SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		5 / 12 LEU A  33
LEU A  26
LEU A   4
GLY A   3
PHE A 104
 None
 1.47A 1d4fA-1o73A:
undetectable		 1d4fA-1o73A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		5 / 12 LEU A  33
LEU A  26
LEU A   4
GLY A   3
PHE A 104
 None
 1.45A 1d4fB-1o73A:
1.9		 1d4fB-1o73A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		5 / 9 THR A  96
LEU A  89
VAL A  66
ILE A 115
VAL A  31
 None
 1.43A 2l8mA-1o73A:
0.0		 2l8mA-1o73A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		5 / 12 LEU A  33
LEU A  26
LEU A   4
GLY A   3
PHE A 104
 None
 1.41A 3g1uC-1o73A:
undetectable		 3g1uC-1o73A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		5 / 12 LEU A  33
LEU A  26
LEU A   4
GLY A   3
PHE A 104
 None
 1.41A 3glqA-1o73A:
undetectable		 3glqA-1o73A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		5 / 12 LEU A  33
LEU A  26
LEU A   4
GLY A   3
PHE A 104
 None
 1.35A 3n58A-1o73A:
undetectable		 3n58A-1o73A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		4 / 5 LEU A   8
PRO A   9
LEU A  89
ILE A  68
 None
 1.07A 4klrA-1o73A:
undetectable		 4klrA-1o73A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		4 / 8 PHE A  35
SER A  36
TRP A  86
TYR A  80
 None
 1.39A 5amiB-1o73A:
undetectable		 5amiB-1o73A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1o73 TRYPAREDOXIN
(Trypanosoma
brucei) 		3 / 3 GLY A  28
THR A  30
ASN A  62
 None
 0.64A 5odiG-1o73A:
undetectable		 5odiG-1o73A:
12.69