SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 12 ILE A 144
LEU A  26
PHE A 141
ILE A  95
LEU A   1
 None
 1.06A 1rx3A-1o6dA:
undetectable		 1rx3A-1o6dA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 12 ILE A 144
LEU A  26
PHE A 141
ILE A  95
LEU A   1
 None
 1.01A 1rx8A-1o6dA:
undetectable		 1rx8A-1o6dA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 12 THR A 129
GLY A 101
ILE A  99
THR A  53
GLU A 107
 None
 1.14A 1vq1A-1o6dA:
undetectable		 1vq1A-1o6dA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		4 / 8 LEU A 134
ILE A  19
GLU A  36
ILE A  97
 None
 0.93A 2azxA-1o6dA:
undetectable		 2azxA-1o6dA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 12 ILE A   5
PHE A  81
LEU A  85
GLU A  23
LEU A  26
 None
 1.18A 2bxfA-1o6dA:
undetectable		 2bxfA-1o6dA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 9 LEU A 131
LEU A 134
ILE A   5
LEU A  11
ILE A  15
 None
 1.26A 2f78A-1o6dA:
3.1		 2f78A-1o6dA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 9 LEU A 131
LEU A 134
ILE A   5
LEU A  11
ILE A  15
 None
 1.27A 2f78B-1o6dA:
1.1		 2f78B-1o6dA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		4 / 4 LEU A  56
THR A  57
ILE A  48
HIS A  41
 None
 1.32A 2jfaB-1o6dA:
undetectable		 2jfaB-1o6dA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 9 ILE A  99
GLY A 100
GLY A 104
SER A 118
SER A 120
 None
 0.69A 2qmmA-1o6dA:
8.4		 2qmmA-1o6dA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		6 / 11 ILE A  99
GLY A 100
GLY A 104
SER A 118
LEU A 119
SER A 120
 None
 0.76A 2qmmA-1o6dA:
8.4
2qmmB-1o6dA:
8.1		 2qmmA-1o6dA:
24.88
2qmmB-1o6dA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 9 ILE A  99
GLY A 100
SER A 118
LEU A 119
SER A 120
 None
 0.61A 3ai9X-1o6dA:
7.9		 3ai9X-1o6dA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		3 / 3 LYS A  38
VAL A  40
HIS A  41
 None
 1.14A 3tj7A-1o6dA:
undetectable		 3tj7A-1o6dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		4 / 6 LYS A  16
ILE A  19
VAL A 130
LEU A 131
 None
 1.06A 4em2A-1o6dA:
undetectable		 4em2A-1o6dA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 10 GLY A 101
GLY A 104
SER A 120
THR A 123
PHE A 124
 None
 1.06A 4fakA-1o6dA:
22.1		 4fakA-1o6dA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		6 / 10 ILE A  99
GLY A 100
GLY A 104
SER A 120
THR A 123
PHE A 124
 None
 0.34A 4fakA-1o6dA:
22.1		 4fakA-1o6dA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		4 / 8 GLY A   9
GLY A 100
LEU A 105
VAL A  49
 None
 0.90A 4fgzA-1o6dA:
undetectable		 4fgzA-1o6dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		4 / 8 GLY A   9
GLY A 100
LEU A 105
VAL A  49
 None
 0.91A 4fgzB-1o6dA:
undetectable		 4fgzB-1o6dA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		3 / 3 HIS A 145
LYS A 142
PHE A  29
 None
 1.32A 5klaA-1o6dA:
undetectable		 5klaA-1o6dA:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		7 / 12 ILE A  99
GLY A 100
GLY A 104
SER A 118
LEU A 119
SER A 120
THR A 123
 None
 0.55A 5twjA-1o6dA:
22.1		 5twjA-1o6dA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		7 / 12 ILE A  99
GLY A 100
SER A 118
LEU A 119
SER A 120
THR A 123
HIS A 126
 None
 0.45A 5twjA-1o6dA:
22.1		 5twjA-1o6dA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 10 ILE A  99
GLY A 100
GLY A 104
LEU A 119
SER A 120
 None
 0.40A 5twjB-1o6dA:
21.9		 5twjB-1o6dA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		5 / 10 ILE A  99
GLY A 100
LEU A 119
SER A 120
HIS A 126
 None
 0.46A 5twjB-1o6dA:
21.9		 5twjB-1o6dA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		7 / 12 ASP A  70
ILE A  99
GLY A 100
LEU A 105
SER A 118
LEU A 119
SER A 120
 None
 0.44A 5twjC-1o6dA:
22.2		 5twjC-1o6dA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		7 / 11 ASP A  70
ILE A  99
GLY A 100
GLY A 104
LEU A 119
SER A 120
THR A 123
 None
 0.54A 5twjD-1o6dA:
22.1		 5twjD-1o6dA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844
(Thermotoga
maritima) 		6 / 11 ILE A  99
GLY A 100
GLY A 101
LEU A 119
SER A 120
THR A 123
 None
 1.16A 5twjD-1o6dA:
22.1		 5twjD-1o6dA:
32.75