SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 GLY A 160
THR A 162
ALA A 294
GLY A 125
ALA A 295
 None
 0.98A 1gtnL-1o8cA:
undetectable
1gtnV-1o8cA:
undetectable		 1gtnL-1o8cA:
13.12
1gtnV-1o8cA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1o8c YHDH
(Escherichia
coli) 		4 / 5 ASP A  43
LEU A   6
ALA A 307
LEU A  39
 None
 1.13A 1nh8A-1o8cA:
0.0		 1nh8A-1o8cA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1o8c YHDH
(Escherichia
coli) 		5 / 10 LEU A  98
ALA A   3
LEU A   5
MET A  59
LEU A   6
 None
 1.42A 1pcgB-1o8cA:
undetectable		 1pcgB-1o8cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1o8c YHDH
(Escherichia
coli) 		5 / 10 LEU A  98
ALA A   3
LEU A   5
MET A  59
LEU A   6
 None
 1.40A 1qktA-1o8cA:
undetectable		 1qktA-1o8cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1o8c YHDH
(Escherichia
coli) 		5 / 11 GLY A 125
ALA A 295
GLY A 160
THR A 162
ALA A 294
 None
 1.04A 1utdP-1o8cA:
undetectable
1utdQ-1o8cA:
undetectable		 1utdP-1o8cA:
13.12
1utdQ-1o8cA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1o8c YHDH
(Escherichia
coli) 		4 / 8 THR A 319
GLY A 125
THR A 126
ALA A 127
 None
None
NDP  A1325 (-4.4A)
NDP  A1325 ( 4.0A)
 0.76A 2a1hA-1o8cA:
undetectable
2a1hB-1o8cA:
undetectable		 2a1hA-1o8cA:
25.00
2a1hB-1o8cA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1o8c YHDH
(Escherichia
coli) 		4 / 8 VAL A 152
ARG A 318
GLY A 317
ALA A 294
 None
 0.94A 2xfsA-1o8cA:
0.0		 2xfsA-1o8cA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1o8c YHDH
(Escherichia
coli) 		4 / 8 VAL A 152
ARG A 318
GLY A 317
ALA A 294
 None
 0.93A 2xh9A-1o8cA:
0.0		 2xh9A-1o8cA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1o8c YHDH
(Escherichia
coli) 		5 / 9 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
 None
NDP  A1325 (-3.4A)
NDP  A1325 (-3.1A)
None
None
 0.93A 2z0yA-1o8cA:
2.1		 2z0yA-1o8cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1o8c YHDH
(Escherichia
coli) 		5 / 9 VAL A 164
GLY A 158
GLY A 157
LEU A 166
ALA A 131
 None
NDP  A1325 (-3.4A)
NDP  A1325 (-3.1A)
None
None
 0.95A 2z0yB-1o8cA:
2.3		 2z0yB-1o8cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1o8c YHDH
(Escherichia
coli) 		4 / 7 GLY A  62
ALA A 102
ALA A  99
VAL A 104
 None
 0.73A 3a2qA-1o8cA:
undetectable		 3a2qA-1o8cA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1o8c YHDH
(Escherichia
coli) 		3 / 3 GLY A  97
GLY A  91
GLY A  62
 None
 0.40A 3bogC-1o8cA:
undetectable		 3bogC-1o8cA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1o8c YHDH
(Escherichia
coli) 		5 / 11 LEU A   4
ILE A  60
PRO A  61
GLY A  97
SER A  37
 None
 1.42A 3bpxA-1o8cA:
undetectable
3bpxB-1o8cA:
0.0		 3bpxA-1o8cA:
17.35
3bpxB-1o8cA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 1o8c YHDH
(Escherichia
coli) 		4 / 4 ARG A  76
ASP A  29
ASP A  74
PRO A  75
 None
 1.40A 3fgrB-1o8cA:
0.0		 3fgrB-1o8cA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 1o8c YHDH
(Escherichia
coli) 		5 / 9 ILE A  47
ALA A   3
LEU A   4
LEU A  39
ALA A  44
 None
 1.02A 3ozvB-1o8cA:
4.0		 3ozvB-1o8cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1o8c YHDH
(Escherichia
coli) 		5 / 10 ALA A 127
LEU A  39
ILE A 310
ALA A 307
THR A  48
 NDP  A1325 ( 4.0A)
None
NDP  A1325 (-4.3A)
None
None
 1.43A 3r9cA-1o8cA:
undetectable		 3r9cA-1o8cA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1o8c YHDH
