SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.86A 1c6yA-1o5wA:
undetectable		 1c6yA-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 8 GLU A  34
LEU A  31
GLU A 453
LEU A  80
 None
 0.99A 1cmaA-1o5wA:
undetectable
1cmaB-1o5wA:
undetectable		 1cmaA-1o5wA:
11.01
1cmaB-1o5wA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 ALA A 448
GLY A 443
ARG A  79
LEU A  80
GLU A 453
 FAD  A 652 (-3.6A)
FAD  A 652 (-4.1A)
None
None
None
 1.33A 1cmcA-1o5wA:
undetectable
1cmcB-1o5wA:
undetectable		 1cmcA-1o5wA:
11.01
1cmcB-1o5wA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 ARG A  79
LEU A  80
GLU A 453
ALA A 448
GLY A 443
 None
None
None
FAD  A 652 (-3.6A)
FAD  A 652 (-4.1A)
 1.32A 1cmcA-1o5wA:
undetectable
1cmcB-1o5wA:
undetectable		 1cmcA-1o5wA:
11.01
1cmcB-1o5wA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 8 LEU A 233
ALA A  29
GLY A  22
ILE A  23
 None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.73A 1d4sB-1o5wA:
undetectable		 1d4sB-1o5wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ASP A  64
GLY A 222
VAL A  48
GLY A  49
ILE A  23
 None
None
None
None
FAD  A 652 (-4.8A)
 0.87A 1fb7A-1o5wA:
undetectable		 1fb7A-1o5wA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.91A 1hxwB-1o5wA:
undetectable		 1hxwB-1o5wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 ARG A  79
LEU A  80
GLU A 453
ALA A 448
GLY A 443
 None
None
None
FAD  A 652 (-3.6A)
FAD  A 652 (-4.1A)
 1.37A 1mjqC-1o5wA:
undetectable
1mjqD-1o5wA:
undetectable		 1mjqC-1o5wA:
11.01
1mjqD-1o5wA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ARG A  79
LEU A  80
GLU A 453
ALA A 448
GLY A 443
 None
None
None
FAD  A 652 (-3.6A)
FAD  A 652 (-4.1A)
 1.37A 1mjqI-1o5wA:
undetectable
1mjqJ-1o5wA:
undetectable		 1mjqI-1o5wA:
11.01
1mjqJ-1o5wA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ILE A 373
LEU A 376
VAL A 380
 None
 0.27A 1mz9B-1o5wA:
undetectable		 1mz9B-1o5wA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 6 ARG A 291
ILE A 273
PHE A 432
GLU A 436
 None
FAD  A 652 (-3.6A)
None
None
 1.31A 1nsiA-1o5wA:
undetectable
1nsiB-1o5wA:
undetectable		 1nsiA-1o5wA:
21.34
1nsiB-1o5wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 6 PHE A 432
GLU A 436
ARG A 291
ILE A 273
 None
None
None
FAD  A 652 (-3.6A)
 1.32A 1nsiA-1o5wA:
undetectable
1nsiB-1o5wA:
undetectable		 1nsiA-1o5wA:
21.34
1nsiB-1o5wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 6 ARG A 291
ILE A 273
PHE A 432
GLU A 436
 None
FAD  A 652 (-3.6A)
None
None
 1.30A 1nsiC-1o5wA:
0.0
1nsiD-1o5wA:
0.0		 1nsiC-1o5wA:
21.34
1nsiD-1o5wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 7 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 652 ( 4.1A)
FAD  A 652 (-4.8A)
None
 1.03A 1rxcF-1o5wA:
undetectable		 1rxcF-1o5wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 7 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 652 ( 4.1A)
FAD  A 652 (-4.8A)
None
 1.06A 1rxcL-1o5wA:
undetectable		 1rxcL-1o5wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 8 ALA A  29
GLY A  21
GLY A  20
ILE A  19
ALA A 455
 None
FAD  A 652 ( 4.3A)
FAD  A 652 (-3.3A)
FAD  A 652 (-4.8A)
None
 1.16A 1sguA-1o5wA:
undetectable		 1sguA-1o5wA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 8 ALA A  29
GLY A  22
GLY A  20
ILE A  19
ALA A 455
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.3A)
FAD  A 652 (-4.8A)
None
 1.28A 1sguA-1o5wA:
undetectable		 1sguA-1o5wA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.81A 1t7jA-1o5wA:
undetectable		 1t7jA-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A  45
ARG A  47
ILE A  23
 FAD  A 652 (-4.3A)
None
FAD  A 652 (-4.8A)
 0.66A 1uobA-1o5wA:
0.0		 1uobA-1o5wA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 7 LEU A  80
GLY A  67
VAL A 449
ILE A  77
 None
FAD  A 652 (-3.4A)
None
None
 0.69A 2aojB-1o5wA:
undetectable		 2aojB-1o5wA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 SER A 403
GLY A  22
TYR A  53
ALA A  27
ARG A  51
 FAD  A 652 ( 4.1A)
FAD  A 652 (-3.4A)
None
None
FAD  A 652 (-3.7A)
 1.38A 2avdB-1o5wA:
