SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 PHE A 114
TYR A  70
GLY A  59
VAL A  29
 None
OXL  A 400 (-4.7A)
None
None
 0.79A 2a1oA-1o4tA:
undetectable		 2a1oA-1o4tA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 9 LEU A  46
HIS A  63
GLU A  68
HIS A 102
ALA A 116
 None
MN  A 300 ( 3.2A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.4A)
OXL  A 400 ( 4.5A)
 1.33A 2bnnA-1o4tA:
12.2
2bnnB-1o4tA:
11.9		 2bnnA-1o4tA:
21.50
2bnnB-1o4tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 8 LEU A  46
HIS A  63
GLU A  68
HIS A  61
ALA A 116
 None
MN  A 300 ( 3.2A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.3A)
OXL  A 400 ( 4.5A)
 1.50A 2bnnA-1o4tA:
12.2
2bnnB-1o4tA:
11.9		 2bnnA-1o4tA:
21.50
2bnnB-1o4tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 8 LEU A  46
HIS A  63
GLU A  68
HIS A 102
ALA A 116
 None
MN  A 300 ( 3.2A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.4A)
OXL  A 400 ( 4.5A)
 1.34A 2bnnA-1o4tA:
12.2
2bnnB-1o4tA:
11.9		 2bnnA-1o4tA:
21.50
2bnnB-1o4tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 8 HIS A  61
HIS A  63
HIS A 102
VAL A  58
 MN  A 300 ( 3.3A)
MN  A 300 ( 3.2A)
MN  A 300 ( 3.4A)
None
 0.83A 2gehA-1o4tA:
undetectable		 2gehA-1o4tA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 4 HIS A 102
GLU A  68
HIS A  63
HIS A  61
 MN  A 300 ( 3.4A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.2A)
MN  A 300 ( 3.3A)
 1.18A 2hu6A-1o4tA:
undetectable		 2hu6A-1o4tA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 7 LEU A  52
PHE A  79
PHE A 114
GLU A  68
 None
None
None
MN  A 300 ( 2.7A)
 0.94A 2opxA-1o4tA:
undetectable		 2opxA-1o4tA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 4 HIS A 102
GLU A  68
HIS A  63
HIS A  61
 MN  A 300 ( 3.4A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.2A)
MN  A 300 ( 3.3A)
 1.15A 2ozrC-1o4tA:
undetectable		 2ozrC-1o4tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 4 HIS A 102
GLU A  68
HIS A  63
HIS A  61
 MN  A 300 ( 3.4A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.2A)
MN  A 300 ( 3.3A)
 1.15A 2ozrD-1o4tA:
undetectable		 2ozrD-1o4tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 4 HIS A 102
GLU A  68
HIS A  63
HIS A  61
 MN  A 300 ( 3.4A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.2A)
MN  A 300 ( 3.3A)
 1.20A 3lilA-1o4tA:
undetectable		 3lilA-1o4tA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		3 / 3 SER A  57
GLY A  25
SER A 103
 None
 0.65A 3loqA-1o4tA:
undetectable		 3loqA-1o4tA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 4 HIS A 102
GLU A  68
HIS A  63
HIS A  61
 MN  A 300 ( 3.4A)
MN  A 300 ( 2.7A)
MN  A 300 ( 3.2A)
MN  A 300 ( 3.3A)
 1.19A 5n5jA-1o4tA:
undetectable		 5n5jA-1o4tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		5 / 8 HIS A  63
HIS A 102
HIS A  61
LEU A  46
ALA A 116
 MN  A 300 ( 3.2A)
MN  A 300 ( 3.4A)
MN  A 300 ( 3.3A)
None
OXL  A 400 ( 4.5A)
 1.45A 5tt3H-1o4tA:
undetectable		 5tt3H-1o4tA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		3 / 3 HIS A  61
HIS A 102
HIS A  63
 MN  A 300 ( 3.3A)
MN  A 300 ( 3.4A)
MN  A 300 ( 3.2A)
 0.58A 5zrdA-1o4tA:
undetectable		 5zrdA-1o4tA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1o4t PUTATIVE OXALATE
DECARBOXYLASE
(Thermotoga
maritima) 		4 / 6 LEU A  52
HIS A  61
HIS A 102
GLU A  68
 None
MN  A 300 ( 3.3A)
MN  A 300 ( 3.4A)
MN  A 300 ( 2.7A)
 1.10A 6pahA-1o4tA:
undetectable		 6pahA-1o4tA:
19.09