-4.3A) None SAM A 401 (-3.6A) SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A) SAM A 401 (-4.8A) SAM A 401 (-3.5A) SAM A 401 ( 3.7A)	0.02A	1nw5A-1nw5A: 46.9	1nw5A-1nw5A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	CYH A 47 PRO A 66 THR A 225 LYS A 227 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-3.8A) None SAM A 401 (-3.6A) SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	1.48A	1nw5A-1nw5A: 46.9	1nw5A-1nw5A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1NW5_A_SAMA401_1 (MODIFICATION METHYLASE RSRI)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	ASP A 65 HIS A 223 ASP A 271	SAM A 401 (-3.3A) SAM A 401 (-4.0A) SAM A 401 (-2.9A)	0.01A	1nw5A-1nw5A: 46.9	1nw5A-1nw5A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DPM_A_SAMA300_0 (PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	LYS A 227 PHE A 250 GLY A 252 ASP A 46 PRO A 67	SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-3.6A) SAM A 401 (-4.3A)	1.08A	2dpmA-1nw5A: 2.3	2dpmA-1nw5A: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_1 (SAM DEPENDENT METHYLTRANSFERASE)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	ASP A 271 ASP A 46 ASP A 65	SAM A 401 (-2.9A) SAM A 401 (-3.6A) SAM A 401 (-3.3A)	0.70A	2igtA-1nw5A: 2.9	2igtA-1nw5A: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	ASP A 271 ASP A 46 ASP A 65	SAM A 401 (-2.9A) SAM A 401 (-3.6A) SAM A 401 (-3.3A)	0.73A	2igtB-1nw5A: 2.9	2igtB-1nw5A: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QM9_B_TDZB202_1 (FATTY ACID-BINDING PROTEIN, ADIPOCYTE)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	VAL A 95 ALA A 90 ILE A 104 CYH A 64 TYR A 81	None	1.42A	2qm9B-1nw5A: undetectable	2qm9B-1nw5A: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_1 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	ASP A 271 ASP A 46 ASP A 65	SAM A 401 (-2.9A) SAM A 401 (-3.6A) SAM A 401 (-3.3A)	0.44A	3douA-1nw5A: 2.8	3douA-1nw5A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_C_SAMC300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	GLY A 252 ASP A 271 ASP A 46	SAM A 401 (-3.3A) SAM A 401 (-2.9A) SAM A 401 (-3.6A)	0.46A	3ou7C-1nw5A: 4.1	3ou7C-1nw5A: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_B_ACTB4_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	GLY A 252 GLY A 254 THR A 256	SAM A 401 (-3.3A) None None	0.36A	3si7B-1nw5A: undetectable	3si7B-1nw5A: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DCM_A_SAMA401_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE G)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 11	ASP A 248 GLY A 252 ILE A 63 ASP A 271 PRO A 67	None SAM A 401 (-3.3A) None SAM A 401 (-2.9A) SAM A 401 (-4.3A)	0.86A	4dcmA-1nw5A: 4.3	4dcmA-1nw5A: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAR_A_ERMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	LEU A 312 VAL A 59 ALA A 260 PHE A 249 THR A 270	None	1.31A	4iarA-1nw5A: undetectable	4iarA-1nw5A: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOS_A_4KOA201_1 (UNCHARACTERIZED PROTEIN)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	GLY A 106 ILE A 159 PHE A 162 ARG A 127 LEU A 134	None	1.17A	4kosA-1nw5A: 0.0	4kosA-1nw5A: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOT_A_CE3A205_1 (UNCHARACTERIZED PROTEIN)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	GLY A 106 ILE A 159 PHE A 162 ARG A 127 LEU A 134	None	1.09A	4kotA-1nw5A: 0.0	4kotA-1nw5A: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOV_A_KOVA204_1 (UNCHARACTERIZED PROTEIN)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	GLY A 106 ILE A 159 PHE A 162 ARG A 127 LEU A 134	None	1.13A	4kovA-1nw5A: 0.0	4kovA-1nw5A: 22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTS_A_SAMA301_0 (DNA ADENINE METHYLASE)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	