SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		5 / 8 GLU A 164
ILE A 212
GLU A 226
ALA A 227
VAL A 205
 None
 1.17A 1a29A-1o0wA:
undetectable		 1a29A-1o0wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		3 / 3 GLU A 226
TYR A 169
PHE A 155
 None
 0.93A 1eqbA-1o0wA:
undetectable		 1eqbA-1o0wA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		3 / 3 GLU A 226
TYR A 169
PHE A 155
 None
 0.94A 1eqbD-1o0wA:
undetectable		 1eqbD-1o0wA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		3 / 3 GLU A 226
TYR A 169
PHE A 155
 None
 0.94A 1eqbC-1o0wA:
undetectable		 1eqbC-1o0wA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		4 / 4 GLY A 110
SER A  34
ILE A 124
HIS A  32
 None
 1.23A 1yajJ-1o0wA:
undetectable		 1yajJ-1o0wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		4 / 5 LEU A 125
GLY A 110
ALA A 128
ILE A 124
 None
 0.85A 2aohB-1o0wA:
undetectable		 2aohB-1o0wA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		5 / 12 LEU A 125
GLY A 117
GLY A 110
ALA A 128
ILE A 124
 None
 0.83A 2nmzA-1o0wA:
undetectable		 2nmzA-1o0wA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		5 / 12 LEU A 125
GLY A 117
GLY A 110
ALA A 128
ILE A 124
 None
 0.83A 2nmzB-1o0wA:
undetectable		 2nmzB-1o0wA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		4 / 7 VAL A  93
ILE A 157
TYR A 156
ILE A 160
 None
 0.82A 3hgxA-1o0wA:
undetectable		 3hgxA-1o0wA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		5 / 9 LEU A  26
GLU A  24
HIS A  -1
ILE A   8
LEU A  30
 None
 1.27A 3hy7B-1o0wA:
undetectable		 3hy7B-1o0wA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		4 / 5 VAL A  97
GLU A 233
LYS A 159
PHE A 153
 None
 1.36A 3rv5C-1o0wA:
0.0
3rv5D-1o0wA:
0.0		 3rv5C-1o0wA:
17.06
3rv5D-1o0wA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		4 / 7 GLU A 114
GLU A 113
GLY A 104
ARG A 119
 None
 1.01A 4fgzA-1o0wA:
undetectable		 4fgzA-1o0wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		4 / 5 GLU A 147
GLU A 143
TYR A 142
GLU A 150
 None
 1.32A 4r87E-1o0wA:
0.0		 4r87E-1o0wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		5 / 12 LEU A 132
LEU A  53
ALA A 135
LEU A  26
ASN A  22
 None
 1.26A 4x1kA-1o0wA:
undetectable
4x1kB-1o0wA:
undetectable		 4x1kA-1o0wA:
18.82
4x1kB-1o0wA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 1o0w RIBONUCLEASE III
(Thermotoga
maritima) 		3 / 3 HIS A  32
ARG A 121
ILE A 124
 None
 0.86A 6fgdA-1o0wA:
undetectable		 6fgdA-1o0wA:
19.91