SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		5 / 12 LEU A 544
LEU A 496
GLY A 607
TYR A 505
ASN A 606
 None
 0.99A 2bm9C-1o70A:
undetectable		 2bm9C-1o70A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		5 / 9 THR A 504
LEU A 568
VAL A 566
ILE A 588
VAL A 579
 None
 1.49A 2l8mA-1o70A:
0.0		 2l8mA-1o70A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 6 PHE A 336
LEU A 348
VAL A 347
VAL A 357
 None
 1.19A 2zawA-1o70A:
0.0		 2zawA-1o70A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 8 PHE A 419
GLY A 437
VAL A 435
LEU A 360
 None
 1.10A 3bgdB-1o70A:
undetectable		 3bgdB-1o70A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 5 LEU A 471
ARG A 502
ILE A 546
PHE A 503
 None
 1.14A 3ln1D-1o70A:
0.0		 3ln1D-1o70A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		5 / 9 PHE A 506
LEU A 556
VAL A 579
LEU A 575
ILE A 577
 None
 0.88A 3tbgD-1o70A:
undetectable		 3tbgD-1o70A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 5 GLY A 438
ILE A 385
LYS A 381
GLN A 384
 None
 0.90A 4ma8C-1o70A:
undetectable		 4ma8C-1o70A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		3 / 3 LYS A 593
ILE A 595
ILE A 612
 None
 0.69A 4y0qA-1o70A:
undetectable		 4y0qA-1o70A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 5 VAL A 432
TYR A 598
ILE A 612
PRO A 478
 None
None
None
NAG  A1624 ( 4.8A)
 1.29A 4ze1A-1o70A:
0.0		 4ze1A-1o70A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		3 / 3 ASP A 460
ASN A 364
PHE A 336
 None
SO4  A1627 (-4.3A)
None
 0.80A 5dsgB-1o70A:
undetectable		 5dsgB-1o70A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		5 / 12 LYS A 620
SER A 536
ILE A 539
ARG A 542
LEU A 617
 None
None
None
SO4  A1629 (-3.5A)
None
 1.06A 5hi6A-1o70A:
undetectable		 5hi6A-1o70A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 7 HIS A 543
HIS A 610
ILE A 612
VAL A 611
 None
 1.11A 5kkzC-1o70A:
0.0
5kkzE-1o70A:
undetectable		 5kkzC-1o70A:
20.87
5kkzE-1o70A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 7 HIS A 610
ILE A 612
VAL A 611
HIS A 543
 None
 1.08A 5kkzK-1o70A:
undetectable
5kkzQ-1o70A:
0.0		 5kkzK-1o70A:
21.93
5kkzQ-1o70A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1o70 FASCICLIN I
(Drosophila
melanogaster) 		4 / 5 VAL A 622
LEU A 617
HIS A 543
THR A 516
 None
 1.13A 6dyoA-1o70A:
undetectable		 6dyoA-1o70A:
13.58