PHE A 250 GLY A 252 ASP A 271 ASP A 65 PRO A 67	SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.9A) SAM A 401 (-3.3A) SAM A 401 (-4.3A)	0.64A	4rtsA-1nw5A: 2.3	4rtsA-1nw5A: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E72_A_SAMA400_1 (N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	4 / 4	ASP A 248 GLY A 252 ASP A 271 ASP A 46	None SAM A 401 (-3.3A) SAM A 401 (-2.9A) SAM A 401 (-3.6A)	0.33A	5e72A-1nw5A: 2.1	5e72A-1nw5A: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_A_X2NA590_2 (CYP51 VARIANT1)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	PRO A 228 ILE A 102 SER A 211	None	0.81A	5fsaA-1nw5A: undetectable	5fsaA-1nw5A: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_A_SAMA301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	ASP A 46 ASP A 65 PRO A 67 PHE A 250 GLY A 252	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-4.3A) SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.52A	5hfjA-1nw5A: 21.5	5hfjA-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_B_SAMB301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	ASP A 65 PRO A 67 HIS A 223 THR A 225 GLN A 226 PHE A 250 GLY A 252	SAM A 401 (-3.3A) SAM A 401 (-4.3A) SAM A 401 (-4.0A) SAM A 401 (-3.6A) None SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.60A	5hfjB-1nw5A: 20.9	5hfjB-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_B_SAMB301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	PRO A 67 HIS A 223 THR A 225 GLN A 226 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-4.3A) SAM A 401 (-4.0A) SAM A 401 (-3.6A) None SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	0.96A	5hfjB-1nw5A: 20.9	5hfjB-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_C_SAMC301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	ASP A 46 PRO A 67 THR A 225 GLN A 226 LYS A 227 PHE A 250 GLY A 252	SAM A 401 (-3.6A) SAM A 401 (-4.3A) SAM A 401 (-3.6A) None SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.71A	5hfjC-1nw5A: 21.9	5hfjC-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_D_SAMD301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	6 / 12	ASP A 46 ASP A 65 PRO A 67 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-4.3A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	0.68A	5hfjD-1nw5A: 20.1	5hfjD-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_E_SAME301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	6 / 12	ASP A 46 ASP A 65 LYS A 227 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	0.65A	5hfjE-1nw5A: 20.8	5hfjE-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	6 / 12	ASP A 46 ASP A 65 PRO A 67 THR A 225 PHE A 250 GLY A 252	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-4.3A) SAM A 401 (-3.6A) SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.69A	5hfjF-1nw5A: 20.8	5hfjF-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	6 / 12	ASP A 46 ASP A 65 THR A 225 GLN A 226 PHE A 250 GLY A 252	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-3.6A) None SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.68A	5hfjF-1nw5A: 20.8	5hfjF-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	6 / 12	ASP A 46 PRO A 67 THR A 225 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-3.6A) SAM A 401 (-4.3A) SAM A 401 (-3.6A) SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	0.88A	5hfjF-1nw5A: 20.8	5hfjF-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_F_SAMF301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	6 / 12	ASP A 46 THR A 225 GLN A 226 PHE A 250 GLY A 252 SER A 253	SAM A 401 (-3.6A) SAM A 401 (-3.6A) None SAM A 401 (-4.7A) SAM A 401 (-3.3A) SAM A 401 (-2.8A)	1.00A	5hfjF-1nw5A: 20.8	5hfjF-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_G_SAMG301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	ASP A 65 PRO A 