SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
 0.54A 1upfA-1o5oA:
27.4		 1upfA-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 7 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
 0.55A 1upfB-1o5oA:
27.5		 1upfB-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 5 MET A 133
ALA A 135
TYR A 193
ILE A 194
ASP A 200
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
U5P  A 600 (-4.0A)
 0.50A 1upfC-1o5oA:
27.5		 1upfC-1o5oA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 4 MET A 133
ALA A 135
TYR A 193
ILE A 194
 U5P  A 600 (-4.5A)
U5P  A 600 (-3.4A)
U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
 0.47A 1upfD-1o5oA:
27.6		 1upfD-1o5oA:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 5 LEU A 118
GLY A  98
HIS A  99
ILE A 100
 None
 0.80A 1xf1A-1o5oA:
2.4		 1xf1A-1o5oA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 6 LEU A 118
GLY A  98
HIS A  99
ILE A 100
 None
 0.78A 1xf1B-1o5oA:
2.7		 1xf1B-1o5oA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 6 ALA A 143
ILE A  77
LEU A 129
GLU A 113
 None
 0.90A 3r9sC-1o5oA:
undetectable		 3r9sC-1o5oA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 ALA A 135
ARG A 104
GLY A 137
ASP A 131
ILE A 179
 U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
U5P  A 600 (-3.6A)
U5P  A 600 ( 3.9A)
None
 1.28A 3wdmA-1o5oA:
2.3		 3wdmA-1o5oA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 8 LYS A 142
ALA A 143
LEU A 147
LEU A 129
 None
 0.87A 4po0A-1o5oA:
undetectable		 4po0A-1o5oA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 10 GLY A 199
ALA A 159
ILE A 161
PRO A 132
LEU A 198
 None
 1.16A 4xj7A-1o5oA:
2.7
4xj7B-1o5oA:
undetectable		 4xj7A-1o5oA:
25.35
4xj7B-1o5oA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 TYR A 193
ILE A 194
GLY A 199
ALA A 135
ARG A 104
 U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
None
U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
 0.93A 4yp2B-1o5oA:
undetectable		 4yp2B-1o5oA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 TYR A 193
ILE A 194
GLY A 199
ALA A 135
ARG A 104
 U5P  A 600 (-4.4A)
U5P  A 600 (-4.0A)
None
U5P  A 600 (-3.4A)
U5P  A 600 (-3.4A)
 0.93A 5cf9B-1o5oA:
undetectable		 5cf9B-1o5oA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 6 PHE A  29
PRO A  26
GLY A  25
THR A  24
 None
SO4  A 709 (-4.3A)
SO4  A 709 (-3.4A)
None
 0.93A 5x24A-1o5oA:
0.0		 5x24A-1o5oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1o5o URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 12 LEU A   4
GLY A 166
VAL A 177
ILE A 144
ILE A 179
 None
 0.99A 6dh6A-1o5oA:
undetectable		 6dh6A-1o5oA:
18.00