SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 5 GLY A 259
LEU A 262
THR A 263
VAL A 277
 None
 0.76A 1ekjF-1o2dA:
undetectable
1ekjG-1o2dA:
2.1		 1ekjF-1o2dA:
22.96
1ekjG-1o2dA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 GLU A 117
TYR A 120
PHE A  72
 None
 0.82A 1eqbB-1o2dA:
3.2		 1eqbB-1o2dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 GLU A 117
TYR A 120
PHE A  72
 None
 0.82A 1eqbA-1o2dA:
4.1		 1eqbA-1o2dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 GLU A 117
TYR A 120
PHE A  72
 None
 0.82A 1eqbD-1o2dA:
4.0		 1eqbD-1o2dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 GLU A 117
TYR A 120
PHE A  72
 None
 0.83A 1eqbC-1o2dA:
4.5		 1eqbC-1o2dA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		6 / 12 GLY A 139
ALA A 190
ASP A 189
GLY A 244
ILE A 217
ILE A 218
 None
None
FE  A 900 ( 2.5A)
None
None
None
 1.35A 1hshA-1o2dA:
undetectable		 1hshA-1o2dA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 193
ALA A 190
GLY A 141
ARG A 233
LEU A 222
 FE  A 900 ( 3.4A)
None
None
None
None
 1.27A 1mj2A-1o2dA:
undetectable
1mj2B-1o2dA:
undetectable		 1mj2A-1o2dA:
15.96
1mj2B-1o2dA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 THR A 274
LEU A 278
VAL A 281
 None
 0.63A 1mz9E-1o2dA:
undetectable		 1mz9E-1o2dA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A 187
ALA A 239
SER A 240
GLY A 275
SER A 192
 None
 1.30A 1nbiD-1o2dA:
undetectable		 1nbiD-1o2dA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 11 GLY A 244
HIS A 193
GLY A  96
ASP A 100
VAL A 144
 None
FE  A 900 ( 3.4A)
NAP  A1800 (-3.3A)
NAP  A1800 (-2.8A)
None
 1.10A 1pg2A-1o2dA:
undetectable		 1pg2A-1o2dA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A 141
HIS A 193
GLY A  96
ASP A 100
VAL A 144
 None
FE  A 900 ( 3.4A)
NAP  A1800 (-3.3A)
NAP  A1800 (-2.8A)
None
 1.17A 1qu2A-1o2dA:
undetectable		 1qu2A-1o2dA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.76A 1rxcB-1o2dA:
undetectable		 1rxcB-1o2dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.76A 1rxcE-1o2dA:
undetectable		 1rxcE-1o2dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.84A 1rxcI-1o2dA:
undetectable		 1rxcI-1o2dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.73A 1rxcK-1o2dA:
undetectable		 1rxcK-1o2dA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 HIS A 256
GLY A 251
THR A 274
ILE A 247
 FE  A 900 (-4.4A)
None
None
None
 0.96A 2a8tB-1o2dA:
0.0		 2a8tB-1o2dA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 HIS A 270
THR A 263
ILE A 149
ASN A  69
 FE  A 900 ( 3.4A)
None
NAP  A1800 (-3.9A)
NAP  A1800 (-4.2A)
 0.90A 2a8tB-1o2dA:
0.0		 2a8tB-1o2dA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 THR A 145
GLY A 141
SER A 142
GLY A  96
ILE A 218
 NAP  A1800 (-3.2A)
None
NAP  A1800 (-3.3A)
NAP  A1800 (-3.3A)
None
 1.15A 2b25B-1o2dA:
undetectable		 2b25B-1o2dA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A  96
GLY A 187
ALA A 190
HIS A 193
ALA A 243
 NAP  A1800 (-3.3A)
None
None
FE  A 900 ( 3.4A)
None
 0.98A 2bm9F-1o2dA:
2.7		 2bm9F-1o2dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A 275
LEU A 278
GLY A 197
ALA A 194
ALA A 214
 None
 1.05A 2bm9F-1o2dA:
2.7		 2bm9F-1o2dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A 275
LEU A 278
GLY A 197
ALA A 194
ASP A 189
 None
None
None
None
FE  A 900 ( 2.5A)
 0.95A 2bm9F-1o2dA:
2.7		 2bm9F-1o2dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 6 ARG A 333
ASP A 152
THR A 151
ASP A  73
 None
 1.14A 2okcB-1o2dA:
undetectable		 2okcB-1o2dA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
GLY A 259
HIS A 256
GLU A 196
ASP A 189
 FE  A 900 ( 3.4A)
None
FE  A 900 (-4.4A)
None
FE  A 900 ( 2.5A)
 1.22A 2pgfA-1o2dA:
