SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 10 ASP A 199
ASN A 136
ILE A 111
GLU A 239
GLY A  24
 None
 1.18A 1mehA-1o60A:
5.6		 1mehA-1o60A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 8 ASP A 199
ASN A 136
ILE A 111
GLY A  24
 None
 0.98A 1meiA-1o60A:
12.1		 1meiA-1o60A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A 236
LEU A 229
ALA A 230
ILE A 270
SER A 227
 None
 1.13A 2bxpA-1o60A:
undetectable		 2bxpA-1o60A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 LEU A  28
VAL A 137
ILE A  93
MET A  74
 None
 1.17A 2hyyC-1o60A:
undetectable		 2hyyC-1o60A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 8 GLY A   9
ASP A 110
ILE A 111
VAL A  13
 None
 0.80A 3fi0I-1o60A:
undetectable		 3fi0I-1o60A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 SER A  57
GLN A 113
PHE A 237
HIS A 202
 None
 1.34A 3lskB-1o60A:
0.1		 3lskB-1o60A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 SER A  57
GLN A 113
PHE A 237
HIS A 202
 None
 1.33A 3lskD-1o60A:
0.0		 3lskD-1o60A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 11 TYR A  52
VAL A  90
ILE A 111
ALA A  56
THR A  94
 None
 1.08A 3mdtB-1o60A:
0.0		 3mdtB-1o60A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 9 TYR A  52
ILE A  92
ILE A  93
VAL A  90
ILE A   8
 None
 1.32A 3p4wA-1o60A:
0.0		 3p4wA-1o60A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 9 GLN A 113
ILE A 112
THR A 201
PHE A 237
GLU A 239
 None
 1.36A 3qelD-1o60A:
1.6		 3qelD-1o60A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 ILE A 163
LEU A 165
GLU A 153
ALA A 190
 None
 0.83A 3r9sA-1o60A:
undetectable		 3r9sA-1o60A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 7 ILE A 163
LEU A 165
GLU A 153
ALA A 190
 None
 0.80A 3r9tB-1o60A:
undetectable		 3r9tB-1o60A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 PHE A 184
LEU A 224
ALA A 225
LEU A  21
LEU A 236
 None
 0.91A 4dm8B-1o60A:
undetectable		 4dm8B-1o60A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		3 / 3 LEU A 229
MET A 267
ASP A  12
 None
 0.74A 4j7xB-1o60A:
undetectable		 4j7xB-1o60A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 10 PRO A  18
LEU A 229
PHE A 263
VAL A 264
PRO A  51
 None
 1.39A 5m0oA-1o60A:
undetectable		 5m0oA-1o60A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 10 TYR A  52
ILE A  92
ILE A  93
VAL A  90
ILE A   8
 None
 1.38A 5mvnD-1o60A:
undetectable		 5mvnD-1o60A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		3 / 3 LYS A   4
LYS A 188
SER A 191
 None
 1.23A 5odiA-1o60A:
undetectable		 5odiA-1o60A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		3 / 3 MET A 267
GLU A 223
ARG A 226
 None
 1.03A 5tjyA-1o60A:
undetectable		 5tjyA-1o60A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		3 / 3 MET A 267
GLU A 223
ARG A 226
 None
 1.02A 5tjzA-1o60A:
undetectable		 5tjzA-1o60A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 GLY A 228
SER A 227
CYH A 166
ASP A 167
PHE A 184
 None
 1.44A 5vlmF-1o60A:
undetectable		 5vlmF-1o60A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 5 ARG A  63
ARG A  70
GLY A  71
ASP A  59
 None
 1.38A 6dwjB-1o60A:
0.0
6dwjD-1o60A:
undetectable		 6dwjB-1o60A:
18.59
6dwjD-1o60A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		4 / 7 VAL A  50
ILE A  11
GLY A 193
ALA A 234
 None
 0.69A 6hd6B-1o60A:
undetectable		 6hd6B-1o60A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Haemophilus
influenzae) 		5 / 10 THR A  94
GLY A  73
GLY A  77
VAL A 105
GLU A  76
 None
 1.24A 6nqaK-1o60A:
undetectable		 6nqaK-1o60A:
22.25