SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 12 ILE A  20
ARG A 179
LEU A  14
LEU A  85
ILE A  87
 None
SO4  A 409 (-4.1A)
None
None
OCS  A  88 ( 4.0A)
 1.04A 1bsxA-1o1yA:
0.0		 1bsxA-1o1yA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 12 ILE A  20
ARG A 179
LEU A  14
LEU A  85
ILE A  87
 None
SO4  A 409 (-4.1A)
None
None
OCS  A  88 ( 4.0A)
 1.04A 1bsxB-1o1yA:
0.0		 1bsxB-1o1yA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 0.94A 1jlbA-1o1yA:
undetectable		 1jlbA-1o1yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 8 ALA A 167
ILE A  77
ILE A  74
GLY A  90
ILE A  87
 None
None
None
OCS  A  88 ( 3.9A)
OCS  A  88 ( 4.0A)
 1.23A 1sh9A-1o1yA:
undetectable		 1sh9A-1o1yA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.95A 2bfpA-1o1yA:
3.9		 2bfpA-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.97A 2bfpB-1o1yA:
3.7		 2bfpB-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.94A 2bfpC-1o1yA:
undetectable		 2bfpC-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 PHE A 125
LEU A 170
LEU A 217
LEU A 221
 None
 0.95A 2bfpD-1o1yA:
0.9		 2bfpD-1o1yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 12 ILE A  20
ARG A 179
LEU A  14
LEU A  85
ILE A  87
 None
SO4  A 409 (-4.1A)
None
None
OCS  A  88 ( 4.0A)
 1.02A 2h77A-1o1yA:
0.0		 2h77A-1o1yA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WET_B_TRPB650_0
(TRYPTOPHAN
5-HALOGENASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 SER A  91
ILE A   6
HIS A   8
GLN A 171
GLU A  70
 OCS  A  88 ( 2.6A)
None
None
OCS  A  88 ( 4.1A)
None
 1.46A 2wetB-1o1yA:
2.5		 2wetB-1o1yA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 12 LEU A 221
LEU A  85
VAL A 168
ILE A 174
PHE A 125
 None
 1.07A 3datA-1o1yA:
undetectable		 3datA-1o1yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 12 MET A 181
THR A 180
VAL A 134
ALA A 206
ILE A  87
 None
None
None
None
OCS  A  88 ( 4.0A)
 1.12A 3dl9B-1o1yA:
0.0		 3dl9B-1o1yA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 11 LEU A 221
LEU A  85
VAL A 168
ILE A 174
PHE A 125
 None
 1.11A 3frbX-1o1yA:
undetectable		 3frbX-1o1yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 9 LEU A 221
LEU A  85
VAL A 168
ILE A 174
PHE A 125
 None
 1.07A 3freX-1o1yA:
undetectable		 3freX-1o1yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 LEU A 221
LEU A  85
VAL A 168
ILE A 174
PHE A 125
 None
 1.16A 3jw5B-1o1yA:
2.3		 3jw5B-1o1yA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 GLU A 155
SER A 154
ARG A 133
VAL A 116
 None
None
SO4  A 404 ( 4.6A)
None
 1.36A 3jx1A-1o1yA:
undetectable
3jx1B-1o1yA:
undetectable		 3jx1A-1o1yA:
20.70
3jx1B-1o1yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 GLU A 155
SER A 154
ARG A 133
VAL A 116
 None
None
SO4  A 404 ( 4.6A)
None
 1.36A 3rqlA-1o1yA:
undetectable
3rqlB-1o1yA:
undetectable		 3rqlA-1o1yA:
20.70
3rqlB-1o1yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 SER A 219
PHE A 125
LEU A 132
VAL A 134
PHE A 172
 None
 1.28A 3u9fI-1o1yA:
undetectable		 3u9fI-1o1yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 SER A 219
PHE A 125
LEU A 132
VAL A 134
PHE A 172
 None
 1.36A 3u9fR-1o1yA:
undetectable		 3u9fR-1o1yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 GLU A 155
SER A 154
ARG A 133
VAL A 116
 None
None
SO4  A 404 ( 4.6A)
None
 1.38A 4capA-1o1yA:
undetectable
4capB-1o1yA:
undetectable		 4capA-1o1yA:
20.70
4capB-1o1yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 7 GLU A  76
LEU A  73
TYR A  69
LEU A  39
 None
 0.99A 4iomA-1o1yA:
undetectable		 4iomA-1o1yA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 GLU A  76
LEU A  73
TYR A  69
LEU A  39
 None
 0.97A 4jjkA-1o1yA:
undetectable		 4jjkA-1o1yA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 11 GLY A  53
GLY A  54
LEU A  89
HIS A 138
HIS A 173
 OCS  A  88 ( 3.5A)
OCS  A  88 (-4.2A)
OCS  A  88 ( 4.7A)
None
OCS  A  88 ( 3.9A)
 0.72A 4l8fB-1o1yA:
17.3		 4l8fB-1o1yA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 11 GLY A  53
GLY A  54
LEU A  89
HIS A 138
HIS A 173
 OCS  A  88 ( 3.5A)
OCS  A  88 (-4.2A)
OCS  A  88 ( 4.7A)
None
OCS  A  88 ( 3.9A)
 0.73A 4l8fD-1o1yA:
17.4		 4l8fD-1o1yA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 GLY A  86
LEU A  85
LEU A 220
GLU A 175
 None
 0.75A 4po0A-1o1yA:
undetectable		 4po0A-1o1yA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 0.93A 4puoC-1o1yA:
undetectable		 4puoC-1o1yA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 1.00A 4pwdA-1o1yA:
undetectable		 4pwdA-1o1yA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 1.00A 4pwdC-1o1yA:
undetectable		 4pwdC-1o1yA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 LEU A  73
VAL A  49
TYR A  46
LEU A  31
 None
 0.97A 4q0bA-1o1yA:
undetectable		 4q0bA-1o1yA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 8 GLU A 155
SER A 154
ARG A 133
VAL A 116
 None
None
SO4  A 404 ( 4.6A)
None
 1.36A 4v3yA-1o1yA:
undetectable
4v3yB-1o1yA:
undetectable		 4v3yA-1o1yA:
20.70
4v3yB-1o1yA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 9 ALA A 167
LEU A  51
GLY A  86
LEU A  94
LEU A  78
 None
 1.20A 5dqfA-1o1yA:
undetectable		 5dqfA-1o1yA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		3 / 3 LEU A 220
LEU A 170
ARG A 131
 None
None
SO4  A 404 (-3.1A)
 0.53A 5hnzB-1o1yA:
undetectable		 5hnzB-1o1yA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 GLY A  54
TYR A  55
LEU A  89
LEU A  67
GLU A  60
 OCS  A  88 (-4.2A)
None
OCS  A  88 ( 4.7A)
None
None
 1.31A 5hwkA-1o1yA:
undetectable		 5hwkA-1o1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 TYR A  55
LEU A  89
LEU A  67
GLU A  60
TYR A  64
 None
OCS  A  88 ( 4.7A)
None
None
None
 1.33A 5hwkA-1o1yA:
undetectable		 5hwkA-1o1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 GLY A  54
TYR A  55
LEU A  89
LEU A  67
GLU A  60
 OCS  A  88 (-4.2A)
None
OCS  A  88 ( 4.7A)
None
None
 1.31A 5hwkB-1o1yA:
0.0		 5hwkB-1o1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		5 / 10 TYR A  55
LEU A  89
LEU A  67
GLU A  60
TYR A  64
 None
OCS  A  88 ( 4.7A)
None
None
None
 1.33A 5hwkB-1o1yA:
0.0		 5hwkB-1o1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1o1y CONSERVED
HYPOTHETICAL PROTEIN
TM1158
(Thermotoga
maritima) 		4 / 7 ASP A 140
GLN A  92
LYS A  89
TYR A  55
 SO4  A 402 (-3.3A)
SO4  A 402 ( 3.9A)
OCS  A  88 ( 2.8A)
None
 1.44A 6g31G-1o1yA:
undetectable		 6g31G-1o1yA:
18.34