SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 5 LEU A 543
LEU A 531
SER A 487
LEU A 486
 None
 1.03A 1a4lC-1nyqA:
undetectable		 1a4lC-1nyqA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 10 ARG A 421
SER A 423
ALA A 465
ALA A 466
THR A 488
 None
None
None
None
TSB  A1002 ( 4.5A)
 1.19A 1gtnB-1nyqA:
0.0
1gtnC-1nyqA:
0.0		 1gtnB-1nyqA:
7.93
1gtnC-1nyqA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 10 ARG A 421
SER A 423
ALA A 465
ALA A 466
THR A 488
 None
None
None
None
TSB  A1002 ( 4.5A)
 1.19A 1gtnH-1nyqA:
0.0
1gtnI-1nyqA:
0.0		 1gtnH-1nyqA:
7.93
1gtnI-1nyqA:
7.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		10 / 10 MET A 334
CYH A 336
MET A 363
ARG A 365
LEU A 383
ASP A 385
HIS A 387
TYR A 468
GLN A 490
HIS A 517
 TSB  A1002 (-3.2A)
ZN  A1001 ( 2.1A)
TSB  A1002 ( 4.1A)
TSB  A1002 (-2.5A)
TSB  A1002 (-4.6A)
TSB  A1002 (-3.1A)
ZN  A1001 ( 3.3A)
None
TSB  A1002 (-3.6A)
ZN  A1001 ( 3.0A)
 0.42A 1nyrA-1nyqA:
59.1		 1nyrA-1nyqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		10 / 10 MET A 334
CYH A 336
MET A 363
ARG A 365
LEU A 383
ASP A 385
HIS A 387
TYR A 468
GLN A 490
HIS A 517
 TSB  A1002 (-3.2A)
ZN  A1001 ( 2.1A)
TSB  A1002 ( 4.1A)
TSB  A1002 (-2.5A)
TSB  A1002 (-4.6A)
TSB  A1002 (-3.1A)
ZN  A1001 ( 3.3A)
None
TSB  A1002 (-3.6A)
ZN  A1001 ( 3.0A)
 0.60A 1nyrB-1nyqA:
53.8		 1nyrB-1nyqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 ASP A 452
PHE A 399
ASN A 445
 None
 0.68A 1sg9B-1nyqA:
undetectable		 1sg9B-1nyqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.84A 1xwfA-1nyqA:
0.0		 1xwfA-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.82A 1xwfB-1nyqA:
0.0		 1xwfB-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.85A 1xwfC-1nyqA:
0.0		 1xwfC-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 THR A 523
GLU A 484
HIS A 243
 TSB  A1002 (-2.9A)
None
None
 0.80A 1xwfD-1nyqA:
2.1		 1xwfD-1nyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 PHE A 539
PHE A 253
GLY A 270
THR A 272
LEU A 265
 None
 1.23A 2zifA-1nyqA:
undetectable		 2zifA-1nyqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 GLU A 359
HIS A 339
THR A 295
 None
 0.80A 3hkuA-1nyqA:
undetectable		 3hkuA-1nyqA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 7 TYR A 304
MET A 341
LEU A 501
LEU A 303
 None
 1.30A 3nk2X-1nyqA:
0.0		 3nk2X-1nyqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 7 TYR A 106
ASP A 179
ARG A 182
HIS A  79
 None
 1.46A 3zodA-1nyqA:
0.0		 3zodA-1nyqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 8 ARG A 365
THR A 488
THR A 523
ARG A 526
 TSB  A1002 (-2.5A)
TSB  A1002 ( 4.5A)
TSB  A1002 (-2.9A)
TSB  A1002 (-3.5A)
 0.70A 4k87A-1nyqA:
27.3		 4k87A-1nyqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 5 PHE A 530
PHE A 527
LEU A 252
PRO A 545
 None
 0.76A 4o8zA-1nyqA:
undetectable		 4o8zA-1nyqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 ALA A 489
VAL A 403
ALA A 450
ASP A 452
GLY A 455
 None
 0.93A 4v04B-1nyqA:
undetectable		 4v04B-1nyqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 6 ILE A 550
LYS A 628
LEU A 569
GLU A 568
 None
 0.87A 4w5nA-1nyqA:
undetectable		 4w5nA-1nyqA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 TYR A 468
PHE A 493
ASN A 335
LEU A 383
MET A 363
 None
None
None
TSB  A1002 (-4.6A)
TSB  A1002 ( 4.1A)
 1.40A 5l7iA-1nyqA:
0.0		 5l7iA-1nyqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 9 ILE A  29
LYS A  14
ILE A   6
ILE A   4
 None
 0.79A 5vkqB-1nyqA:
0.0
5vkqC-1nyqA:
0.0		 5vkqB-1nyqA:
17.09
5vkqC-1nyqA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 GLU A 367
PRO A 333
ARG A 365
HIS A 387
THR A 488
 TSB  A1002 ( 3.9A)
None
TSB  A1002 (-2.5A)
ZN  A1001 ( 3.3A)
TSB  A1002 ( 4.5A)
 1.37A 5xioB-1nyqA:
27.3		 5xioB-1nyqA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 PRO A 333
ARG A 365
HIS A 387
THR A 488
GLY A 519
 None
TSB  A1002 (-2.5A)
ZN  A1001 ( 3.3A)
TSB  A1002 ( 4.5A)
TSB  A1002 ( 4.5A)
 0.75A 5xipA-1nyqA:
27.4		 5xipA-1nyqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		5 / 12 PRO A 333
ARG A 365
HIS A 387
THR A 488
GLY A 519
 None
TSB  A1002 (-2.5A)
ZN  A1001 ( 3.3A)
TSB  A1002 ( 4.5A)
TSB  A1002 ( 4.5A)
 0.75A 5xiqD-1nyqA:
27.5		 5xiqD-1nyqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 5 GLY A 380
ARG A 379
GLN A 376
MET A 480
 None
 1.40A 5zrfB-1nyqA:
undetectable		 5zrfB-1nyqA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		3 / 3 HIS A 339
ASN A 335
LEU A 383
 None
None
TSB  A1002 (-4.6A)
 0.90A 6f7lB-1nyqA:
undetectable		 6f7lB-1nyqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1nyq THREONYL-TRNA
SYNTHETASE 1
(Staphylococcus
aureus) 		4 / 8 ASP A 385
ARG A 518
HIS A 387
GLU A 285
 TSB  A1002 (-3.1A)
None
ZN  A1001 ( 3.3A)
None
 1.18A 6mn4D-1nyqA:
undetectable		 6mn4D-1nyqA:
18.10