SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 ILE A 254
ASN A 250
ASN A 291
THR A 301
 None
 1.27A 1h7xA-1o5tA:
undetectable		 1h7xA-1o5tA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 ILE A 254
ASN A 250
ASN A 291
THR A 301
 None
 1.24A 1h7xB-1o5tA:
undetectable		 1h7xB-1o5tA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 ILE A 254
ASN A 250
ASN A 291
THR A 301
 None
 1.27A 1h7xC-1o5tA:
undetectable		 1h7xC-1o5tA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 ILE A 254
ASN A 250
ASN A 291
THR A 301
 None
 1.27A 1h7xD-1o5tA:
undetectable		 1h7xD-1o5tA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 GLN A 145
LEU A 335
LEU A 116
SER A 110
 None
 0.88A 1hk3A-1o5tA:
undetectable		 1hk3A-1o5tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 434
VAL A 437
LEU A 441
 None
 0.44A 1mz9B-1o5tA:
undetectable		 1mz9B-1o5tA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 HIS A 130
PHE A 177
LEU A 174
ILE A 175
 None
 1.15A 1sbrA-1o5tA:
0.0
1sbrB-1o5tA:
undetectable		 1sbrA-1o5tA:
19.16
1sbrB-1o5tA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ASP A 198
MET A 195
ASP A 197
ASP A 237
 None
 1.48A 1t03A-1o5tA:
undetectable		 1t03A-1o5tA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		8 / 12 THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
LYS A 200
ILE A 307
PHE A 317
 None
 0.73A 2akeA-1o5tA:
54.6		 2akeA-1o5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		7 / 12 TYR A 159
GLY A 161
GLY A 163
THR A 196
GLU A 199
LYS A 200
GLN A 284
 None
 0.72A 2akeA-1o5tA:
54.6		 2akeA-1o5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		8 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
LYS A 200
ILE A 307
 None
 0.50A 2akeA-1o5tA:
54.6		 2akeA-1o5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		7 / 12 THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
ILE A 307
PHE A 317
 None
 0.76A 2azxA-1o5tA:
54.0		 2azxA-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		7 / 12 TYR A 159
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
 None
 0.72A 2azxA-1o5tA:
54.0		 2azxA-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		8 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
ILE A 307
 None
 0.43A 2azxA-1o5tA:
54.0		 2azxA-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 8 ILE A 178
PHE A 406
LEU A 441
ILE A 442
HIS A 445
 None
 0.87A 2azxA-1o5tA:
54.0		 2azxA-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 8 LEU A 174
ILE A 178
PHE A 406
GLU A 408
HIS A 445
 None
 0.71A 2azxA-1o5tA:
54.0		 2azxA-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 8 LEU A 174
ILE A 178
PHE A 406
ILE A 442
HIS A 445
 None
 0.49A 2azxA-1o5tA:
54.0		 2azxA-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 12 THR A 160
GLY A 161
GLY A 163
GLU A 199
ILE A 307
PHE A 317
 None
 0.74A 2azxB-1o5tA:
54.2		 2azxB-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		7 / 12 TYR A 159
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
 None
 0.72A 2azxB-1o5tA:
54.2		 2azxB-1o5tA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		8 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
ILE A 307
 None
 0.44A 2azxB-1o5tA:
54.2		 2azxB-1o5tA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 TYR A 420
ASP A 397
SER A 378
HIS A 387
 None
 1.09A 2bteA-1o5tA:
0.0		 2bteA-1o5tA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 TYR A 420
ASP A 397
SER A 378
HIS A 387
 None
 1.04A 2bteD-1o5tA:
9.5		 2bteD-1o5tA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 GLY A 161
GLY A 163
GLU A 199
ILE A 307
PHE A 317
 None
 0.79A 2dr2A-1o5tA:
54.4		 2dr2A-1o5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		7 / 11 TYR A 159
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
 None
 0.69A 2dr2A-1o5tA:
54.4		 2dr2A-1o5tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		7 / 11 TYR A 159
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
ILE A 307
 None
 0.49A 2dr2A-1o5tA:
54.4		 2dr2A-1o5tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
 1.13A 2q6hA-1o5tA:
0.0		 2q6hA-1o5tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
 1.13A 2qb4A-1o5tA:
0.0		 2qb4A-1o5tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 VAL A 216
LYS A 220
ILE A 223
GLY A 226
 None
 0.63A 3bjwB-1o5tA:
undetectable		 3bjwB-1o5tA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ILE A 193
MET A 241
PHE A 247
LEU A 202
ILE A 283
 None
 1.31A 3em0B-1o5tA:
0.0		 3em0B-1o5tA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 5 GLU A 429
GLY A 428
TYR A 420
ASP A 397
 None
 0.94A 3w9tD-1o5tA:
undetectable		 3w9tD-1o5tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 PHE A 280
GLY A 163
GLY A 161
ALA A 215
ASP A 198
 None
 1.16A 4a6dA-1o5tA:
undetectable		 4a6dA-1o5tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 PHE A 280
GLY A 163
GLY A 161
ALA A 215
ASP A 198
 None
 1.14A 4a6eA-1o5tA:
undetectable		 4a6eA-1o5tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 5 LEU A 441
HIS A 130
GLU A 408
HIS A 129
 None
 1.33A 4a7bB-1o5tA:
undetectable		 4a7bB-1o5tA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 TYR A 159
GLU A 199
THR A 196
GLN A 284
 None
 1.24A 4qztA-1o5tA:
undetectable		 4qztA-1o5tA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 TYR A 159
GLU A 199
THR A 196
GLN A 284
 None
 1.25A 4qzuC-1o5tA:
undetectable		 4qzuC-1o5tA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 10 ASP A 395
ASN A 393
HIS A 387
LEU A 430
THR A 427
 None
 1.42A 4yhaF-1o5tA:
undetectable		 4yhaF-1o5tA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ASP A 397
HIS A 387
THR A 427
PHE A 400
GLY A 392
 None
 1.33A 5hfjB-1o5tA:
undetectable		 5hfjB-1o5tA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 ARG A 133
ILE A 136
PHE A 131
 None
 0.76A 5kirA-1o5tA:
undetectable		 5kirA-1o5tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 VAL A 189
ARG A 141
PRO A 332
 None
 0.73A 5koxA-1o5tA:
undetectable		 5koxA-1o5tA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 12 ILE A 193
GLY A 161
ASP A 197
ILE A 223
VAL A 457
ILE A 234
 None
 1.39A 6emuA-1o5tA:
undetectable		 6emuA-1o5tA:
18.16