SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ny5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 10 LEU A 235
ILE A 275
LEU A 296
LEU A 243
VAL A 196
 None
 0.99A 1cqpA-1ny5A:
5.1
1cqpB-1ny5A:
5.2		 1cqpA-1ny5A:
18.41
1cqpB-1ny5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		3 / 3 ASP A   8
LEU A  52
LEU A  54
 None
 0.67A 1ikeA-1ny5A:
undetectable		 1ikeA-1ny5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		3 / 3 ASP A   8
LEU A  52
LEU A  54
 None
 0.74A 1np1B-1ny5A:
0.0		 1np1B-1ny5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 VAL A 362
ILE A 363
ILE A 375
PHE A 339
VAL A 384
 None
 0.94A 1qhsA-1ny5A:
3.8		 1qhsA-1ny5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 VAL A 362
ILE A 363
ILE A 375
PHE A 339
VAL A 384
 None
 0.97A 1qhyA-1ny5A:
3.5		 1qhyA-1ny5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 1.02A 2eimP-1ny5A:
undetectable
2eimW-1ny5A:
undetectable		 2eimP-1ny5A:
19.75
2eimW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 8 LEU A 208
ALA A 247
GLY A 210
LEU A 263
ASP A 202
 None
 1.28A 2yfxA-1ny5A:
undetectable		 2yfxA-1ny5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.94A 3ag4P-1ny5A:
undetectable
3ag4W-1ny5A:
undetectable		 3ag4P-1ny5A:
19.75
3ag4W-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 1.00A 3asnP-1ny5A:
undetectable
3asnW-1ny5A:
undetectable		 3asnP-1ny5A:
19.75
3asnW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.96A 3asoC-1ny5A:
undetectable
3asoJ-1ny5A:
undetectable		 3asoC-1ny5A:
19.75
3asoJ-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.99A 3asoP-1ny5A:
undetectable
3asoW-1ny5A:
undetectable		 3asoP-1ny5A:
19.75
3asoW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 8 LEU A 183
LEU A 150
ILE A 305
VAL A 176
LEU A 179
 None
 1.40A 3kp6A-1ny5A:
undetectable
3kp6B-1ny5A:
undetectable		 3kp6A-1ny5A:
20.67
3kp6B-1ny5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 ILE A 240
ILE A 275
SER A 244
LEU A 208
 None
 0.80A 3ua5A-1ny5A:
undetectable		 3ua5A-1ny5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.98A 3wg7C-1ny5A:
undetectable
3wg7J-1ny5A:
0.0		 3wg7C-1ny5A:
19.75
3wg7J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.39A 4cevA-1ny5A:
undetectable
4cevB-1ny5A:
undetectable		 4cevA-1ny5A:
23.75
4cevB-1ny5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.39A 4cevB-1ny5A:
0.2
4cevC-1ny5A:
0.2		 4cevB-1ny5A:
23.75
4cevC-1ny5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 MET A 146
ASP A 316
ARG A 313
GLU A 315
 None
 1.39A 4cevA-1ny5A:
undetectable
4cevC-1ny5A:
undetectable		 4cevA-1ny5A:
23.75
4cevC-1ny5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.42A 4cevD-1ny5A:
undetectable
4cevE-1ny5A:
undetectable		 4cevD-1ny5A:
23.75
4cevE-1ny5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 ARG A 313
GLU A 315
MET A 146
ASP A 316
 None
 1.42A 4cevE-1ny5A:
0.3
4cevF-1ny5A:
0.9		 4cevE-1ny5A:
23.75
4cevF-1ny5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 MET A 146
ASP A 316
ARG A 313
GLU A 315
 None
 1.40A 4cevD-1ny5A:
0.2
4cevF-1ny5A:
0.9		 4cevD-1ny5A:
23.75
4cevF-1ny5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 ILE A 240
PHE A 204
LEU A 243
PHE A 227
 None
 0.89A 4qopC-1ny5A:
undetectable		 4qopC-1ny5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 4 ASN A 282
VAL A 287
THR A 279
ILE A 240
 None
 1.39A 4retA-1ny5A:
3.5		 4retA-1ny5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 4 ASN A 282
VAL A 287
THR A 279
ILE A 240
 None
 1.39A 4retC-1ny5A:
undetectable		 4retC-1ny5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 ALA A  87
LEU A  52
LEU A  53
ILE A  84
 None
 0.85A 4ubsA-1ny5A:
0.0		 4ubsA-1ny5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 LEU A 380
ALA A 321
ASN A 322
ILE A 318
 None
 1.03A 4y03B-1ny5A:
undetectable		 4y03B-1ny5A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.87A 5b1bP-1ny5A:
undetectable
5b1bW-1ny5A:
0.0		 5b1bP-1ny5A:
19.75
5b1bW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 LYS A 101
PHE A  98
VAL A   5
ASP A  51
 None
 1.18A 5hesA-1ny5A:
undetectable		 5hesA-1ny5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 12 LEU A 320
ALA A 321
PHE A 324
PHE A 339
LEU A 380
 None
 1.05A 5k9dA-1ny5A:
1.8		 5k9dA-1ny5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 8 ILE A 112
ALA A 115
ILE A 116
GLU A  74
 None
 0.70A 5mvmA-1ny5A:
0.0
5mvmB-1ny5A:
0.0		 5mvmA-1ny5A:
11.69
5mvmB-1ny5A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.96A 5x19C-1ny5A:
undetectable
5x19J-1ny5A:
undetectable		 5x19C-1ny5A:
19.75
5x19J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.90A 5x1fP-1ny5A:
undetectable
5x1fW-1ny5A:
undetectable		 5x1fP-1ny5A:
19.75
5x1fW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.84A 5z84C-1ny5A:
0.0
5z84J-1ny5A:
undetectable		 5z84C-1ny5A:
19.75
5z84J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.81A 5z85C-1ny5A:
undetectable
5z85J-1ny5A:
0.0		 5z85C-1ny5A:
19.75
5z85J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.79A 5zcoC-1ny5A:
undetectable
5zcoJ-1ny5A:
0.0		 5zcoC-1ny5A:
19.75
5zcoJ-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.83A 5zcqC-1ny5A:
undetectable
5zcqJ-1ny5A:
0.0		 5zcqC-1ny5A:
19.75
5zcqJ-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 7 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.84A 5zcqP-1ny5A:
undetectable
5zcqW-1ny5A:
0.0		 5zcqP-1ny5A:
19.75
5zcqW-1ny5A:
9.82