(Escherichia
coli) 		3 / 3 ASN A  40
ALA A 127
ARG A 318
 None
NDP  A1325 ( 4.0A)
None
 0.84A 3tj7C-1o8cA:
undetectable
3tj7D-1o8cA:
1.0		 3tj7C-1o8cA:
20.06
3tj7D-1o8cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 10 ALA A 141
ARG A 261
GLY A 235
LEU A 138
ILE A 150
 None
 1.17A 3wdmB-1o8cA:
2.2		 3wdmB-1o8cA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 10 ALA A 141
ARG A 261
GLY A 235
LEU A 138
ILE A 150
 None
 1.13A 3wdmD-1o8cA:
2.2		 3wdmD-1o8cA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 LEU A  14
ALA A  15
LEU A  98
ILE A  60
GLY A  62
 None
 1.09A 4dm8B-1o8cA:
undetectable		 4dm8B-1o8cA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 VAL A  34
ALA A  99
LEU A  25
PHE A  65
LEU A 109
 None
 1.19A 4eckB-1o8cA:
undetectable		 4eckB-1o8cA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 VAL A  34
ALA A  99
PHE A  65
LEU A 109
VAL A  32
 None
 1.06A 4eckB-1o8cA:
undetectable		 4eckB-1o8cA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 LEU A  98
GLY A  96
MET A  59
LEU A   6
THR A 126
 None
None
None
None
NDP  A1325 (-4.4A)
 1.47A 4p6xE-1o8cA:
0.0		 4p6xE-1o8cA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 ALA A 176
VAL A 152
LEU A 282
ALA A 165
LEU A 170
 None
 1.13A 4qrcA-1o8cA:
undetectable		 4qrcA-1o8cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1o8c YHDH
(Escherichia
coli) 		3 / 3 GLU A 302
ALA A 303
PHE A 306
 None
 0.61A 4v1fA-1o8cA:
undetectable		 4v1fA-1o8cA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1o8c YHDH
(Escherichia
coli) 		3 / 3 GLU A 302
ALA A 303
PHE A 306
 None
 0.63A 4v1fC-1o8cA:
undetectable		 4v1fC-1o8cA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1o8c YHDH
(Escherichia
coli) 		4 / 7 VAL A  17
GLN A   2
LEU A 300
SER A 299
 None
 1.10A 4zphA-1o8cA:
0.0
4zphB-1o8cA:
0.0		 4zphA-1o8cA:
21.65
4zphB-1o8cA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 1o8c YHDH
(Escherichia
coli) 		5 / 10 LEU A  98
ALA A   3
LEU A   5
MET A  59
LEU A   6
 None
 1.44A 5dxeB-1o8cA:
undetectable		 5dxeB-1o8cA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
 None
NDP  A1325 (-3.5A)
NDP  A1325 (-4.0A)
None
None
 1.05A 5jw1A-1o8cA:
undetectable		 5jw1A-1o8cA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
 None
NDP  A1325 (-3.5A)
NDP  A1325 (-4.0A)
None
None
 1.06A 5kirA-1o8cA:
undetectable		 5kirA-1o8cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 VAL A 265
ALA A 243
VAL A 159
GLY A 128
ALA A 131
 None
NDP  A1325 (-3.5A)
NDP  A1325 (-4.0A)
None
None
 1.05A 5kirB-1o8cA:
undetectable		 5kirB-1o8cA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 12 LEU A  98
GLY A  96
ILE A  47
GLY A  91
GLY A  62
 None
 1.00A 5wyqA-1o8cA:
undetectable		 5wyqA-1o8cA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1o8c YHDH
(Escherichia
coli) 		4 / 5 GLY A 220
ASP A 221
ARG A 198
GLN A 230
 None
None
NDP  A1325 (-3.6A)
None
 1.25A 5zrfB-1o8cA:
undetectable		 5zrfB-1o8cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 9 GLY A 157
ILE A 298
LEU A 320
LYS A 296
ASP A  43
 NDP  A1325 (-3.1A)
None
None
None
None
 1.47A 6c2mC-1o8cA:
undetectable		 6c2mC-1o8cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1o8c YHDH
(Escherichia
coli) 		5 / 9 GLY A 157
ILE A 298
LEU A 320
LYS A 296
ASP A  64
 NDP  A1325 (-3.1A)
None
None
None
None
 1.31A 6c2mC-1o8cA:
undetectable		 6c2mC-1o8cA:
15.05