SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ILE A 125
ASP A 212
LEU A 223
PHE A 222
ILE A 208
 None
 1.35A 1rh3A-1nytA:
undetectable		 1rh3A-1nytA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A 103
GLY A 105
LEU A 241
GLY A 239
ARG A 112
 None
None
NAP  A1401 (-4.0A)
None
None
 1.10A 1y4lA-1nytA:
undetectable		 1y4lA-1nytA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 LEU A 106
ILE A 116
ILE A 185
ILE A 122
 None
 0.79A 2bu8A-1nytA:
undetectable		 2bu8A-1nytA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 10 LEU A 141
GLY A 119
LEU A 120
ILE A 122
LEU A 110
 None
 1.04A 2f8dA-1nytA:
0.0		 2f8dA-1nytA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 10 LEU A 141
GLY A 119
LEU A 120
ILE A 122
LEU A 110
 None
 1.05A 2f8dB-1nytA:
2.5		 2f8dB-1nytA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ALA A 159
VAL A 145
THR A 146
THR A 148
 None
 1.18A 2kotB-1nytA:
0.0		 2kotB-1nytA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ILE A 208
CYH A 226
PRO A 197
ILE A 125
 None
 0.92A 2q83B-1nytA:
undetectable		 2q83B-1nytA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		3 / 3 LEU A 139
LEU A 136
ARG A 132
 None
 0.66A 3hcnB-1nytA:
3.8		 3hcnB-1nytA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A 154
GLY A  83
ALA A  84
PRO A  63
 NAP  A1401 (-4.0A)
None
None
NAP  A1401 ( 4.7A)
 0.81A 4eyrB-1nytA:
undetectable		 4eyrB-1nytA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ARG A 154
GLY A  83
ALA A  84
ILE A  44
PRO A  63
 NAP  A1401 (-4.0A)
None
None
None
NAP  A1401 ( 4.7A)
 1.04A 4l1aA-1nytA:
undetectable		 4l1aA-1nytA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A  68
LEU A  96
ASP A 102
ASN A 100
TYR A  33
 None
None
DTV  A1405 ( 2.9A)
None
None
 0.84A 4pclA-1nytA:
5.6		 4pclA-1nytA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASN A  86
LEU A  47
PHE A  69
 DTV  A1405 (-4.0A)
None
None
 0.81A 5dsgA-1nytA:
undetectable		 5dsgA-1nytA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 10 LEU A 241
GLN A  26
PHE A  23
LEU A 266
LEU A 270
 NAP  A1401 (-4.0A)
None
None
None
None
 1.22A 5fhzC-1nytA:
4.3		 5fhzC-1nytA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A  78
GLY A  98
THR A  76
ASN A  86
 None
None
None
DTV  A1405 (-4.0A)
 1.06A 5hwaA-1nytA:
undetectable		 5hwaA-1nytA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 6 PRO A 261
PRO A 257
LEU A 256
LEU A  27
 None
 1.13A 5tl8A-1nytA:
0.0		 5tl8A-1nytA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 9 ILE A 199
PHE A 181
SER A 202
SER A 201
THR A 148
 None
 0.97A 6awpA-1nytA:
0.0		 6awpA-1nytA:
20.00