SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o7d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 VAL A 156
VAL A 119
TRP A 155
 None
 0.92A 1bdwA-1o7dA:
undetectable
1bdwB-1o7dA:
undetectable		 1bdwA-1o7dA:
4.71
1bdwB-1o7dA:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 8 ALA B 419
LEU C 486
SER C 484
THR E 887
 None
 0.95A 1dvtA-1o7dB:
undetectable
1dvtB-1o7dB:
undetectable		 1dvtA-1o7dB:
21.31
1dvtB-1o7dB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 GLU D 728
TYR D 644
PHE D 662
 None
 0.94A 1eqbB-1o7dD:
undetectable		 1eqbB-1o7dD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 GLU D 728
TYR D 644
PHE D 662
 None
 0.94A 1eqbA-1o7dD:
undetectable		 1eqbA-1o7dD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 GLU D 728
TYR D 644
PHE D 662
 None
 0.94A 1eqbD-1o7dD:
undetectable		 1eqbD-1o7dD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 GLU D 728
TYR D 644
PHE D 662
 None
 0.94A 1eqbC-1o7dD:
undetectable		 1eqbC-1o7dD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 LEU C 480
LEU C 486
GLY C 485
ALA B 419
LEU B 418
 None
 1.18A 1gs4A-1o7dC:
undetectable		 1gs4A-1o7dC:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 SER D 803
GLU D 810
ILE D 782
ILE D 730
LEU D 811
 None
 1.20A 1kyvA-1o7dD:
undetectable
1kyvE-1o7dD:
undetectable		 1kyvA-1o7dD:
20.77
1kyvE-1o7dD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 ILE D 730
LEU D 811
SER D 803
GLU D 810
ILE D 782
 None
 1.23A 1kyvB-1o7dD:
undetectable
1kyvC-1o7dD:
undetectable		 1kyvB-1o7dD:
20.77
1kyvC-1o7dD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 ILE D 730
LEU D 811
SER D 803
GLU D 810
ILE D 782
 None
 1.22A 1kyvC-1o7dD:
undetectable
1kyvD-1o7dD:
undetectable		 1kyvC-1o7dD:
20.77
1kyvD-1o7dD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 ILE D 730
LEU D 811
SER D 803
GLU D 810
ILE D 782
 None
 1.25A 1kyvD-1o7dD:
undetectable
1kyvE-1o7dD:
undetectable		 1kyvD-1o7dD:
20.77
1kyvE-1o7dD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 7 TYR C 461
TYR B 391
GLY D 658
TRP B 388
 None
 1.04A 1mxgA-1o7dC:
4.0		 1mxgA-1o7dC:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 7 ILE D 730
PHE D 671
ARG D 638
ALA D 640
 None
 0.94A 1oniD-1o7dD:
undetectable
1oniE-1o7dD:
undetectable		 1oniD-1o7dD:
18.28
1oniE-1o7dD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 6 PHE D 671
ARG D 638
ALA D 640
ILE D 730
 None
 0.88A 1oniH-1o7dD:
undetectable
1oniI-1o7dD:
undetectable		 1oniH-1o7dD:
18.28
1oniI-1o7dD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		3 / 3 TYR B 359
ARG A 229
GLN A 234
 None
 0.94A 1tw4A-1o7dB:
undetectable		 1tw4A-1o7dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 TYR D 775
ALA D 646
TYR D 644
GLY D 726
LEU D 817
 None
 1.34A 1vpoH-1o7dD:
0.0
1vpoL-1o7dD:
0.0		 1vpoH-1o7dD:
19.80
1vpoL-1o7dD:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 6 LEU E 956
LEU E 992
LEU E 903
ILE E 990
 None
 0.97A 1z95A-1o7dE:
undetectable		 1z95A-1o7dE:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 THR C 504
PRO C 502
THR C 506
 None
 0.62A 209dC-1o7dC:
undetectable		 209dC-1o7dC:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		4 / 7 GLY B 390
PHE D 662
ARG D 815
GLU D 769
 None
 1.08A 2c8aB-1o7dB:
undetectable		 2c8aB-1o7dB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 VAL D 686
VAL D 689
ASP C 556
 None
 0.73A 2fumD-1o7dD:
0.7		 2fumD-1o7dD:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 MET A 211
THR E 955
LEU E1001
TRP E 908
LEU E 903
 None
 1.12A 2jfaA-1o7dA:
undetectable		 2jfaA-1o7dA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 TYR A 165
ARG D 750