67 THR A 225 GLN A 226 LYS A 227 PHE A 250 GLY A 252	SAM A 401 (-3.3A) SAM A 401 (-4.3A) SAM A 401 (-3.6A) None SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.57A	5hfjG-1nw5A: 21.6	5hfjG-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_H_SAMH301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	ASP A 46 ASP A 65 PRO A 67 THR A 225 LYS A 227 PHE A 250 GLY A 252	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-4.3A) SAM A 401 (-3.6A) SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.63A	5hfjH-1nw5A: 20.4	5hfjH-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_H_SAMH301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	7 / 12	ASP A 46 ASP A 65 THR A 225 GLN A 226 LYS A 227 PHE A 250 GLY A 252	SAM A 401 (-3.6A) SAM A 401 (-3.3A) SAM A 401 (-3.6A) None SAM A 401 (-4.4A) SAM A 401 (-4.7A) SAM A 401 (-3.3A)	0.69A	5hfjH-1nw5A: 20.4	5hfjH-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_H_SAMH301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	ASP A 65 THR A 225 LYS A 227 GLY A 252 TYR A 279	SAM A 401 (-3.3A) SAM A 401 (-3.6A) SAM A 401 (-4.4A) SAM A 401 (-3.3A) None	1.39A	5hfjH-1nw5A: 20.4	5hfjH-1nw5A: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGT_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	5 / 12	PRO A 204 LEU A 61 GLY A 100 THR A 99 TYR A 168	None	1.06A	5igtA-1nw5A: undetectable	5igtA-1nw5A: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D9K_F_ACTF802_0 (UNCHARACTERIZED PROTEIN)	1nw5	MODIFICATION METHYLASE RSRI (Rhodobacter sphaeroides)	3 / 3	TYR A 299 ALA A 257 LEU A 284	None	0.73A	6d9kF-1nw5A: 2.2	6d9kF-1nw5A: 18.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EIZ_A_SAMA301_1","FTSJ","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"ASP A 271;ASP A  46;ASP A  65","SAM A 401 (-2.9A);SAM A 401 (-3.6A);SAM A 401 (-3.3A)","0.54A","1eizA-1nw5A:2.8","1eizA-1nw5A:21.43"],["1EJ0_A_SAMA301_1","FTSJ","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"ASP A 271;ASP A  46;ASP A  65","SAM A 401 (-2.9A);SAM A 401 (-3.6A);SAM A 401 (-3.3A)","0.59A","1ej0A-1nw5A:3.1","1ej0A-1nw5A:21.43"],["1G60_A_SAMA500_0","ADENINE-SPECIFIC METHYLTRANSFERASE MBOIIA","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"CYH A  47;ASP A  65;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-3.8A);SAM A 401 (-3.3A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","0.26A","1g60A-1nw5A:25.2","1g60A-1nw5A:32.00"],["1NW5_A_SAMA401_0","MODIFICATION METHYLASE RSRI","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",12,"ASP A  46;CYH A  47;PRO A  67;TRP A  84;THR A 225;LYS A 227;PHE A 250;GLY A 252;SER A 253;VAL A 255;ALA A 272;ALA A 273","SAM A 401 (-3.6A);SAM A 401 (-3.8A);SAM A 401 (-4.3A);None;SAM A 401 (-3.6A);SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A);SAM A 401 (-4.8A);SAM A 401 (-3.5A);SAM A 401 ( 3.7A)","0.02A","1nw5A-1nw5A:46.9","1nw5A-1nw5A:100.00"],["1NW5_A_SAMA401_0","MODIFICATION METHYLASE RSRI","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"CYH A  47;PRO A  66;THR A 225;LYS A 227;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-3.8A);None;SAM A 401 (-3.6A);SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","1.48A","1nw5A-1nw5A:46.9","1nw5A-1nw5A:100.00"],["1NW5_A_SAMA401_1","MODIFICATION METHYLASE RSRI","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"ASP A  65;HIS A 223;ASP A 271","SAM A 401 (-3.3A);SAM A 401 (-4.0A);SAM A 401 (-2.9A)","0.01A","1nw5A-1nw5A:46.9","1nw5A-1nw5A:100.00"],["2DPM_A_SAMA300_0","PROTEIN (ADENINE-SPECIFIC METHYLTRANSFERASE DPNII 1)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"LYS A 227;PHE A 250;GLY A 252;ASP A  46;PRO A  67","SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-3.6A);SAM A 401 (-4.3A)","1.08A","2dpmA-1nw5A:2.3","2dpmA-1nw5A:21.94"],["2IGT_A_SAMA1001_1","SAM