SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 ALA A  75
VAL A 109
TRP A  79
 None
 0.85A 1c4dC-1nxuA:
undetectable
1c4dD-1nxuA:
undetectable		 1c4dC-1nxuA:
2.72
1c4dD-1nxuA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 TRP A  79
ALA A  75
VAL A 109
 None
 0.82A 1c4dC-1nxuA:
undetectable
1c4dD-1nxuA:
undetectable		 1c4dC-1nxuA:
2.72
1c4dD-1nxuA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 SER A  39
ASP A 172
CYH A 136
 None
 0.93A 2br4E-1nxuA:
undetectable		 2br4E-1nxuA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 6 SER A  43
GLY A  45
THR A  36
ARG A 119
 None
 1.25A 2f7fA-1nxuA:
undetectable		 2f7fA-1nxuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 ASP A  60
ASN A 115
THR A 138
 None
 0.73A 2q63B-1nxuA:
undetectable		 2q63B-1nxuA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		5 / 9 LEU A 240
ILE A 160
GLY A 134
ILE A 266
ILE A 262
 None
 1.17A 2r5qA-1nxuA:
undetectable		 2r5qA-1nxuA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		5 / 9 LEU A 240
ILE A 160
GLY A 134
ILE A 266
ILE A 262
 None
 1.17A 2r5qC-1nxuA:
undetectable		 2r5qC-1nxuA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 ARG A  69
GLU A  77
SER A  84
 None
 0.91A 2xctD-1nxuA:
0.0		 2xctD-1nxuA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 ARG A  96
GLU A  99
SER A  84
 None
 0.86A 2xctD-1nxuA:
0.0		 2xctD-1nxuA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 ASN A  13
MET A 118
PHE A  49
 None
 1.02A 3g4lD-1nxuA:
0.0		 3g4lD-1nxuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 6 LEU A 188
VAL A 185
MET A 182
VAL A 325
 None
None
SO4  A1002 (-4.8A)
None
 1.06A 3soaA-1nxuA:
undetectable		 3soaA-1nxuA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 8 ILE A  98
GLU A  99
ILE A 135
LEU A 108
 None
 0.91A 4mj8A-1nxuA:
undetectable		 4mj8A-1nxuA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 5 ILE A 319
ARG A 316
GLU A  38
VAL A  41
 None
 1.11A 4nkxC-1nxuA:
0.0		 4nkxC-1nxuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 5 ILE A 319
ARG A 316
GLU A  38
VAL A  41
 None
 1.13A 4nkxD-1nxuA:
0.0		 4nkxD-1nxuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 SER A 260
ALA A 110
VAL A 109
 None
 0.46A 4x20C-1nxuA:
undetectable		 4x20C-1nxuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 5 ILE A  98
ILE A 266
TYR A 132
GLU A 267
 None
 1.27A 4zzcE-1nxuA:
undetectable		 4zzcE-1nxuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 8 HIS A  44
GLY A 121
GLY A 120
VAL A  41
 SO4  A1001 (-4.1A)
None
None
None
 0.73A 5f8yA-1nxuA:
undetectable		 5f8yA-1nxuA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		4 / 8 HIS A  44
GLY A 121
GLY A 120
VAL A  41
 SO4  A1001 (-4.1A)
None
None
None
 0.65A 5f8yB-1nxuA:
undetectable		 5f8yB-1nxuA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK
(Escherichia
coli) 		3 / 3 ARG A 315
LEU A 311
PHE A 307
 None
 0.81A 6nknP-1nxuA:
undetectable		 6nknP-1nxuA:
20.28