ILE E 997
LEU E 942
VAL E 935
 None
 1.33A 2nyrB-1o7dA:
undetectable		 2nyrB-1o7dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 TYR A 165
ILE E 997
GLY C 519
LEU E 939
VAL E 935
 None
 1.45A 2nyrB-1o7dA:
undetectable		 2nyrB-1o7dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 LEU C 480
LEU C 486
GLY C 485
ALA B 419
LEU B 418
 None
 1.16A 2oz7A-1o7dC:
undetectable		 2oz7A-1o7dC:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 10 LEU E 992
LEU E 937
LEU E 896
LEU E 917
ARG E 901
 None
 1.17A 2riwA-1o7dE:
undetectable
2riwB-1o7dE:
0.0		 2riwA-1o7dE:
16.98
2riwB-1o7dE:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFU_A_MTLA1419_0
(XYLITOL OXIDASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		5 / 12 SER C 555
HIS D 690
VAL D 681
GLN C 558
LYS C 532
 None
 1.29A 2vfuA-1o7dC:
0.1		 2vfuA-1o7dC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 ARG A 202
GLU E 996
SER A 201
 None
 0.89A 2xkkA-1o7dA:
undetectable
2xkkC-1o7dA:
undetectable		 2xkkA-1o7dA:
16.54
2xkkC-1o7dA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		4 / 7 GLU D 751
ARG D 857
GLU A 203
ARG A 202
 None
 1.16A 2zt7A-1o7dD:
0.9		 2zt7A-1o7dD:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		3 / 3 ASN A 158
HIS C 445
VAL A  75
 None
 0.77A 3elzB-1o7dA:
0.0		 3elzB-1o7dA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 MET A 211
LEU E 956
THR E 955
LEU E 914
LEU E 903
 None
 0.72A 3hm1A-1o7dA:
undetectable		 3hm1A-1o7dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		5 / 12 GLY D 800
SER B 393
ASP D 746
ILE D 782
LEU D 811
 None
 1.15A 3iv6D-1o7dD:
undetectable		 3iv6D-1o7dD:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		5 / 12 ILE A 121
GLY A 153
ALA E 957
PHE A 178
ALA A 151
 None
 1.08A 3jb1A-1o7dA:
0.0		 3jb1A-1o7dA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 7 HIS C 446
GLN A  93
PHE A 320
VAL A  97
 ZN  A   3 ( 3.4A)
None
None
None
 0.98A 3jwqC-1o7dC:
undetectable		 3jwqC-1o7dC:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		3 / 3 ASN D 748
ASP A 159
ARG A 229
 None
 0.84A 3k13C-1o7dD:
undetectable		 3k13C-1o7dD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 8 TYR D 775
ALA A 161
THR D 795
LEU D 811
 None
 0.97A 3l4dA-1o7dD:
undetectable		 3l4dA-1o7dD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 LEU C 465
HIS C 445
GLY C 451
THR C 452
SER C 453
 None
 1.36A 3okxA-1o7dC:
0.0		 3okxA-1o7dC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		4 / 6 ASN B 407
TYR B 406
TYR A 165
GLU E 918
 None
 1.07A 3q5sA-1o7dB:
undetectable		 3q5sA-1o7dB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 ILE D 782
LEU D 804
VAL D 771
ILE D 730
HIS D 842
 None
 1.14A 3sp9A-1o7dD:
undetectable		 3sp9A-1o7dD:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 TYR B 380
GLU D 769
TYR B 385
 None
 0.86A 3ug8A-1o7dB:
undetectable		 3ug8A-1o7dB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 PHE A 253
TYR A 307
TYR B 359
 None
 0.80A 4ffwA-1o7dA:
undetectable		 4ffwA-1o7dA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		3 / 3 GLU A 120
ASP A  73
ASP C 447
 None
None
TRS  A   2 (-3.6A)
 0.67A 4gc9A-1o7dA:
undetectable		 4gc9A-1o7dA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 8 ILE A 117
ILE A 195
PHE A 217
GLY A 215
 None
 0.83A 4hb6A-1o7dA:
undetectable		 4hb6A-1o7dA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 8 ILE A 117
ILE A 195
PHE A 217
GLY A 215
 None
 0.75A 4hb8A-1o7dA:
undetectable		 4hb8A-1o7dA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 8 ILE A 117
ILE A 195
PHE A 217
GLY A 215
 None
 0.83A 4hdlA-1o7dA:
0.0		 4hdlA-1o7dA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 5 LEU D 865
