SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 12 VAL A 152
PHE A  67
PHE A 122
ALA A 135
PHE A  63
 None
 1.45A 3apxA-1o75A:
0.0		 3apxA-1o75A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		4 / 7 GLY A 264
ASP A 261
TYR A 262
ARG A 259
 None
 1.29A 3arrA-1o75A:
undetectable		 3arrA-1o75A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 12 GLY A  61
GLY A  59
SER A 284
GLY A 226
LEU A  45
 None
 1.05A 4fzvA-1o75A:
undetectable		 4fzvA-1o75A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 8 ALA A 161
LEU A 166
THR A 191
SER A 199
SER A 197
 None
 1.42A 4ikkA-1o75A:
undetectable
4ikkB-1o75A:
3.6		 4ikkA-1o75A:
16.87
4ikkB-1o75A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		4 / 5 GLY A 289
THR A 288
HIS A 245
GLY A 118
 PDX  A1417 (-3.2A)
None
None
None
 0.93A 4v20A-1o75A:
undetectable		 4v20A-1o75A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		4 / 5 ASP A  46
ASP A 228
PHE A 305
GLY A 301
 None
 1.23A 4xp6A-1o75A:
undetectable		 4xp6A-1o75A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		4 / 6 PHE A 405
LYS A 403
TYR A 335
ALA A 353
 None
 1.10A 4yshB-1o75A:
undetectable		 4yshB-1o75A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		5 / 12 VAL A 329
ASP A 328
ALA A 231
ARG A 259
LEU A 317
 None
None
XE  A1415 ( 4.5A)
None
None
 1.23A 5nd2B-1o75A:
undetectable		 5nd2B-1o75A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		4 / 8 LEU A 386
VAL A 379
LEU A 343
ILE A 350
 None
 0.98A 5v0vA-1o75A:
undetectable		 5v0vA-1o75A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1o75 47 KDA MEMBRANE
ANTIGEN
(Treponema
pallidum) 		4 / 6 SER A 110
ALA A 128
ALA A 109
SER A 108
 None
 1.03A 6bocA-1o75A:
undetectable
6bocB-1o75A:
undetectable
6bocC-1o75A:
undetectable
6bocD-1o75A:
undetectable		 6bocA-1o75A:
5.35
6bocB-1o75A:
5.35
6bocC-1o75A:
5.35
6bocD-1o75A:
5.35