SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1o8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		5 / 12 GLY A  60
VAL A 139
ILE A  89
VAL A 132
ILE A  57
 None
 0.99A 2avsB-1o8pA:
undetectable		 2avsB-1o8pA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 6 SER A  24
ASP A  69
SER A  27
VAL A 145
 None
 1.17A 2hdnI-1o8pA:
undetectable
2hdnJ-1o8pA:
undetectable
2hdnL-1o8pA:
undetectable		 2hdnI-1o8pA:
17.36
2hdnJ-1o8pA:
19.94
2hdnL-1o8pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 6 SER A  27
VAL A 145
SER A  24
ASP A  69
 None
 1.30A 2hdnJ-1o8pA:
undetectable
2hdnK-1o8pA:
undetectable
2hdnL-1o8pA:
undetectable		 2hdnJ-1o8pA:
19.94
2hdnK-1o8pA:
17.36
2hdnL-1o8pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 5 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.15A 4w5oA-1o8pA:
undetectable		 4w5oA-1o8pA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		3 / 3 ARG A  80
ASP A 142
TRP A 143
 None
CA  A1149 (-3.4A)
None
 0.28A 4xdqA-1o8pA:
4.7		 4xdqA-1o8pA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 5 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.10A 4z4cA-1o8pA:
undetectable		 4z4cA-1o8pA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 5 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.12A 4z4dA-1o8pA:
undetectable		 4z4dA-1o8pA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 5 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.12A 4z4eA-1o8pA:
undetectable		 4z4eA-1o8pA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1o8p PUTATUVE
ENDO-XYLANASE
([Clostridium]
stercorarium) 		4 / 6 PHE A 135
PRO A 138
VAL A 139
PHE A 112
 None
 1.11A 5t7bA-1o8pA:
undetectable		 5t7bA-1o8pA:
10.89