2.3		 2avdB-1o5wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 PHE A 411
GLY A 434
THR A 435
ALA A 438
ALA A 451
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 1.02A 2ej3B-1o5wA:
undetectable		 2ej3B-1o5wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.89A 2o4pB-1o5wA:
undetectable		 2o4pB-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ILE A  19
ILE A 430
LEU A 234
 FAD  A 652 (-4.8A)
None
None
 0.52A 2prgA-1o5wA:
undetectable		 2prgA-1o5wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.89A 2q63A-1o5wA:
undetectable		 2q63A-1o5wA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.90A 3bvbB-1o5wA:
undetectable		 3bvbB-1o5wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 8 GLY A 452
ALA A  28
VAL A  16
ILE A 471
ILE A 270
 None
 1.16A 3ekpA-1o5wA:
undetectable		 3ekpA-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 8 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.87A 3ekpA-1o5wA:
undetectable		 3ekpA-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.86A 3ekpB-1o5wA:
undetectable		 3ekpB-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.84A 3ekpC-1o5wA:
undetectable		 3ekpC-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.87A 3ekpD-1o5wA:
undetectable		 3ekpD-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.86A 3ektA-1o5wA:
undetectable		 3ektA-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.86A 3ektC-1o5wA:
undetectable		 3ektC-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.98A 3el5A-1o5wA:
undetectable		 3el5A-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 6 VAL A  93
SER A 209
LEU A 176
ILE A 207
LEU A  97
 None
None
None
None
MLG  A 709 ( 4.9A)
 1.45A 3kk6A-1o5wA:
undetectable		 3kk6A-1o5wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 6 VAL A  93
SER A 209
LEU A 176
ILE A 207
LEU A  97
 None
None
None
None
MLG  A 709 ( 4.9A)
 1.31A 3kk6B-1o5wA:
undetectable		 3kk6B-1o5wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.92A 3nujB-1o5wA:
undetectable		 3nujB-1o5wA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 GLY A  66
ILE A 304
VAL A 303
 FAD  A 652 (-4.1A)
None
None
 0.43A 3nv6A-1o5wA:
undetectable		 3nv6A-1o5wA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.80A 3oy4B-1o5wA:
undetectable		 3oy4B-1o5wA:
12.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 8 TYR A  69
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
MLG  A 709 (-3.8A)
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.74A 3po7A-1o5wA:
61.3		 3po7A-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_B_ZONB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		6 / 9 TYR A  69
ILE A 207
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
None
MLG  A 709 (-3.8A)
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.66A 3po7B-1o5wA:
61.6		 3po7B-1o5wA:
70.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.91A 3so9B-1o5wA:
undetectable		 3so9B-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 7 LEU A 233
ALA A  29
GLY A  22
ILE A  23
 None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.87A 3spkB-1o5wA:
undetectable		 3spkB-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.83A 3spkA-1o5wA:
undetectable		 3spkA-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.91A 3spkB-1o5wA:
undetectable		 3spkB-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 8 ILE A 430
ILE A 281
PHE A 283
GLU A 436
 None
 0.88A 3ua5A-1o5wA:
undetectable		 3ua5A-1o5wA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		7 / 12 PRO A 113
TRP A 128
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.76A 4a79A-1o5wA:
60.8		 4a79A-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		7 / 12 PRO A 113
TRP A 128
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.78A 4a79B-1o5wA:
61.0		 4a79B-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		6 / 11 TYR A  69
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.66A 4a7aA-1o5wA:
60.9		 4a7aA-1o5wA:
70.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		7 / 12 PRO A 113
LEU A 176
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
MLG  A 709 (-3.8A)
None