DEPENDENT METHYLTRANSFERASE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"ASP A 271;ASP A  46;ASP A  65","SAM A 401 (-2.9A);SAM A 401 (-3.6A);SAM A 401 (-3.3A)","0.70A","2igtA-1nw5A:2.9","2igtA-1nw5A:21.47"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"ASP A 271;ASP A  46;ASP A  65","SAM A 401 (-2.9A);SAM A 401 (-3.6A);SAM A 401 (-3.3A)","0.73A","2igtB-1nw5A:2.9","2igtB-1nw5A:21.47"],["2QM9_B_TDZB202_1","FATTY ACID-BINDING PROTEIN, ADIPOCYTE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"VAL A  95;ALA A  90;ILE A 104;CYH A  64;TYR A  81","None","1.42A","2qm9B-1nw5A:undetectable","2qm9B-1nw5A:20.94"],["3DOU_A_SAMA1_1","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"ASP A 271;ASP A  46;ASP A  65","SAM A 401 (-2.9A);SAM A 401 (-3.6A);SAM A 401 (-3.3A)","0.44A","3douA-1nw5A:2.8","3douA-1nw5A:20.00"],["3OU7_C_SAMC300_1","SAM-DEPENDENT METHYLTRANSFERASE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"GLY A 252;ASP A 271;ASP A  46","SAM A 401 (-3.3A);SAM A 401 (-2.9A);SAM A 401 (-3.6A)","0.46A","3ou7C-1nw5A:4.1","3ou7C-1nw5A:22.63"],["3SI7_B_ACTB4_0","CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"GLY A 252;GLY A 254;THR A 256","SAM A 401 (-3.3A);None;None","0.36A","3si7B-1nw5A:undetectable","3si7B-1nw5A:20.47"],["4DCM_A_SAMA401_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE G","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"ASP A 248;GLY A 252;ILE A  63;ASP A 271;PRO A  67","None;SAM A 401 (-3.3A);None;SAM A 401 (-2.9A);SAM A 401 (-4.3A)","0.86A","4dcmA-1nw5A:4.3","4dcmA-1nw5A:21.74"],["4IAR_A_ERMA2001_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"LEU A 312;VAL A  59;ALA A 260;PHE A 249;THR A 270","None","1.31A","4iarA-1nw5A:undetectable","4iarA-1nw5A:21.15"],["4KOS_A_4KOA201_1","UNCHARACTERIZED PROTEIN","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"GLY A 106;ILE A 159;PHE A 162;ARG A 127;LEU A 134","None","1.17A","4kosA-1nw5A:0.0","4kosA-1nw5A:22.87"],["4KOT_A_CE3A205_1","UNCHARACTERIZED PROTEIN","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"GLY A 106;ILE A 159;PHE A 162;ARG A 127;LEU A 134","None","1.09A","4kotA-1nw5A:0.0","4kotA-1nw5A:22.87"],["4KOV_A_KOVA204_1","UNCHARACTERIZED PROTEIN","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"GLY A 106;ILE A 159;PHE A 162;ARG A 127;LEU A 134","None","1.13A","4kovA-1nw5A:0.0","4kovA-1nw5A:22.87"],["4RTS_A_SAMA301_0","DNA ADENINE METHYLASE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"PHE A 250;GLY A 252;ASP A 271;ASP A  65;PRO A  67","SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.9A);SAM A 401 (-3.3A);SAM A 401 (-4.3A)","0.64A","4rtsA-1nw5A:2.3","4rtsA-1nw5A:21.93"],["5E72_A_SAMA400_1","N2, N2-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",4,"ASP A 248;GLY A 252;ASP A 271;ASP A  46","None;SAM A 401 (-3.3A);SAM A 401 (-2.9A);SAM A 401 (-3.6A)","0.33A","5e72A-1nw5A:2.1","5e72A-1nw5A:21.60"],["5FSA_A_X2NA590_2","CYP51 VARIANT1","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"PRO A 228;ILE A 102;SER A 211","None","0.81A","5fsaA-1nw5A:undetectable","5fsaA-1nw5A:21.33"],["5HFJ_A_SAMA301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"ASP A  46;ASP A  65;PRO A  67;PHE A 250;GLY A 252","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-4.3A);SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.52A","5hfjA-1nw5A:21.5","5hfjA-1nw5A:24.17"],["5HFJ_B_SAMB301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"ASP A  65;PRO A  67;HIS A 223;THR A 225;GLN A 226;PHE A 250;GLY A 252","SAM A 401 (-3.3A);SAM A 401 (-4.3A);SAM A 401 (-4.0A);SAM A 401 (-3.6A);None;SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.60A","5hfjB-1nw5A:20.9","5hfjB-1nw5A:24.17"],["5HFJ_B_SAMB301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"PRO