SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 7 LEU A  30
ILE A  71
ARG A 126
SER A  73
 None
 0.90A 2hc4A-1o6uA:
0.1		 2hc4A-1o6uA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 7 ASP A 235
VAL A  98
ILE A 152
SER A 233
 None
 0.96A 3pglA-1o6uA:
undetectable		 3pglA-1o6uA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens) 		4 / 7 ILE A 264
GLY A 110
SER A 114
LEU A 120
 None
 0.78A 3v7pA-1o6uA:
undetectable		 3v7pA-1o6uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 ILE A 258
VAL A 237
ASP A  92
THR A 150
ILE A 152
 None
 1.44A 4xe0A-1o6uA:
undetectable		 4xe0A-1o6uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens) 		5 / 12 TYR A 241
VAL A 237
ASP A  92
THR A 150
ILE A 152
 None
 1.40A 4xe0A-1o6uA:
undetectable		 4xe0A-1o6uA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens) 		3 / 3 ASP A 313
SER A 370
TYR A 369
 None
 0.91A 5glmA-1o6uA:
0.0		 5glmA-1o6uA:
22.35