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.84A 4a7aB-1o5wA:
61.2		 4a7aB-1o5wA:
70.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 1.11A 4b7nA-1o5wA:
undetectable		 4b7nA-1o5wA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 TYR A 410
MET A 300
ILE A 273
 None
None
FAD  A 652 (-3.6A)
 0.76A 4c8bB-1o5wA:
undetectable		 4c8bB-1o5wA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 1.05A 4cpzC-1o5wA:
undetectable		 4cpzC-1o5wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 1.08A 4cpzE-1o5wA:
undetectable		 4cpzE-1o5wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 1.11A 4cpzF-1o5wA:
undetectable		 4cpzF-1o5wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 1.11A 4cpzG-1o5wA:
undetectable		 4cpzG-1o5wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 1.06A 4cpzH-1o5wA:
undetectable		 4cpzH-1o5wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.84A 4dqbB-1o5wA:
undetectable		 4dqbB-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.85A 4dqcB-1o5wA:
undetectable		 4dqcB-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.83A 4dqeB-1o5wA:
undetectable		 4dqeB-1o5wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.83A 4dqhB-1o5wA:
undetectable		 4dqhB-1o5wA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 6 TYR A 124
PRO A 114
PHE A 208
PHE A 108
 None
None
MLG  A 709 (-4.0A)
None
 1.30A 4kf9A-1o5wA:
0.0		 4kf9A-1o5wA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 VAL A 226
TRP A  62
ASP A  64
LEU A  78
THR A  54
 None
 1.16A 4kyaH-1o5wA:
undetectable		 4kyaH-1o5wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.90A 4ll3B-1o5wA:
undetectable		 4ll3B-1o5wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.84A 4njtB-1o5wA:
undetectable		 4njtB-1o5wA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.94A 4njuA-1o5wA:
undetectable		 4njuA-1o5wA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.88A 4njuB-1o5wA:
undetectable		 4njuB-1o5wA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.95A 4njuC-1o5wA:
undetectable		 4njuC-1o5wA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.89A 4njuD-1o5wA:
undetectable		 4njuD-1o5wA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 7 PHE A 432
GLU A 436
ARG A 291
ILE A 273
 None
None
None
FAD  A 652 (-3.6A)
 1.31A 4nosA-1o5wA:
undetectable
4nosB-1o5wA:
undetectable		 4nosA-1o5wA:
21.58
4nosB-1o5wA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 7 ARG A 291
ILE A 273
PHE A 432
GLU A 436
 None
FAD  A 652 (-3.6A)
None
None
 1.27A 4nosC-1o5wA:
undetectable
4nosD-1o5wA:
undetectable		 4nosC-1o5wA:
21.58
4nosD-1o5wA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 6 PHE A 432
GLU A 436
ARG A 291
ILE A 273
 None
None
None
FAD  A 652 (-3.6A)
 1.32A 4nosC-1o5wA:
0.0
4nosD-1o5wA:
0.0		 4nosC-1o5wA:
21.58
4nosD-1o5wA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.97A 4qvpH-1o5wA:
undetectable
4qvpI-1o5wA:
undetectable		 4qvpH-1o5wA:
18.82
4qvpI-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.97A 4qvpV-1o5wA:
undetectable
4qvpW-1o5wA:
undetectable		 4qvpV-1o5wA:
18.82
4qvpW-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 4qvvH-1o5wA:
undetectable		 4qvvH-1o5wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 4qvvV-1o5wA:
undetectable		 4qvvV-1o5wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 4qvyH-1o5wA:
undetectable		 4qvyH-1o5wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 4qvyV-1o5wA:
undetectable
4qvyW-1o5wA:
undetectable		 4qvyV-1o5wA:
18.82
4qvyW-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.99A 4qw0H-1o5wA:
undetectable
4qw0I-1o5wA:
undetectable		 4qw0H-1o5wA:
18.82
4qw0I-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.99A 4qw0V-1o5wA:
undetectable
4qw0W-1o5wA:
undetectable		 4qw0V-1o5wA:
18.82
4qw0W-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.96A 4qw1H-1o5wA:
undetectable
4qw1I-1o5wA:
undetectable		 4qw1H-1o5wA:
18.82
4qw1I-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.96A 4qw1V-1o5wA:
undetectable
4qw1W-1o5wA:
undetectable		 4qw1V-1o5wA:
18.82
4qw1W-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ASN A  75
