SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY
(Thermotoga
maritima) 		3 / 3 ASP A 111
PHE A 108
LEU A 104
 None
 0.44A 2zi9A-1o5lA:
undetectable		 2zi9A-1o5lA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY
(Thermotoga
maritima) 		3 / 3 PHE A 108
ILE A  61
ASP A   2
 None
 0.65A 5cswB-1o5lA:
undetectable		 5cswB-1o5lA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY
(Thermotoga
maritima) 		5 / 12 ILE A  67
LEU A   7
ILE A  86
VAL A  12
PHE A  74
 None
 0.95A 5mugA-1o5lA:
undetectable		 5mugA-1o5lA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1o5l TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY
(Thermotoga
maritima) 		3 / 3 THR A  50
PRO A  75
ARG A  73
 None
 0.88A 5nd7B-1o5lA:
undetectable		 5nd7B-1o5lA:
18.79