undetectable		 2pgfA-1o2dA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 ILE A 149
ASP A 100
GLY A  96
SER A 185
ASP A 189
 NAP  A1800 (-3.9A)
NAP  A1800 (-2.8A)
NAP  A1800 (-3.3A)
None
FE  A 900 ( 2.5A)
 1.25A 2pgfA-1o2dA:
undetectable		 2pgfA-1o2dA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 ILE A  23
GLY A  21
LEU A  52
LEU A  53
 None
 0.89A 2vctC-1o2dA:
0.6		 2vctC-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 313
THR A 186
ASP A 189
SER A  97
ASN A  69
 None
NAP  A1800 (-4.7A)
FE  A 900 ( 2.5A)
NAP  A1800 (-2.6A)
NAP  A1800 (-4.2A)
 1.23A 2y00B-1o2dA:
undetectable		 2y00B-1o2dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A 313
THR A 186
ASP A 189
SER A  97
ASN A  69
 None
NAP  A1800 (-4.7A)
FE  A 900 ( 2.5A)
NAP  A1800 (-2.6A)
NAP  A1800 (-4.2A)
 1.21A 2y01B-1o2dA:
undetectable		 2y01B-1o2dA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 ASP A  64
PHE A  63
LEU A  32
 None
 0.64A 2zi9A-1o2dA:
undetectable		 2zi9A-1o2dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.09A 2zj0D-1o2dA:
2.6		 2zj0D-1o2dA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 TYR A 174
VAL A  91
LEU A  93
VAL A 132
 None
 0.60A 2zujA-1o2dA:
undetectable		 2zujA-1o2dA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 9 ARG A 350
ALA A 356
VAL A 317
ILE A 268
GLY A 259
 None
 1.08A 3el4B-1o2dA:
undetectable		 3el4B-1o2dA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 4 PRO A 135
THR A 137
GLY A 271
THR A 274
 None
NAP  A1800 (-2.9A)
None
None
 1.08A 3ib1A-1o2dA:
0.3		 3ib1A-1o2dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 6 HIS A 256
HIS A 193
HIS A 270
ASP A 100
 FE  A 900 (-4.4A)
FE  A 900 ( 3.4A)
FE  A 900 ( 3.4A)
NAP  A1800 (-2.8A)
 0.81A 3nvcA-1o2dA:
0.0		 3nvcA-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 ASP A 180
GLU A 227
GLY A 228
 None
 0.69A 3w9tA-1o2dA:
undetectable		 3w9tA-1o2dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A  32
ALA A  31
LEU A  52
LEU A  53
GLY A  21
 None
 1.12A 4dm8B-1o2dA:
undetectable		 4dm8B-1o2dA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.72A 4e1vA-1o2dA:
undetectable		 4e1vA-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.74A 4e1vC-1o2dA:
undetectable		 4e1vC-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.74A 4e1vD-1o2dA:
undetectable		 4e1vD-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.76A 4e1vE-1o2dA:
undetectable		 4e1vE-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.83A 4e1vG-1o2dA:
undetectable		 4e1vG-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 THR A 252
GLY A 197
ILE A 247
VAL A 246
 None
 0.78A 4e1vH-1o2dA:
undetectable		 4e1vH-1o2dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A  49
VAL A  91
ALA A  31
GLU A  55
THR A  56
 None
 1.24A 4fiaA-1o2dA:
undetectable		 4fiaA-1o2dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A  49
VAL A  91
ALA A  31
GLU A  55
THR A  56
 None
 1.24A 4fiaA-1o2dA:
undetectable		 4fiaA-1o2dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 10 PHE A 344
THR A 340
THR A 274
ILE A 352
VAL A 277
 None
 1.21A 4jx1B-1o2dA:
undetectable		 4jx1B-1o2dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 ARG A  81
GLU A  61
PHE A  87
 None
 0.78A 4kszA-1o2dA:
0.0		 4kszA-1o2dA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 THR A 253
HIS A 219
LEU A 304
 None
 0.87A 5axdC-1o2dA:
2.3		 5axdC-1o2dA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 GLY A 187
GLY A 139
ILE A 226
LEU A 222
ALA A 243
 None
 0.89A 5bw4B-1o2dA:
undetectable		 5bw4B-1o2dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 5hm8A-1o2dA:
2.6		 5hm8A-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 5hm8B-1o2dA:
