SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 SER A  22
GLY A  39
THR A  36
ILE A  41
 None
 0.89A 1gtnD-1o54A:
0.5
1gtnE-1o54A:
0.5		 1gtnD-1o54A:
13.78
1gtnE-1o54A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A 108
SER A 111
GLU A 132
ASP A 160
 None
CL  A 266 ( 4.4A)
None
None
 0.75A 1jg4A-1o54A:
13.4		 1jg4A-1o54A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ASP A  20
LYS A  62
ARG A  56
 None
 0.89A 1ra8A-1o54A:
0.0		 1ra8A-1o54A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 108
GLY A 110
MET A 114
ASP A 160
ILE A 161
 None
 0.88A 2b25A-1o54A:
24.4		 2b25A-1o54A:
28.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLY A 108
GLU A 132
ASP A 176
 None
 0.39A 2b25B-1o54A:
25.6		 2b25B-1o54A:
28.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A  83
GLY A 108
GLY A 110
ALA A 113
VAL A 177
 CL  A 266 ( 4.7A)
None
None
CL  A 266 (-3.6A)
None
 0.44A 2yvlA-1o54A:
27.7		 2yvlA-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A  83
GLY A 108
GLY A 110
SER A 111
VAL A 177
 CL  A 266 ( 4.7A)
None
None
CL  A 266 ( 4.4A)
None
 0.94A 2yvlA-1o54A:
27.7		 2yvlA-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_A_SAMA601_1
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 GLU A 132
ASP A 160
ASP A 176
TYR A 183
 None
 0.68A 2yvlA-1o54A:
27.7		 2yvlA-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 ILE A  83
GLY A 108
GLY A 110
ALA A 113
ASP A 176
VAL A 177
 CL  A 266 ( 4.7A)
None
None
CL  A 266 (-3.6A)
None
None
 0.39A 2yvlB-1o54A:
27.7		 2yvlB-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLU A 132
ASP A 160
TYR A 183
 None
 0.77A 2yvlB-1o54A:
27.7		 2yvlB-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A  83
GLY A 110
ALA A 113
ASP A 176
VAL A 177
 CL  A 266 ( 4.7A)
None
CL  A 266 (-3.6A)
None
None
 0.35A 2yvlC-1o54A:
23.8		 2yvlC-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ILE A  83
GLY A 110
SER A 111
ASP A 176
VAL A 177
 CL  A 266 ( 4.7A)
None
CL  A 266 ( 4.4A)
None
None
 0.89A 2yvlC-1o54A:
23.8		 2yvlC-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 GLY A 108
GLU A 132
ASP A 160
TYR A 183
 None
 0.71A 2yvlC-1o54A:
23.8		 2yvlC-1o54A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 108
GLY A 110
ALA A 113
ASP A 176
VAL A 177
 None
None
CL  A 266 (-3.6A)
None
None
 0.43A 2yvlD-1o54A:
27.9		 2yvlD-1o54A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 108
GLY A 110
GLY A 112
ASP A 160
ILE A 161
 None
 0.61A 3ihtA-1o54A:
11.7		 3ihtA-1o54A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 110
GLY A 112
ASP A 160
ILE A 161
ASP A 176
 None
 0.51A 3ihtA-1o54A:
11.7		 3ihtA-1o54A:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 ILE A  83
VAL A  84
GLY A 110
ALA A 113
ILE A 161
PRO A 178
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 (-3.6A)
None
None
 0.53A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 ILE A  83
VAL A  84
GLY A 110
ALA A 113
ILE A 161
TYR A 183
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 (-3.6A)
None
None
 1.18A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 ILE A  83
VAL A  84
GLY A 110
SER A 111
ILE A 161
PRO A 178
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 ( 4.4A)
None
None
 0.87A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 12 ILE A  83
VAL A  84
GLY A 110
SER A 111
ILE A 161
TYR A 183
 CL  A 266 ( 4.7A)
CL  A 266 (-4.4A)
None
CL  A 266 ( 4.4A)
None
None
 1.45A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 GLY A 108
GLU A 132
ASP A 160
ASP A 176
 None
 0.39A 3mb5A-1o54A:
29.5		 3mb5A-1o54A:
36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 108
GLU A 132
ASP A 160
ASP A 176
VAL A 177
 None
 0.80A 3nvkF-1o54A:
undetectable
3nvkJ-1o54A:
16.3		 3nvkF-1o54A:
23.64
3nvkJ-1o54A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 LEU A  16
VAL A  26
VAL A  46
ASP A  12
 None
 0.93A 3rgfA-1o54A:
undetectable		 3rgfA-1o54A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 GLY A 110
GLU A 132
ASP A 160
ASP A 176
 None
 0.43A 3vywC-1o54A:
12.1		 3vywC-1o54A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 ALA A 130
VAL A 128
ASP A 106
LEU A 145
 None
 1.43A 4e7gA-1o54A:
2.2		 4e7gA-1o54A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		6 / 7 GLY A 108
GLY A 110
SER A 111
GLU A 132
ASP A 160
ASP A 176
 None
None
CL  A 266 ( 4.4A)
None
None
None
 0.70A 5ergB-1o54A:
23.9		 5ergB-1o54A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASP A 160
ASP A 176
GLY A 110
SER A 111
GLU A 132
 None
None
None
CL  A 266 ( 4.4A)
None
 1.08A 5hfjD-1o54A:
4.1		 5hfjD-1o54A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASP A 160
ASP A 176
GLY A 110
SER A 111
GLU A 132
 None
None
None
CL  A 266 ( 4.4A)
None
 1.11A 5hfjE-1o54A:
4.2		 5hfjE-1o54A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASP A 160
ASP A 176
GLY A 110
SER A 111
GLU A 132
 None
None
None
CL  A 266 ( 4.4A)
None
 1.10A 5hfjF-1o54A:
4.2		 5hfjF-1o54A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 THR A 249
HIS A 248
ALA A 250
ASP A  88
 None
 1.32A 5mfxA-1o54A:
3.1		 5mfxA-1o54A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 GLY A 108
GLU A 132
LYS A 133
ASP A 160
 None
 0.74A 5mvsA-1o54A:
13.1		 5mvsA-1o54A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 ASP A 106
GLY A 108
GLY A 110
ASP A 160
PHE A 174
 None
 0.87A 6nj9K-1o54A:
12.9		 6nj9K-1o54A:
21.55