SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		5 / 12 PHE A 115
THR A  29
ILE A  32
LEU A  36
THR A  81
 None
 1.16A 1dhfA-1nx8A:
undetectable		 1dhfA-1nx8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		5 / 10 PHE A 115
THR A  29
ILE A  32
LEU A  36
THR A  81
 None
 1.22A 2w3aB-1nx8A:
undetectable		 2w3aB-1nx8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		5 / 9 THR A 154
GLU A 153
VAL A 207
PHE A 217
GLU A 213
 None
 1.33A 2w98A-1nx8A:
undetectable		 2w98A-1nx8A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A 241
PHE A 115
THR A  29
ILE A  32
LEU A  36
 None
 1.12A 4qlgB-1nx8A:
undetectable		 4qlgB-1nx8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		5 / 12 ASP A  20
ILE A  19
ALA A  17
VAL A  42
PHE A  24
 None
 1.04A 4u8vB-1nx8A:
undetectable		 4u8vB-1nx8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		4 / 5 TYR A 230
PHE A 192
HIS A 135
LEU A 150
 None
 1.29A 5csyB-1nx8A:
undetectable		 5csyB-1nx8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		4 / 6 TYR A 232
ASP A 240
HIS A 234
ILE A 243
 None
 1.19A 5ih0A-1nx8A:
undetectable		 5ih0A-1nx8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1nx8 CARBAPENEM SYNTHASE
(Pectobacterium
carotovorum) 		4 / 5 HIS A 101
ASP A 103
HIS A 251
ARG A 267
 FE  A 300 ( 3.3A)
FE  A 300 ( 2.4A)
FE  A 300 ( 3.3A)
AKG  A 280 (-3.9A)
 0.80A 6dchA-1nx8A:
19.1		 6dchA-1nx8A:
24.71