SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		4 / 4 ARG L  39
ALA L  38
ALA L  53
GLU L  46
 None
 1.08A 1e7bA-1o5eL:
undetectable		 1e7bA-1o5eL:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 PRO L   8
LEU L   6
GLN L  10
 None
 0.68A 3hznG-1o5eL:
0.0
3hznH-1o5eL:
0.0		 3hznG-1o5eL:
21.70
3hznH-1o5eL:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 ASP L 107
PHE L  50
SER L  13
 None
 1.01A 3i5uB-1o5eL:
undetectable		 3i5uB-1o5eL:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 VAL L  40
SER L  44
LEU L  31
 None
 0.76A 3n8xA-1o5eL:
undetectable		 3n8xA-1o5eL:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		5 / 11 LEU L  80
GLY L  42
ALA L  41
SER L  44
LEU L  18
 None
 1.16A 3n8yA-1o5eL:
0.0		 3n8yA-1o5eL:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 ASN L  37
LEU L  86
PHE L 100
 None
 0.79A 4dajB-1o5eL:
undetectable		 4dajB-1o5eL:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1o5e SERINE PROTEASE
HEPSIN
(Homo
sapiens) 		3 / 3 ASN L  37
LEU L  86
PHE L 100
 None
 0.73A 5dsgA-1o5eL:
undetectable		 5dsgA-1o5eL:
14.21