A  67;HIS A 223;THR A 225;GLN A 226;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-4.3A);SAM A 401 (-4.0A);SAM A 401 (-3.6A);None;SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","0.96A","5hfjB-1nw5A:20.9","5hfjB-1nw5A:24.17"],["5HFJ_C_SAMC301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"ASP A  46;PRO A  67;THR A 225;GLN A 226;LYS A 227;PHE A 250;GLY A 252","SAM A 401 (-3.6A);SAM A 401 (-4.3A);SAM A 401 (-3.6A);None;SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.71A","5hfjC-1nw5A:21.9","5hfjC-1nw5A:24.17"],["5HFJ_D_SAMD301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",6,"ASP A  46;ASP A  65;PRO A  67;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-4.3A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","0.68A","5hfjD-1nw5A:20.1","5hfjD-1nw5A:24.17"],["5HFJ_E_SAME301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",6,"ASP A  46;ASP A  65;LYS A 227;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","0.65A","5hfjE-1nw5A:20.8","5hfjE-1nw5A:24.17"],["5HFJ_F_SAMF301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",6,"ASP A  46;ASP A  65;PRO A  67;THR A 225;PHE A 250;GLY A 252","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-4.3A);SAM A 401 (-3.6A);SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.69A","5hfjF-1nw5A:20.8","5hfjF-1nw5A:24.17"],["5HFJ_F_SAMF301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",6,"ASP A  46;ASP A  65;THR A 225;GLN A 226;PHE A 250;GLY A 252","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-3.6A);None;SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.68A","5hfjF-1nw5A:20.8","5hfjF-1nw5A:24.17"],["5HFJ_F_SAMF301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",6,"ASP A  46;PRO A  67;THR A 225;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-3.6A);SAM A 401 (-4.3A);SAM A 401 (-3.6A);SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","0.88A","5hfjF-1nw5A:20.8","5hfjF-1nw5A:24.17"],["5HFJ_F_SAMF301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",6,"ASP A  46;THR A 225;GLN A 226;PHE A 250;GLY A 252;SER A 253","SAM A 401 (-3.6A);SAM A 401 (-3.6A);None;SAM A 401 (-4.7A);SAM A 401 (-3.3A);SAM A 401 (-2.8A)","1.00A","5hfjF-1nw5A:20.8","5hfjF-1nw5A:24.17"],["5HFJ_G_SAMG301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"ASP A  65;PRO A  67;THR A 225;GLN A 226;LYS A 227;PHE A 250;GLY A 252","SAM A 401 (-3.3A);SAM A 401 (-4.3A);SAM A 401 (-3.6A);None;SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.57A","5hfjG-1nw5A:21.6","5hfjG-1nw5A:24.17"],["5HFJ_H_SAMH301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"ASP A  46;ASP A  65;PRO A  67;THR A 225;LYS A 227;PHE A 250;GLY A 252","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-4.3A);SAM A 401 (-3.6A);SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.63A","5hfjH-1nw5A:20.4","5hfjH-1nw5A:24.17"],["5HFJ_H_SAMH301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",7,"ASP A  46;ASP A  65;THR A 225;GLN A 226;LYS A 227;PHE A 250;GLY A 252","SAM A 401 (-3.6A);SAM A 401 (-3.3A);SAM A 401 (-3.6A);None;SAM A 401 (-4.4A);SAM A 401 (-4.7A);SAM A 401 (-3.3A)","0.69A","5hfjH-1nw5A:20.4","5hfjH-1nw5A:24.17"],["5HFJ_H_SAMH301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"ASP A  65;THR A 225;LYS A 227;GLY A 252;TYR A 279","SAM A 401 (-3.3A);SAM A 401 (-3.6A);SAM A 401 (-4.4A);SAM A 401 (-3.3A);None","1.39A","5hfjH-1nw5A:20.4","5hfjH-1nw5A:24.17"],["5IGT_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",5,"PRO A 204;LEU A  61;GLY A 100;THR A  99;TYR A 168","None","1.06A","5igtA-1nw5A:undetectable","5igtA-1nw5A:22.51"],["6D9K_F_ACTF802_0","UNCHARACTERIZED PROTEIN","1nw5","MODIFICATION METHYLASE RSRI","Rhodobacter sphaeroides",3,"TYR A 299;ALA A 257;LEU A 284","None","0.73A","6d9kF-1nw5A:2.2","6d9kF-1nw5A:18.59"]]