2.6		 5hm8B-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 5hm8C-1o2dA:
2.6		 5hm8C-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 5hm8D-1o2dA:
2.5		 5hm8D-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.11A 5hm8E-1o2dA:
2.3		 5hm8E-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 5hm8F-1o2dA:
undetectable		 5hm8F-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.11A 5hm8G-1o2dA:
undetectable		 5hm8G-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 5hm8H-1o2dA:
2.6		 5hm8H-1o2dA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 193
ASP A 189
HIS A 270
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.68A 5oexA-1o2dA:
0.0		 5oexA-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 270
ASP A 189
HIS A 193
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.44A 5oexA-1o2dA:
0.0		 5oexA-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 193
ASP A 189
HIS A 270
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.73A 5oexB-1o2dA:
0.0		 5oexB-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 270
ASP A 189
HIS A 193
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.34A 5oexB-1o2dA:
0.0		 5oexB-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 193
ASP A 189
HIS A 270
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.70A 5oexC-1o2dA:
undetectable		 5oexC-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 270
ASP A 189
HIS A 193
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.31A 5oexC-1o2dA:
undetectable		 5oexC-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 193
ASP A 189
HIS A 270
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.70A 5oexD-1o2dA:
undetectable		 5oexD-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 HIS A 270
ASP A 189
HIS A 193
 FE  A 900 ( 3.4A)
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
 0.33A 5oexD-1o2dA:
undetectable		 5oexD-1o2dA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 PRO A 172
THR A 136
THR A 175
TYR A 176
 None
NAP  A1800 (-4.0A)
None
None
 1.32A 5x2sI-1o2dA:
undetectable
5x2sJ-1o2dA:
undetectable
5x2sK-1o2dA:
undetectable		 5x2sI-1o2dA:
16.67
5x2sJ-1o2dA:
17.82
5x2sK-1o2dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 THR A 274
GLU A 196
HIS A 336
 None
 0.72A 5xioA-1o2dA:
3.6		 5xioA-1o2dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A  49
GLU A 133
VAL A  91
PHE A 237
THR A 186
 None
None
None
None
NAP  A1800 (-4.7A)
 1.44A 5xiqB-1o2dA:
undetectable		 5xiqB-1o2dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 THR A 274
GLU A 196
HIS A 336
 None
 0.75A 5xiqB-1o2dA:
undetectable		 5xiqB-1o2dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		3 / 3 THR A 274
GLU A 196
HIS A 336
 None
 0.81A 5xiqD-1o2dA:
undetectable		 5xiqD-1o2dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 LEU A  32
MET A 163
VAL A  90
THR A  35
GLY A  36
 None
None
None
None
NAP  A1800 (-3.6A)
 1.45A 6brdA-1o2dA:
undetectable		 6brdA-1o2dA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		4 / 8 LEU A  49
LEU A  17
GLY A  95
TYR A 174
 None
None
NAP  A1800 (-3.2A)
None
 0.94A 6ce2A-1o2dA:
undetectable		 6ce2A-1o2dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.11A 6f3mA-1o2dA:
2.4		 6f3mA-1o2dA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 6f3mB-1o2dA:
2.0		 6f3mB-1o2dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.11A 6f3mC-1o2dA:
2.5		 6f3mC-1o2dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_1
(-)		 1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING
(Thermotoga
maritima) 		5 / 12 HIS A 270
THR A 263
ASP A 189
HIS A 193
GLY A 259
 FE  A 900 ( 3.4A)
None
FE  A 900 ( 2.5A)
FE  A 900 ( 3.4A)
None
 1.12A 6f3mD-1o2dA:
2.5		 6f3mD-1o2dA:
21.31