SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 12 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 0.92A 1fe2A-1o5hA:
undetectable		 1fe2A-1o5hA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 12 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 0.79A 1igxA-1o5hA:
undetectable		 1igxA-1o5hA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 9 LEU A  73
GLU A  40
ALA A  65
GLU A  58
LEU A 126
 None
 1.42A 2azqA-1o5hA:
1.1		 2azqA-1o5hA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		3 / 3 VAL A  55
GLU A  53
GLU A  56
 None
 0.78A 2nv4A-1o5hA:
undetectable		 2nv4A-1o5hA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		3 / 3 GLY A  25
ASP A  80
SER A  29
 None
 0.72A 2qhfA-1o5hA:
1.9		 2qhfA-1o5hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		3 / 3 CYH A 145
HIS A 146
PHE A 149
 None
 0.98A 3cr4X-1o5hA:
undetectable		 3cr4X-1o5hA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 12 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 0.79A 3hs6B-1o5hA:
undetectable		 3hs6B-1o5hA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 12 LEU A 119
ALA A  65
GLU A  67
ALA A  43
ALA A  37
 None
 1.00A 3mdvB-1o5hA:
undetectable		 3mdvB-1o5hA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 12 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 0.98A 4e1gA-1o5hA:
undetectable		 4e1gA-1o5hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 12 GLY A  25
ALA A  26
SER A  29
GLY A  32
LEU A  73
 None
 1.00A 4e1gB-1o5hA:
undetectable		 4e1gB-1o5hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		4 / 4 HIS A 121
GLU A 184
HIS A 146
LEU A 139
 None
 1.48A 4m2rA-1o5hA:
undetectable		 4m2rA-1o5hA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		4 / 4 LEU A  38
MET A  41
VAL A  42
ASN A 131
 None
 1.39A 5b8iB-1o5hA:
undetectable		 5b8iB-1o5hA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		5 / 10 PHE A 149
ILE A 113
ASP A  80
GLY A  25
ALA A 105
 None
 1.47A 5x66D-1o5hA:
undetectable		 5x66D-1o5hA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1o5h FORMIMINOTETRAHYDROF
OLATE CYCLODEAMINASE
(Thermotoga
maritima) 		4 / 7 LEU A 194
LEU A 139
ALA A 141
ALA A 142
 None
 0.72A 6a7jA-1o5hA:
undetectable		 6a7jA-1o5hA:
16.41