SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  30
LEU A 105
ARG A  86
GLY A 107
 None
 0.76A 1jhvA-1nxjA:
undetectable		 1jhvA-1nxjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 153
VAL A 156
GLY A 137
VAL A  19
ILE A 155
 GLV  A 741 ( 4.5A)
None
None
None
None
 0.93A 2ienA-1nxjA:
undetectable		 2ienA-1nxjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  37
VAL A  65
ILE A 155
VAL A 142
ILE A  39
 None
 0.97A 2ienB-1nxjA:
undetectable		 2ienB-1nxjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 135
VAL A 156
ASP A 145
ILE A  39
 None
 0.93A 2qbmA-1nxjA:
undetectable		 2qbmA-1nxjA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  92
GLY A  62
ILE A  39
VAL A  65
LEU A  93
VAL A  77
 None
None
None
None
None
TLA  A 391 ( 4.8A)
 1.45A 2yqzB-1nxjA:
undetectable		 2yqzB-1nxjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  26
ILE A  94
GLY A 153
CYH A  22
 None
None
GLV  A 741 ( 4.5A)
None
 1.33A 3r0lD-1nxjA:
undetectable		 3r0lD-1nxjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 112
ILE A 108
VAL A  63
VAL A  65
LEU A  55
 None
 1.31A 5jkwA-1nxjA:
undetectable		 5jkwA-1nxjA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  97
LEU A 115
HIS A  96
 None
 0.66A 5u63B-1nxjA:
undetectable		 5u63B-1nxjA:
19.82