SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		4 / 6 SER A 194
ALA A 173
THR A 122
ALA A 167
 None
 1.00A 1w0gA-1o66A:
undetectable		 1w0gA-1o66A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		5 / 11 LEU A 217
HIS A 214
MET A 213
SER A  26
HIS A 235
 None
 1.31A 2idkA-1o66A:
1.1
2idkB-1o66A:
1.1
2idkC-1o66A:
1.3
2idkD-1o66A:
1.3		 2idkA-1o66A:
23.01
2idkB-1o66A:
23.01
2idkC-1o66A:
23.01
2idkD-1o66A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		5 / 12 GLN A 239
ALA A  34
GLY A  73
ASP A  32
LEU A  30
 None
 1.34A 2nv4A-1o66A:
0.0		 2nv4A-1o66A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		5 / 12 GLN A 239
ALA A  34
GLY A  73
ASP A  32
LEU A  30
 None
 1.37A 2nv4B-1o66A:
0.0		 2nv4B-1o66A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		3 / 3 MET A 216
MET A  47
PHE A  27
 None
 1.07A 3gn8A-1o66A:
0.0		 3gn8A-1o66A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		4 / 8 ILE A 136
ALA A 119
THR A 122
VAL A 176
 None
 0.86A 3me6B-1o66A:
0.0		 3me6B-1o66A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		4 / 6 VAL A 175
LEU A   7
ILE A  17
VAL A  80
 None
 0.80A 4a9kA-1o66A:
undetectable		 4a9kA-1o66A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		3 / 3 LEU A 217
MET A 232
ASP A  32
 None
 0.81A 4j7xB-1o66A:
undetectable		 4j7xB-1o66A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		4 / 7 VAL A 110
LEU A 125
THR A 122
THR A 121
 None
 0.89A 5m78A-1o66A:
undetectable		 5m78A-1o66A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1o66 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Neisseria
meningitidis) 		4 / 6 SER A 194
ALA A 173
THR A 122
ALA A 167
 None
 1.07A 6ma6A-1o66A:
0.0		 6ma6A-1o66A:
15.61