SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		5 / 8 ARG A 214
LEU A 218
ASP A 221
ILE A 227
GLY A  11
 None
 1.11A 2o4nB-1o6eA:
undetectable		 2o4nB-1o6eA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		5 / 9 ALA A  52
LEU A 201
LEU A 112
ILE A  85
THR A  45
 None
 1.29A 3freX-1o6eA:
undetectable		 3freX-1o6eA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		5 / 12 ILE A  73
LEU A 196
PHE A  78
SER A  84
ILE A  85
 None
 1.19A 3ia4D-1o6eA:
undetectable		 3ia4D-1o6eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		4 / 8 ILE A 142
ALA A 107
VAL A   7
VAL A   9
 None
 0.86A 3me6B-1o6eA:
undetectable		 3me6B-1o6eA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		5 / 9 VAL A  54
ILE A 142
ALA A 107
VAL A   7
VAL A   9
 None
 1.02A 3me6C-1o6eA:
undetectable		 3me6C-1o6eA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		5 / 12 ALA A 118
LEU A  42
TYR A 155
VAL A  13
TYR A  61
 ISP  A1236 ( 4.7A)
None
None
None
None
 1.48A 5vlmD-1o6eA:
undetectable		 5vlmD-1o6eA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1o6e CAPSID PROTEIN P40
(Human
gammaherpesvirus
4) 		4 / 6 LEU A 201
VAL A  46
LEU A 112
VAL A  54
 None
 0.97A 5x7zA-1o6eA:
undetectable		 5x7zA-1o6eA:
22.80