ARG E 901
ILE A 169
ASN A 158
 None
 1.34A 4i00A-1o7dD:
undetectable		 4i00A-1o7dD:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 11 GLY A 154
ALA A 167
PRO A 189
MET A 211
PHE A 213
 None
 1.47A 4j4vD-1o7dA:
undetectable
4j4vE-1o7dA:
0.0		 4j4vD-1o7dA:
20.63
4j4vE-1o7dA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 8 LEU E 939
LEU E 942
LEU E 892
ILE E 990
 None
 0.81A 4klaA-1o7dE:
undetectable		 4klaA-1o7dE:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		4 / 6 GLU D 751
ARG D 857
GLU A 203
SER D 747
 None
 1.41A 4kr3A-1o7dD:
undetectable		 4kr3A-1o7dD:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 6 LEU C 436
ASN C 437
LEU C 443
VAL A 156
 None
 0.97A 4okbA-1o7dC:
0.8		 4okbA-1o7dC:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 7 LEU E 956
LEU E 992
LEU E 903
ILE E 990
 None
 0.99A 4okwA-1o7dE:
undetectable		 4okwA-1o7dE:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		4 / 6 TYR D 775
GLY B 390
GLU D 728
ARG D 815
 None
 1.39A 4zbqA-1o7dD:
undetectable		 4zbqA-1o7dD:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 GLY A 317
LEU A 148
PHE A 183
PHE A 150
LEU A 101
 None
 1.17A 4ze1A-1o7dA:
0.0		 4ze1A-1o7dA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 LEU E 915
PHE E 943
GLY E 891
LEU E 896
THR E 989
 None
 1.15A 4ze2A-1o7dE:
undetectable		 4ze2A-1o7dE:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 4 VAL A  97
ALA A  95
ASN A  90
GLN A  93
 None
 1.38A 4zgfA-1o7dA:
0.0		 4zgfA-1o7dA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 LEU E 951
ALA E1002
LEU E 915
ILE E 990
ALA E 988
 None
 1.02A 5eypB-1o7dE:
undetectable		 5eypB-1o7dE:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 6 ILE D 730
TYR D 642
PHE D 641
THR D 735
 None
 1.28A 5g08A-1o7dD:
undetectable		 5g08A-1o7dD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 VAL D 672
HIS D 814
VAL D 813
 None
 0.67A 5jmnC-1o7dD:
0.0		 5jmnC-1o7dD:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 VAL A 293
LYS B 347
MET A  62
 None
 0.58A 5nknA-1o7dA:
undetectable		 5nknA-1o7dA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 LEU E 951
LEU E1001
TRP E 908
 None
 0.80A 5nwuA-1o7dE:
undetectable		 5nwuA-1o7dE:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 5 ARG D 805
LEU D 804
ASN D 667
VAL D 771
 None
 1.29A 5os7B-1o7dD:
undetectable		 5os7B-1o7dD:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		5 / 12 ALA E 957
ARG A 177
GLY A 175
GLY A 154
GLU A 149
 None
 1.07A 5ul4A-1o7dE:
undetectable		 5ul4A-1o7dE:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		5 / 12 LEU A 297
ALA A 300
PRO A 264
GLY A 266
LEU A 267
 None
 1.03A 6b0iB-1o7dA:
undetectable		 6b0iB-1o7dA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		4 / 5 THR C 452
HIS C 445
ASP A  74
HIS C 446
 None
None
ZN  A   3 ( 2.3A)
ZN  A   3 ( 3.4A)
 1.44A 6dchA-1o7dC:
undetectable		 6dchA-1o7dC:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus;
Bos
taurus) 		4 / 5 THR A 173
ARG E 916
THR A 163
GLN C 444
 None
 1.50A 6ectA-1o7dA:
0.4		 6ectA-1o7dA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		3 / 3 HIS A 311
ASN A  64
LEU A  63
 None
 0.86A 6f7lB-1o7dA:
undetectable		 6f7lB-1o7dA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus) 		4 / 5 ARG D 805
LEU D 804
ASN D 667
VAL D 771
 None
 1.29A 6gmdA-1o7dD:
undetectable		 6gmdA-1o7dD:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE
(Bos
taurus;
Bos
taurus) 		5 / 12 ARG A 126
PHE A 123
TYR C 461
TYR A  89
ILE A  88
 None
 1.20A 6mkeB-1o7dA:
undetectable
6mkeC-1o7dA:
undetectable		 6mkeB-1o7dA:
13.45
6mkeC-1o7dA:
13.45