SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1o7l TRANSCRIPTIONAL
REGULATOR MODE
(Escherichia
coli) 		3 / 3 ASP A 200
ASN A 201
THR A 248
 None
 0.80A 2q63B-1o7lA:
undetectable		 2q63B-1o7lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1o7l TRANSCRIPTIONAL
REGULATOR MODE
(Escherichia
coli) 		4 / 5 ARG A  21
ALA A  51
ASP A  50
GLU A  54
 None
 1.33A 2xrzA-1o7lA:
undetectable		 2xrzA-1o7lA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1o7l TRANSCRIPTIONAL
REGULATOR MODE
(Escherichia
coli) 		4 / 5 LEU A 181
GLN A 124
THR A 125
THR A 260
 None
 1.30A 2zj0B-1o7lA:
undetectable		 2zj0B-1o7lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1o7l TRANSCRIPTIONAL
REGULATOR MODE
(Escherichia
coli) 		5 / 10 ILE A 180
THR A 260
ILE A 135
VAL A 147
VAL A 149
 None
 1.09A 3me6A-1o7lA:
undetectable		 3me6A-1o7lA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1o7l TRANSCRIPTIONAL
REGULATOR MODE
(Escherichia
coli) 		5 / 10 VAL A 256
ILE A 180
ILE A 135
VAL A 147
VAL A 149
 None
 1.03A 3me6A-1o7lA:
undetectable		 3me6A-1o7lA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1o7l TRANSCRIPTIONAL
REGULATOR MODE
(Escherichia
coli) 		4 / 7 LEU A 203
LEU A 158
ASN A 252
ASP A 200
 None
 0.82A 4rmjA-1o7lA:
undetectable		 4rmjA-1o7lA:
22.84