SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 6 SER A 234
ASP A 208
SER A 254
VAL A 252
 None
 0.96A 2hdnI-1o4uA:
undetectable
2hdnJ-1o4uA:
undetectable
2hdnL-1o4uA:
2.6		 2hdnI-1o4uA:
8.74
2hdnJ-1o4uA:
23.56
2hdnL-1o4uA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 7 ASP A 203
VAL A 174
ARG A 175
ILE A 178
 None
 0.95A 2yfbA-1o4uA:
0.0		 2yfbA-1o4uA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 7 MET A   1
LEU A   5
ARG A  51
GLY A  46
 None
 1.04A 3hcnA-1o4uA:
2.2		 3hcnA-1o4uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 12 ILE A 218
VAL A 229
ILE A 184
VAL A 186
VAL A 188
 None
 1.18A 3iw1A-1o4uA:
undetectable		 3iw1A-1o4uA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		3 / 3 LEU A  59
GLU A  81
SER A  61
 None
 0.71A 4ccqA-1o4uA:
3.3		 4ccqA-1o4uA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 8 THR A  30
LEU A  87
ILE A 271
LEU A  88
 None
 0.71A 5g48A-1o4uA:
undetectable		 5g48A-1o4uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		3 / 3 ASP A 224
ASN A 226
PHE A 247
 None
 0.88A 5jglB-1o4uA:
undetectable		 5jglB-1o4uA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1o4u TYPE II QUINOLIC
ACID
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 7 LEU A  94
GLU A  55
ILE A 136
VAL A  49
 None
 1.15A 5jh7C-1o4uA:
undetectable		 5jh7C-1o4uA:
20.38