SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1nzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		4 / 7 ALA A   6
GLU A   5
LEU A   8
VAL A  12
 None
 0.94A 1hk2A-1nznA:
2.7		 1hk2A-1nznA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		3 / 3 LEU A  94
VAL A  97
LEU A 101
 None
 0.51A 1mz9B-1nznA:
undetectable		 1mz9B-1nznA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		5 / 11 GLU A  10
VAL A  14
LEU A  17
TYR A  50
ASP A  53
 None
None
None
GOL  A 301 (-4.9A)
None
 1.41A 2z9xB-1nznA:
undetectable		 2z9xB-1nznA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		5 / 12 TYR A  96
GLY A  83
ALA A  81
ILE A  54
LEU A  61
 None
 1.10A 4aztA-1nznA:
undetectable		 4aztA-1nznA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		5 / 12 TYR A  96
GLY A  83
ALA A  81
ILE A  54
LEU A  61
 None
 1.12A 4azwA-1nznA:
undetectable		 4azwA-1nznA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		3 / 3 VAL A  33
SER A  34
THR A  37
 None
 0.30A 4luhA-1nznA:
3.9		 4luhA-1nznA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1nzn FISSION PROTEIN
FIS1P
(Homo
sapiens) 		3 / 3 LEU A 116
LEU A 100
ASN A 108
 None
 0.69A 4otwA-1nznA:
undetectable		 4otwA-1nznA:
19.38