SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		5 / 9 THR A 111
LEU A 107
ALA A 159
TYR A 162
LEU A 158
 None
 1.37A 2azqA-1o7fA:
undetectable		 2azqA-1o7fA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		3 / 3 LYS A 287
ASP A 274
CYH A 218
 None
 1.29A 2br4F-1o7fA:
undetectable		 2br4F-1o7fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 6 LEU A 428
LEU A 339
GLU A 332
MET A 310
 None
 1.11A 2kuhA-1o7fA:
1.2		 2kuhA-1o7fA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		3 / 3 ARG A 215
GLU A 277
GLN A 216
 None
 1.00A 2p16A-1o7fA:
undetectable		 2p16A-1o7fA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		5 / 10 ILE A 104
PHE A  71
LEU A  64
ILE A 388
GLY A 114
 None
 1.22A 2v0mA-1o7fA:
undetectable		 2v0mA-1o7fA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		5 / 12 ALA A  85
LEU A 135
ARG A 137
ILE A  68
LEU A  88
 None
 1.15A 3k2hA-1o7fA:
undetectable		 3k2hA-1o7fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 8 VAL A 384
ARG A 421
LEU A 107
ILE A 379
 None
 0.92A 5v0vA-1o7fA:
2.3		 5v0vA-1o7fA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 6 HIS A 359
ARG A 429
GLU A 357
TYR A 377
 None
 1.43A 5x7pA-1o7fA:
undetectable		 5x7pA-1o7fA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 6 HIS A 359
ARG A 429
GLU A 357
TYR A 377
 None
 1.44A 5x7qA-1o7fA:
2.3		 5x7qA-1o7fA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 6 HIS A 359
ARG A 429
GLU A 357
TYR A 377
 None
 1.50A 5x7qB-1o7fA:
2.7		 5x7qB-1o7fA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 6 HIS A 359
ARG A 429
GLU A 357
TYR A 377
 None
 1.41A 5x7rA-1o7fA:
0.0		 5x7rA-1o7fA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR
(Mus
musculus) 		4 / 6 HIS A 359
ARG A 429
GLU A 357
TYR A 377
 None
 1.45A 5x7rB-1o7fA:
2.7		 5x7rB-1o7fA:
16.16