SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.87A 1a7yB-1nwaA:
undetectable		 1a7yB-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.87A 1dscC-1nwaA:
undetectable		 1dscC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.59A 1dscC-1nwaA:
undetectable		 1dscC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.72A 1fjaC-1nwaA:
undetectable		 1fjaC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.72A 1fjaD-1nwaA:
undetectable		 1fjaD-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.85A 1i3wE-1nwaA:
undetectable		 1i3wE-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.82A 1i3wG-1nwaA:
undetectable		 1i3wG-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.83A 1i3wH-1nwaA:
undetectable		 1i3wH-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.85A 1mnvD-1nwaA:
undetectable		 1mnvD-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.79A 1mnvD-1nwaA:
undetectable		 1mnvD-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.87A 1ovfB-1nwaA:
undetectable		 1ovfB-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  10
LEU A   9
ILE A  96
SER A  94
 None
 1.03A 1sbrA-1nwaA:
0.3
1sbrB-1nwaA:
0.7		 1sbrA-1nwaA:
20.17
1sbrB-1nwaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.87A 1unjL-1nwaA:
undetectable		 1unjL-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.81A 1unjL-1nwaA:
undetectable		 1unjL-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.85A 1unjR-1nwaA:
undetectable		 1unjR-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.85A 1unjR-1nwaA:
undetectable		 1unjR-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.76A 1unjW-1nwaA:
undetectable		 1unjW-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.84A 1unjX-1nwaA:
undetectable		 1unjX-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.84A 1unjX-1nwaA:
undetectable		 1unjX-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.81A 1unmE-1nwaA:
undetectable		 1unmE-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.77A 1unmE-1nwaA:
undetectable		 1unmE-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.83A 1unmF-1nwaA:
undetectable		 1unmF-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.79A 1unmF-1nwaA:
undetectable		 1unmF-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  61
THR A  63
PRO A  60
 None
 0.85A 209dC-1nwaA:
undetectable		 209dC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 134
SER A  35
GLY A  33
ARG A  31
 None
 1.20A 2f7fA-1nwaA:
2.1		 2f7fA-1nwaA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.87A 316dC-1nwaA:
undetectable		 316dC-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  52
ALA A  53
GLY A  33
LEU A  17
GLY A  36
 None
 1.02A 3g2oA-1nwaA:
undetectable		 3g2oA-1nwaA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  52
ALA A  53
GLY A  33
LEU A  17
GLY A  36
 None
 1.05A 3g2oB-1nwaA:
undetectable		 3g2oB-1nwaA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  75
GLN A  74
VAL A 157
PHE A  71
 None
 1.46A 3ieoA-1nwaA:
0.0		 3ieoA-1nwaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 112
LEU A 108
VAL A 124
ILE A  96
PHE A  73
 None
 1.28A 3jw5A-1nwaA:
undetectable		 3jw5A-1nwaA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		5 / 11 GLU A  70
ILE A  56
PHE A  72
ALA A   7
ASP A  64
 None
 1.07A 3nmuB-1nwaA:
undetectable
3nmuJ-1nwaA:
undetectable		 3nmuB-1nwaA:
20.48
3nmuJ-1nwaA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  63
PRO A  60
THR A  61
 None
 0.88A 4hivD-1nwaA:
undetectable		 4hivD-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  54
LEU A   9
ILE A  56
PHE A  73
 None
 0.88A 4r38D-1nwaA:
undetectable		 4r38D-1nwaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		4 / 8 SER A  94
ALA A  95
HIS A  76
LEU A  69
 None
 1.21A 5dzkF-1nwaA:
0.0
5dzkT-1nwaA:
undetectable		 5dzkF-1nwaA:
20.08
5dzkT-1nwaA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  68
PHE A  71
TYR A  65
ILE A  56
ALA A   7
 None
 1.03A 5j7wD-1nwaA:
0.0		 5j7wD-1nwaA:
20.75