SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 10 THR A 368
ALA A 247
LEU A 261
VAL A 263
ILE A 244
 None
 1.31A 1claA-1o20A:
undetectable		 1claA-1o20A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 11 GLY A 204
GLY A 206
ILE A 120
TYR A 121
LEU A 151
 None
 1.23A 1p91A-1o20A:
3.8		 1p91A-1o20A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 LYS A  32
ILE A  86
THR A 132
 None
 0.79A 1rx3A-1o20A:
2.2		 1rx3A-1o20A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 TRP A  15
LYS A  26
PRO A 113
 None
 1.41A 2dqyB-1o20A:
undetectable		 2dqyB-1o20A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 7 THR A 131
ALA A 150
ASN A 154
PHE A 177
 None
 1.19A 2hzqA-1o20A:
undetectable		 2hzqA-1o20A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
 None
 1.14A 3a50A-1o20A:
undetectable		 3a50A-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 11 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
 None
 1.10A 3a50B-1o20A:
undetectable		 3a50B-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 11 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
 None
 1.12A 3a50C-1o20A:
undetectable		 3a50C-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
 None
 1.18A 3a51D-1o20A:
undetectable		 3a51D-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 GLY A 288
ILE A 275
VAL A 276
 None
 0.48A 3nv6A-1o20A:
undetectable		 3nv6A-1o20A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 GLY A 223
GLU A 221
GLY A 393
ALA A 359
PHE A 376
 None
 1.10A 3qowA-1o20A:
undetectable		 3qowA-1o20A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 4 SER A 339
GLY A 373
GLU A 130
 None
 0.63A 3raeA-1o20A:
undetectable
3raeC-1o20A:
1.8		 3raeA-1o20A:
23.41
3raeC-1o20A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 8 GLU A 172
GLU A 163
LYS A  36
ARG A  40
 None
 0.97A 4bqfB-1o20A:
2.0		 4bqfB-1o20A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 LYS A  32
ILE A  86
THR A 132
 None
 0.83A 4gh8A-1o20A:
undetectable		 4gh8A-1o20A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 5 LYS A   7
LEU A   4
GLU A   3
LEU A 185
 None
 1.27A 4k4yA-1o20A:
0.0		 4k4yA-1o20A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 4 LYS A   7
LEU A   4
GLU A   3
LEU A 185
 None
 1.28A 4k4yE-1o20A:
0.0		 4k4yE-1o20A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		4 / 5 LYS A   7
LEU A   4
GLU A   3
LEU A 185
 None
 1.27A 4k4yI-1o20A:
0.0		 4k4yI-1o20A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 9 GLY A 337
ALA A 359
ASP A 358
ILE A 384
THR A 368
 None
 1.18A 4njtD-1o20A:
undetectable		 4njtD-1o20A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 THR A 371
THR A 254
CYH A 227
THR A 222
THR A 386
 None
 1.22A 5d0xH-1o20A:
undetectable
5d0xI-1o20A:
undetectable		 5d0xH-1o20A:
20.20
5d0xI-1o20A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 11 LEU A 397
VAL A  85
ILE A  30
ALA A  21
ILE A 170
 None
 1.17A 5gpgA-1o20A:
undetectable		 5gpgA-1o20A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 LYS A  10
LEU A  18
ILE A 142
 None
 0.72A 5kc0A-1o20A:
undetectable		 5kc0A-1o20A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 LYS A  10
LEU A  18
ILE A 142
 None
 0.70A 5kc4A-1o20A:
undetectable		 5kc4A-1o20A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		3 / 3 PRO A 171
SER A 173
SER A 174
 None
 0.58A 6bpyA-1o20A:
2.1		 6bpyA-1o20A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A 243
ILE A 244
ILE A 318
PHE A 271
ILE A 357
 None
 1.17A 6mkeA-1o20A:
undetectable
6mkeD-1o20A:
undetectable		 6mkeA-1o20A:
11.24
6mkeD-1o20A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Thermotoga
maritima) 		5 / 12 VAL A 243
ILE A 244
ILE A 318
PHE A 271
ILE A 357
 None
 1.17A 6mkeB-1o20A:
undetectable
6mkeC-1o20A:
undetectable		 6mkeB-1o20A:
11.24
6mkeC-1o20A:
11.24