SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 1rxcB-1o4sA:
undetectable		 1rxcB-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.93A 1rxcC-1o4sA:
undetectable		 1rxcC-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 1rxcD-1o4sA:
undetectable		 1rxcD-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.86A 1rxcE-1o4sA:
undetectable		 1rxcE-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 1rxcF-1o4sA:
undetectable		 1rxcF-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.88A 1rxcI-1o4sA:
undetectable		 1rxcI-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.90A 1rxcK-1o4sA:
undetectable		 1rxcK-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.86A 1rxcL-1o4sA:
undetectable		 1rxcL-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 LEU A 301
PHE A 319
LEU A  17
SER A 355
 None
 0.98A 1wrlC-1o4sA:
undetectable
1wrlD-1o4sA:
undetectable		 1wrlC-1o4sA:
15.73
1wrlD-1o4sA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 TYR A  62
THR A  63
PRO A  65
VAL A  94
LEU A  71
 None
 1.44A 1z9hA-1o4sA:
0.5		 1z9hA-1o4sA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 TYR A  62
THR A  63
PRO A  65
VAL A  94
LEU A  71
 None
 1.44A 1z9hB-1o4sA:
0.4		 1z9hB-1o4sA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 TYR A  62
THR A  63
PRO A  65
VAL A  94
LEU A  71
 None
 1.45A 1z9hC-1o4sA:
0.4		 1z9hC-1o4sA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 TYR A 245
TYR A 228
ILE A  87
ILE A  75
 None
 1.25A 2dcfA-1o4sA:
0.0		 2dcfA-1o4sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 LEU A 340
LEU A 363
PHE A 319
 None
 0.64A 2pgrA-1o4sA:
undetectable		 2pgrA-1o4sA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASP A 205
ILE A 247
ILE A  87
ARG A  82
ALA A 278
 None
 1.15A 2qmjA-1o4sA:
undetectable		 2qmjA-1o4sA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 LEU A 367
LEU A 363
ILE A 370
ARG A 369
 None
 0.98A 2rlfC-1o4sA:
undetectable
2rlfD-1o4sA:
undetectable		 2rlfC-1o4sA:
8.06
2rlfD-1o4sA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLY A  97
GLY A 231
GLY A 244
 PLP  A1234 (-3.4A)
None
None
 0.43A 3bogC-1o4sA:
undetectable		 3bogC-1o4sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLY A  97
GLY A 231
GLY A 244
 PLP  A1234 (-3.4A)
None
None
 0.39A 3bogD-1o4sA:
undetectable		 3bogD-1o4sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 8 TYR A 316
LEU A 354
GLY A 343
ALA A 345
THR A  14
 None
 1.45A 3jusB-1o4sA:
undetectable		 3jusB-1o4sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 9 TYR A 316
LEU A 354
GLY A 343
ALA A 345
THR A  14
 None
 1.45A 3jusB-1o4sA:
undetectable		 3jusB-1o4sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.88A 3kvvA-1o4sA:
undetectable		 3kvvA-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.88A 3kvvB-1o4sA:
undetectable		 3kvvB-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.87A 3kvvC-1o4sA:
undetectable		 3kvvC-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.90A 3kvvD-1o4sA:
undetectable		 3kvvD-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.87A 3kvvE-1o4sA:
undetectable		 3kvvE-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.87A 3kvvF-1o4sA:
undetectable		 3kvvF-1o4sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.90A 4e1vA-1o4sA:
undetectable		 4e1vA-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 4e1vB-1o4sA:
undetectable		 4e1vB-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 4e1vC-1o4sA:
undetectable		 4e1vC-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 4e1vD-1o4sA:
undetectable		 4e1vD-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.86A 4e1vE-1o4sA:
undetectable		 4e1vE-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.89A 4e1vF-1o4sA:
undetectable		 4e1vF-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.88A 4e1vG-1o4sA:
undetectable		 4e1vG-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 244
MET A 238
ILE A 267
VAL A  94
 None
 0.86A 4e1vH-1o4sA:
undetectable		 4e1vH-1o4sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 LEU A 184
LEU A 187
LEU A 190
ALA A 191
ALA A 165
 None
 0.69A 4fn9A-1o4sA:
undetectable		 4fn9A-1o4sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 PRO A  89
VAL A  92
TYR A 245
GLY A  80
GLY A  74
 None
 0.88A 4mmdB-1o4sA:
0.0		 4mmdB-1o4sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PRO A  89
ARG A  72
GLU A  73
 None
 0.67A 5j6hA-1o4sA:
undetectable		 5j6hA-1o4sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		5 / 12 PHE A 106
TYR A 126
LEU A 246
ALA A 105
LEU A 109
 None
 1.16A 5ljcA-1o4sA:
undetectable		 5ljcA-1o4sA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 7 LEU A 301
PHE A 308
LEU A 317
PHE A 356
 None
 0.92A 5z84C-1o4sA:
undetectable
5z84J-1o4sA:
undetectable		 5z84C-1o4sA:
21.52
5z84J-1o4sA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1o4s ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 5 ILE A 226
SER A 248
ALA A 165
LEU A 187
 None
 1.01A 6dwnA-1o4sA:
0.0		 6dwnA-1o4sA:
11.31