SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
4 / 6 LYS A 154
GLN A 156
LEU A 158
GLU A 159
None
0.92A 3h5gA-1o4vA:
undetectable
3h5gC-1o4vA:
undetectable
3h5gA-1o4vA:
9.29
3h5gC-1o4vA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
5 / 12 ILE A  35
GLY A   9
ALA A  62
ASP A  13
ALA A  38
None
SO4  A 200 ( 3.9A)
None
None
SO4  A 200 (-4.7A)
1.04A 3jb1A-1o4vA:
0.0
3jb1A-1o4vA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
3 / 3 GLY A 122
ILE A  60
VAL A  59
None
0.49A 3nv6A-1o4vA:
undetectable
3nv6A-1o4vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
5 / 12 LEU A  24
VAL A  85
ILE A 128
LEU A 124
VAL A 113
None
1.12A 3w68B-1o4vA:
1.4
3w68B-1o4vA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
5 / 12 GLY A 122
ALA A  20
ILE A  33
GLY A   5
ILE A  60
None
1.05A 4njvD-1o4vA:
undetectable
4njvD-1o4vA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
5 / 9 ALA A 125
ILE A 136
GLY A 130
ILE A 131
ILE A  57
None
1.17A 4nptA-1o4vA:
0.0
4nptA-1o4vA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
5 / 9 ARG A 146
LEU A  24
ILE A  29
GLY A  28
ALA A 126
None
0.87A 5o96A-1o4vA:
4.3
5o96B-1o4vA:
4.6
5o96A-1o4vA:
20.73
5o96B-1o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)
1o4v PHOSPHORIBOSYLAMINOI
MIDAZOLE MUTASE PURE

(Thermotoga
maritima)
3 / 3 ARG A 146
LYS A 119
ARG A 149
None
1.11A 6az3C-1o4vA:
0.0
6az3L-1o4vA:
0.0
6az3M-1o4vA:
undetectable
6az3C-1o4vA:
20.28
6az3L-1o4vA:
18.02
6az3M-1o4vA:
17.71