SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.04A 1rjdA-1o3tA:
undetectable		 1rjdA-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.02A 1rjdB-1o3tA:
undetectable		 1rjdB-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.05A 1rjdC-1o3tA:
undetectable		 1rjdC-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 7 VAL A 139
ILE A 186
VAL A 176
GLY A 141
THR A 140
 None
 0.99A 2xrzB-1o3tA:
undetectable		 2xrzB-1o3tA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		3 / 3 SER A  46
ALA A  48
VAL A  49
 None
None
CMP  A 762 (-4.5A)
 0.59A 4x20C-1o3tA:
undetectable		 4x20C-1o3tA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		3 / 5 GLY A  74
GLY A  79
GLU A  78
 CMP  A 762 ( 4.9A)
None
None
 0.51A 4z2eA-1o3tA:
undetectable
4z2eD-1o3tA:
undetectable		 4z2eA-1o3tA:
17.25
4z2eD-1o3tA:
20.51