SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 PHE A  62
ALA A 205
HIS A 174
HIS A 181
ASP A 100
 None
 1.40A 1a4lB-1o0xA:
undetectable		 1a4lB-1o0xA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 PHE A  62
ALA A 205
HIS A 174
HIS A 181
ASP A 100
 None
 1.43A 1a4lD-1o0xA:
undetectable		 1a4lD-1o0xA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 4 LEU A 198
PRO A 208
ILE A 241
LEU A 204
 None
 1.10A 1ya4B-1o0xA:
undetectable		 1ya4B-1o0xA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		6 / 7 TYR A  65
TYR A  68
CYH A  73
HIS A  82
HIS A 181
TRP A 224
 None
 0.47A 1yvmA-1o0xA:
39.3		 1yvmA-1o0xA:
41.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 LEU A 136
ILE A 206
HIS A 181
HIS A 174
ASP A 100
 None
 1.07A 1zz1B-1o0xA:
undetectable
1zz1C-1o0xA:
undetectable		 1zz1B-1o0xA:
21.43
1zz1C-1o0xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 11 LEU A 204
ALA A 248
ILE A 250
ILE A  15
ILE A 241
 None
 1.14A 3ebzA-1o0xA:
undetectable		 3ebzA-1o0xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 5 VAL A  74
GLU A 212
LYS A  92
PHE A  91
 None
 1.30A 3rv5C-1o0xA:
0.7
3rv5D-1o0xA:
1.1		 3rv5C-1o0xA:
16.48
3rv5D-1o0xA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 6 ILE A 168
VAL A 218
SER A 211
ASP A 222
 None
 1.16A 4iaqA-1o0xA:
0.5		 4iaqA-1o0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 7 ILE A  96
THR A 121
VAL A  80
ASP A 214
 None
 1.26A 4iarA-1o0xA:
undetectable		 4iarA-1o0xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 6 ASP A 111
ALA A  21
THR A 240
THR A 252
 None
 1.45A 4w5qA-1o0xA:
0.0		 4w5qA-1o0xA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 6 ASP A 111
ALA A  21
THR A 240
THR A 252
 None
 1.47A 4z4fA-1o0xA:
undetectable		 4z4fA-1o0xA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 5 ASP A 111
ALA A  21
THR A 240
THR A 252
 None
 1.43A 4z4gA-1o0xA:
0.0		 4z4gA-1o0xA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 6 ASP A 111
ALA A  21
THR A 240
THR A 252
 None
 1.45A 4z4iA-1o0xA:
0.0		 4z4iA-1o0xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 7 GLY A 173
HIS A 174
ASP A 111
HIS A  82
 None
 0.80A 5nnwD-1o0xA:
0.5		 5nnwD-1o0xA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 7 GLY A 173
HIS A 174
ASP A 111
HIS A  82
 None
 0.81A 5no9D-1o0xA:
0.5		 5no9D-1o0xA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 1o0x METHIONINE
AMINOPEPTIDASE
(Thermotoga
maritima) 		3 / 3 GLU A 127
LEU A 128
ARG A 233
 None
 0.83A 6d8fA-1o0xA:
undetectable		 6d8fA-1o0xA:
17.00