SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ALA A 193
VAL A 165
TRP A 240
 None
 1.01A 1gmkA-1o4zA:
undetectable
1gmkB-1o4zA:
undetectable		 1gmkA-1o4zA:
5.21
1gmkB-1o4zA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILP_C_ACAC7_1
(PROTEIN
(INTERLEUKIN-8
PRECURSOR)
PROTEIN
(INTERLEUKIN-8
RECEPTOR))		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 5 LYS A 228
PRO A 227
HIS A 215
ASP A 224
 None
 1.49A 1ilpA-1o4zA:
0.0
1ilpC-1o4zA:
undetectable		 1ilpA-1o4zA:
11.90
1ilpC-1o4zA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ARG A 246
ARG A 346
ILE A 187
 NA  A1007 (-4.1A)
None
None
 0.77A 1uobA-1o4zA:
1.5		 1uobA-1o4zA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 TRP A 233
GLU A 189
TYR A 191
 None
EPE  A2002 (-3.0A)
None
 1.23A 2a3aA-1o4zA:
undetectable		 2a3aA-1o4zA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ASP A 103
ILE A 147
LEU A 129
TYR A  86
 None
 1.05A 2ya7A-1o4zA:
1.8		 2ya7A-1o4zA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ASP A 103
ILE A 147
LEU A 129
TYR A  86
 None
 1.06A 2ya7B-1o4zA:
1.8		 2ya7B-1o4zA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ASP A 103
ILE A 147
LEU A 129
TYR A  86
 None
 1.06A 2ya7D-1o4zA:
1.5		 2ya7D-1o4zA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 4 GLY A 127
GLU A  85
ASP A  82
ASP A 126
 NA  A1004 (-3.9A)
NA  A1004 (-4.2A)
None
None
 1.16A 3mb5A-1o4zA:
undetectable		 3mb5A-1o4zA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		4 / 6 ILE A 347
ILE A 261
GLY A 248
VAL A 342
 None
 0.95A 3n3iA-1o4zA:
undetectable		 3n3iA-1o4zA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		5 / 12 THR A 169
GLY A 192
ASP A 194
SER A 207
GLU A 197
 None
 1.37A 3tkaA-1o4zA:
undetectable		 3tkaA-1o4zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 TRP A 109
TRP A 117
THR A 115
 None
 1.26A 4bboB-1o4zA:
undetectable		 4bboB-1o4zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		5 / 12 MET A 144
THR A 115
ASN A 306
GLU A 189
ASP A 173
 None
None
None
EPE  A2002 (-3.0A)
EPE  A2002 (-3.5A)
 1.40A 4dvoA-1o4zA:
undetectable		 4dvoA-1o4zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		6 / 12 GLY A 248
ILE A  63
ILE A 347
VAL A 342
VAL A 153
ILE A  80
 None
 1.49A 4q5mA-1o4zA:
undetectable		 4q5mA-1o4zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ASP A 102
ASP A 103
ASN A  92
 None
 0.81A 4q5mA-1o4zA:
undetectable		 4q5mA-1o4zA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ARG A 162
ASP A 343
TRP A 344
 None
NA  A1004 (-3.2A)
None
 0.35A 4xdqA-1o4zA:
19.0		 4xdqA-1o4zA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 ARG A 246
TYR A 158
GLU A 160
 NA  A1007 (-4.1A)
None
None
 0.67A 4zzbE-1o4zA:
undetectable		 4zzbE-1o4zA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		5 / 11 HIS A 211
HIS A 215
VAL A 216
ASP A 276
PRO A 277
 None
 0.89A 5z0fA-1o4zA:
undetectable
5z0fB-1o4zA:
0.0		 5z0fA-1o4zA:
12.14
5z0fB-1o4zA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		5 / 11 HIS A 211
HIS A 215
VAL A 216
SER A 213
ASP A 276
 None
 1.30A 5z0fA-1o4zA:
undetectable
5z0fB-1o4zA:
0.0		 5z0fA-1o4zA:
12.14
5z0fB-1o4zA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1o4z BETA-AGARASE B
(Zobellia
galactanivorans) 		3 / 3 TYR A 225
ASP A 224
GLN A 226
 None
 0.88A 6g1pA-1o4zA:
undetectable		 6g1pA-1o4zA:
21.24