GLY A 447
ARG A  79
GLU A 450
GLU A 475
 None
 1.22A 4xt8A-1o5wA:
undetectable		 4xt8A-1o5wA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 5bxnH-1o5wA:
undetectable
5bxnI-1o5wA:
undetectable		 5bxnH-1o5wA:
18.82
5bxnI-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 5cz7V-1o5wA:
undetectable
5cz7W-1o5wA:
undetectable		 5cz7V-1o5wA:
18.82
5cz7W-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 5d0xV-1o5wA:
undetectable		 5d0xV-1o5wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 10 LEU A  31
GLU A 453
ARG A  79
GLY A 232
LEU A 234
 None
 1.29A 5dx3A-1o5wA:
undetectable		 5dx3A-1o5wA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A  28
GLU A 453
LEU A  80
ARG A  79
GLY A  49
 None
 1.22A 5dxbB-1o5wA:
undetectable		 5dxbB-1o5wA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A  28
GLU A 453
LEU A  80
ARG A  79
GLY A  49
 None
 1.23A 5dxgB-1o5wA:
0.0		 5dxgB-1o5wA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 GLY A  25
GLY A  21
ILE A 273
ILE A 230
LEU A  40
 None
FAD  A 652 ( 4.3A)
FAD  A 652 (-3.6A)
None
None
 1.14A 5fa8A-1o5wA:
3.4		 5fa8A-1o5wA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ILE A 161
VAL A 189
HIS A 187
ALA A 302
VAL A 182
 None
 0.96A 5igtA-1o5wA:
undetectable		 5igtA-1o5wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 8 SER A 442
THR A 408
PRO A 143
ILE A 423
 None
 0.98A 5jhdE-1o5wA:
0.0
5jhdG-1o5wA:
0.0		 5jhdE-1o5wA:
18.84
5jhdG-1o5wA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		3 / 3 VAL A 178
ARG A 297
PRO A 299
 None
 0.86A 5koxA-1o5wA:
12.0		 5koxA-1o5wA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.85A 5kr0B-1o5wA:
undetectable		 5kr0B-1o5wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 5l5fH-1o5wA:
undetectable
5l5fI-1o5wA:
undetectable		 5l5fH-1o5wA:
18.82
5l5fI-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 5l5fV-1o5wA:
undetectable
5l5fW-1o5wA:
undetectable		 5l5fV-1o5wA:
18.82
5l5fW-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 5l66H-1o5wA:
undetectable
5l66I-1o5wA:
undetectable		 5l66H-1o5wA:
18.82
5l66I-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.99A 5l66V-1o5wA:
undetectable
5l66W-1o5wA:
undetectable		 5l66V-1o5wA:
18.82
5l66W-1o5wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.85A 5t2zB-1o5wA:
undetectable		 5t2zB-1o5wA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 5 GLY A 203
ARG A 206
ASP A 132
MET A 131
 None
 1.29A 5ubbA-1o5wA:
undetectable		 5ubbA-1o5wA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 GLY A 447
GLY A  25
GLY A 452
GLU A 453
VAL A  41
 None
 0.97A 5vimA-1o5wA:
undetectable		 5vimA-1o5wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		4 / 8 GLN A 229
GLY A 224
ILE A  23
GLN A  74
 None
None
FAD  A 652 (-4.8A)
FAD  A 652 ( 4.1A)
 0.78A 5vlmH-1o5wA:
0.2		 5vlmH-1o5wA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		6 / 12 GLY A  25
GLY A 452
VAL A  41
ILE A  23
LEU A  26
LEU A 234
 None
None
None
FAD  A 652 (-4.8A)
None
None
 1.24A 5wy0A-1o5wA:
undetectable		 5wy0A-1o5wA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.81A 6dh0A-1o5wA:
undetectable		 6dh0A-1o5wA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.90A 6dilA-1o5wA:
undetectable		 6dilA-1o5wA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 652 (-3.4A)
FAD  A 652 (-4.8A)
 0.87A 6dilB-1o5wA:
undetectable		 6dilB-1o5wA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 6hwdH-1o5wA:
undetectable
6hwdI-1o5wA:
undetectable		 6hwdH-1o5wA:
11.50
6hwdI-1o5wA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 652 (-3.4A)
FAD  A 652 (-3.6A)
None
None
 0.98A 6hwdV-1o5wA:
undetectable		 6hwdV-1o5wA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 12 ILE A  19
GLY A  20
GLY A  22
ALA A  27
VAL A 244
 FAD  A 652 (-4.8A)
FAD  A 652 (-3.3A)
FAD  A 652 (-3.4A)
None
FAD  A 652 (-3.9A)
 0.69A 6iftA-1o5wA:
undetectable		 6iftA-1o5wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Rattus
norvegicus) 		5 / 9 ILE A 270
ALA A 272
GLY A  25
LEU A  26
GLY A 447
 None
 1.29A 6nm4B-1o5wA:
undetectable		 6nm4B-1o5wA:
14.81