SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		3 / 3 ALA A 212
VAL A 207
TRP A 183
 None
 0.94A 1c4dC-1o5zA:
undetectable
1c4dD-1o5zA:
undetectable		 1c4dC-1o5zA:
2.77
1c4dD-1o5zA:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 LEU A  23
GLY A 187
GLY A 148
LEU A 146
GLY A 145
 None
None
None
SO4  A 501 (-4.2A)
UNL  A 701 ( 3.6A)
 0.88A 1y4lA-1o5zA:
undetectable		 1y4lA-1o5zA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 10 ALA A 402
SER A 334
LEU A 333
PHE A 356
LEU A 324
 None
CL  A 601 (-2.9A)
None
None
None
 1.15A 1y7iB-1o5zA:
2.0		 1y7iB-1o5zA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 TYR A 242
VAL A 196
VAL A  58
VAL A  54
 None
 1.00A 2qbnA-1o5zA:
0.0		 2qbnA-1o5zA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 12 THR A 270
LEU A 271
ARG A 295
GLN A 260
VAL A 164
 None
None
SO4  A 502 (-3.4A)
None
None
 1.32A 2vaxH-1o5zA:
2.1		 2vaxH-1o5zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 6 ILE A 178
ILE A  45
GLY A  47
VAL A 221
 None
None
SO4  A 501 (-4.5A)
None
 0.98A 3n3iA-1o5zA:
undetectable		 3n3iA-1o5zA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 5 LEU A 299
THR A 420
GLU A 297
HIS A 236
 None
 1.15A 3n58C-1o5zA:
2.2		 3n58C-1o5zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 4 PHE A  80
THR A  79
LEU A   7
TYR A   3
 None
 1.36A 3pgyB-1o5zA:
0.7		 3pgyB-1o5zA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 ILE A 339
GLY A 338
PHE A 383
LEU A 335
 None
 0.82A 3v7pA-1o5zA:
undetectable		 3v7pA-1o5zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 6 GLY A 338
VAL A 364
GLY A 413
TYR A 414
 None
 0.86A 4dxuA-1o5zA:
undetectable		 4dxuA-1o5zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 9 PHE A 296
GLY A 413
GLY A 294
LEU A  77
GLU A  82
 None
 1.32A 4l8wG-1o5zA:
2.9		 4l8wG-1o5zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 4 LEU A 253
ARG A 239
ILE A 261
PHE A 240
 None
 1.11A 5kirB-1o5zA:
0.0		 5kirB-1o5zA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		5 / 10 PRO A  75
HIS A  76
ALA A  55
GLY A  46
ILE A  45
 None
CL  A 602 (-4.7A)
None
None
None
 1.22A 5vyhA-1o5zA:
0.0		 5vyhA-1o5zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 8 VAL A 155
PRO A  36
GLY A  34
LEU A  33
 None
 0.91A 5w3jB-1o5zA:
undetectable		 5w3jB-1o5zA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE
(Thermotoga
maritima) 		4 / 7 ASN A 292
GLY A 316
ALA A 317
VAL A 404
 SO4  A 502 (-3.1A)
None
None
None
 0.76A 6dwnB-1o5zA:
0.0		 6dwnB-1o5zA:
9.56