SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 PHE A 213
ILE A 217
PRO A 209
LEU A 106
 None
 0.87A 1hmyA-1nylA:
undetectable		 1hmyA-1nylA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 ASP A 527
HIS A 530
ARG A 470
GLU A 283
 None
 1.27A 1lqtA-1nylA:
1.0		 1lqtA-1nylA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A 331
LEU A 327
VAL A 542
GLU A 323
ILE A 313
 None
 1.09A 2vn0A-1nylA:
0.0		 2vn0A-1nylA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLY A 501
TRP A 386
VAL A 459
 None
 0.76A 3n65B-1nylA:
undetectable		 3n65B-1nylA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLY A 482
ILE A 491
VAL A 490
 None
 0.43A 3nv6A-1nylA:
undetectable		 3nv6A-1nylA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ASN A 355
GLU A 361
TYR A 415
PHE A 381
 None
 0.96A 3rqwI-1nylA:
undetectable
3rqwJ-1nylA:
undetectable		 3rqwI-1nylA:
21.61
3rqwJ-1nylA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 GLU A 361
TYR A 415
PHE A 381
ASN A 355
 None
 0.95A 3rqwF-1nylA:
undetectable
3rqwJ-1nylA:
undetectable		 3rqwF-1nylA:
21.61
3rqwJ-1nylA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ILE A 331
TRP A  87
SER A 305
ILE A 306
 None
 1.00A 3sfeB-1nylA:
undetectable
3sfeC-1nylA:
undetectable		 3sfeB-1nylA:
20.26
3sfeC-1nylA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A 161
PRO A 209
PHE A 157
 None
 1.01A 3thrC-1nylA:
1.2		 3thrC-1nylA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 THR A 436
ILE A 417
LYS A 418
PHE A 381
 None
 1.38A 4ac9C-1nylA:
2.1		 4ac9C-1nylA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 THR A 436
ILE A 417
LYS A 418
PHE A 381
 None
 1.40A 4acaC-1nylA:
2.0		 4acaC-1nylA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 THR A 436
ILE A 417
LYS A 418
PHE A 381
 None
 1.50A 4acbC-1nylA:
2.1		 4acbC-1nylA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 HIS A 198
ASP A  66
SER A  99
PRO A 209
 None
 1.25A 4apjA-1nylA:
undetectable
4apjP-1nylA:
undetectable		 4apjA-1nylA:
22.72
4apjP-1nylA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 471
PHE A 524
GLU A 521
HIS A 457
ASP A 388
 None
 1.40A 4aqlA-1nylA:
undetectable		 4aqlA-1nylA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 TYR A 102
ARG A  64
SER A  99
 None
 0.92A 4dr2I-1nylA:
undetectable
4dr2J-1nylA:
undetectable		 4dr2I-1nylA:
13.13
4dr2J-1nylA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 518
ALA A 344
PRO A 536
LEU A 507
 None
 0.97A 4dtzA-1nylA:
0.0		 4dtzA-1nylA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 PHE A 518
ALA A 344
PRO A 536
LEU A 507
 None
 0.96A 4dubA-1nylA:
undetectable		 4dubA-1nylA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 ALA A 461
ILE A 387
LEU A 351
LYS A 350
 None
 1.19A 4g19A-1nylA:
undetectable		 4g19A-1nylA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 TYR A 523
HIS A 368
ARG A 341
 None
 0.83A 4htfA-1nylA:
1.8		 4htfA-1nylA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 CYH A 435
ASN A 355
LYS A 418
 None
 1.31A 4k50A-1nylA:
0.0		 4k50A-1nylA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 ARG A 393
TYR A 400
ASP A 347
ARG A 520
 None
 1.42A 4kr4C-1nylA:
0.0		 4kr4C-1nylA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ARG A 474
GLY A 482
ALA A 484
ASP A 485
VAL A 490
 None
 1.04A 4l1aA-1nylA:
undetectable		 4l1aA-1nylA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASN A 355
GLU A 361
TYR A 415
PHE A 381
 None
 0.76A 4twdB-1nylA:
undetectable
4twdC-1nylA:
undetectable		 4twdB-1nylA:
19.37
4twdC-1nylA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 ASN A 355
GLU A 361
TYR A 415
PHE A 381
 None
 0.88A 4twdC-1nylA:
0.0
4twdD-1nylA:
0.0		 4twdC-1nylA:
19.37
4twdD-1nylA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASN A 355
GLU A 361
TYR A 415
PHE A 381
 None
 0.75A 4twdD-1nylA:
0.0
4twdE-1nylA:
undetectable		 4twdD-1nylA:
19.37
4twdE-1nylA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASN A 355
GLU A 361
TYR A 415
PHE A 381
 None
 0.71A 4twdG-1nylA:
0.0
4twdH-1nylA:
0.0		 4twdG-1nylA:
19.37
4twdH-1nylA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASN A 355
GLU A 361
TYR A 415
PHE A 381
 None
 0.78A 4twdI-1nylA:
0.0
4twdJ-1nylA:
0.0		 4twdI-1nylA:
19.37
4twdJ-1nylA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 THR A 230
ASN A  50
PHE A  31
PRO A  32
 None
 1.15A 5v4vA-1nylA:
undetectable		 5v4vA-1nylA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 THR A 230
ASN A  50
PHE A  31
PRO A  32
 None
 1.16A 5v4vB-1nylA:
undetectable		 5v4vB-1nylA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLY A 501
TRP A 386
VAL A 459
 None
 0.76A 5vuoB-1nylA:
undetectable		 5vuoB-1nylA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 VAL A 121
ASP A 122
GLU A 123
GLY A 168
 None
 0.94A 5w3jB-1nylA:
undetectable		 5w3jB-1nylA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 1nyl GLUTAMINYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 4 ILE A  81
LEU A  88
HIS A  40
ALA A  44
 None
 1.01A 6ck2C-1nylA:
undetectable
6ck2D-1nylA:
undetectable		 6ck2C-1nylA:
5.64
6ck2D-1nylA:
4.21